Study of DE-108 Ophthalmic Solution in Patients Who Are Scheduled for Cataract Surgery

NCT ID: NCT02573610

Last Updated: 2017-10-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

576 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-21

Study Completion Date

2017-03-31

Brief Summary

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The purpose of this study is to evaluate superior efficacy of DE-108 ophthalmic solution to that of Levofloxacin 0.5% ophthalmic solution as well as safety of the former used for perioperative bacteria eradication in patients who are scheduled for cataract surgery.

Detailed Description

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Conditions

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Cataract Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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DE-108

High concentration / Antibacterial Ophthalmic Solution

Group Type EXPERIMENTAL

DE-108

Intervention Type DRUG

Subjects will be assigned to receive DE-108 ophthalmic solution to be administrated one drop a time 3 times daily for 3 days prior and for 14 days following cataract surgery.

Levofloxacin 0.5%

Low concentration / Antibacterial Ophthalmic Solution

Group Type ACTIVE_COMPARATOR

Levofloxacin 0.5%

Intervention Type DRUG

Subjects will be assigned to receive Levofloxacin 0.5% ophthalmic solution to be administrated one drop a time 3 times daily for 3 days prior and for 14 days following cataract surgery.

Interventions

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DE-108

Subjects will be assigned to receive DE-108 ophthalmic solution to be administrated one drop a time 3 times daily for 3 days prior and for 14 days following cataract surgery.

Intervention Type DRUG

Levofloxacin 0.5%

Subjects will be assigned to receive Levofloxacin 0.5% ophthalmic solution to be administrated one drop a time 3 times daily for 3 days prior and for 14 days following cataract surgery.

Intervention Type DRUG

Other Intervention Names

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Levofloxacin

Eligibility Criteria

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Inclusion Criteria

* Those who are scheduled for cataract surgery

Exclusion Criteria

* Those who with suspected ocular infections based on clinical findings in the study eye.
* Those who have any eye disease other than cataract which requires treatment in the target eye.
* Those who have a history of allergy to the drugs to be used during the clinical study (such as fluoroquinolones, topical anesthetics and povidon iodine)
* Those who need to wear contact lenses during the study period
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Santen Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kyungpook National University Hospital

Kyungpook, , South Korea

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

Kim's eye Hospital

Seoul, , South Korea

Site Status

Seoul National University Bundang Hospital

Seoul, , South Korea

Site Status

Seoul Saint Marry's Hospital

Seoul, , South Korea

Site Status

Severance Hospital, Yonsei University Health System

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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DE-108

Identifier Type: -

Identifier Source: org_study_id