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Effect of Acute Physical Exercise on Memory

NCT ID: NCT04680494

Last Updated: 2020-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-09

Study Completion Date

2016-07-27

Brief Summary

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An increasing amount of studies show the beneficial effect of regular exercise on cognitive and brain functions and especially in the memory domain. Yet little is known of what happens within an acute bout of exercise and whether it would also yield cognitive effects. The literature clearly shows that molecules such as brain derived neurotrophic factor (BDNF) and endocannabinoids (mainly anandamide, AEA) are heavily involved in neural plasticity mechanisms and increase when we exercise hinting at possible mechanisms underlying memory improvement after exercise.

This protocol assesses the effects of acute exercise on associative and motor sequence memory, their underlying neural activations (measured using fMRI) and blood biomarkers (BDNF and AEA). A related aim is to assess the effect of exercise intensity, therefore three exercising conditions (rest, moderate intensity and high intensity) were included. Finally, a 3-month delayed retest visit is also realized to assess effects of acute exercise on long-term memory consolidation.

Detailed Description

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Conditions

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Acute Physical Exercise

Keywords

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fMRI BDNF endocannabinoid physical exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This is a within-subject study, all participants perform all conditions in cross-over randomized order.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Rest

Participants rest quietly for 30 minutes, sitting on a chair. They may read magazines not involving motion-related elements

Group Type EXPERIMENTAL

rest

Intervention Type OTHER

Moderate intensity exercise

Participants cycle on a cycle ergometer during 30 minutes at 65% of their maximal cardiac frequency

Group Type EXPERIMENTAL

moderate intensity physical exercise

Intervention Type OTHER

High intensity exercise

Participants cycle on a cycle ergometer during 15 minutes at 75% of their maximal cardiac frequency. This session also includes 3 minutes of warm-up and three minutes of cool down at 50% of their maximal cardiac frequency

Group Type EXPERIMENTAL

high intensity physical exercise

Intervention Type OTHER

Interventions

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moderate intensity physical exercise

Intervention Type OTHER

high intensity physical exercise

Intervention Type OTHER

rest

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male
* Right-handed,
* Exercising regularly (at least twice per week).
* VO2max comprised between 40ml/kg/min and 65ml/kg/min.

Exclusion Criteria

\- Psychiatric and neurological history
Minimum Eligible Age

18 Years

Maximum Eligible Age

38 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Geneva

OTHER

Sponsor Role collaborator

University of Geneva, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Igloi Kinga

Senior lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Marin Bosch B, Bringard A, Logrieco MG, Lauer E, Imobersteg N, Thomas A, Ferretti G, Schwartz S, Igloi K. Effect of acute physical exercise on motor sequence memory. Sci Rep. 2020 Sep 18;10(1):15322. doi: 10.1038/s41598-020-72108-1.

Reference Type RESULT
PMID: 32948800 (View on PubMed)

Other Identifiers

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PB_2017-00360

Identifier Type: -

Identifier Source: org_study_id