Anatomical Resection of Liver MetAstases iN patIents With RAS-mutated Colorectal Cancer
NCT ID: NCT04678583
Last Updated: 2024-06-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
240 participants
INTERVENTIONAL
2021-01-01
2027-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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A - Anatomical resection
removal of the entire, tumor-bearing liver segment(s)
Resection of colorectal liver metastases
Comparison of two liver surgery methods
B - Non-anatomical resection
metastasectomy with a margin of healthy liver tissue irrespective of segmental borders
Resection of colorectal liver metastases
Comparison of two liver surgery methods
Interventions
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Resection of colorectal liver metastases
Comparison of two liver surgery methods
Eligibility Criteria
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Inclusion Criteria
* Colorectal liver metastases (single or multiple)
* Planned R0 resection of liver metastases (and primary tumor, if present)
* Anatomical and non-anatomical liver resection technically feasible
* Male and female patients, age ≥ 18 years
* Written informed consent
Exclusion Criteria
* Planned staged liver resection (e.g. two-stage hepatectomy)
* Diagnosis of another cancer \< 5 years prior to randomization Exceptions: curatively treated in situ cervical cancer, curatively resected non-melanoma skin cancer
* Expected lack of compliance
* Addiction or other illnesses which do not allow the person concerned to assess the nature and extent of the clinical trial and its possible consequences
18 Years
ALL
No
Sponsors
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German Cancer Research Center
OTHER
Technische Universität Dresden
OTHER
Responsible Party
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Principal Investigators
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Jürgen Weitz, Prof Dr med
Role: PRINCIPAL_INVESTIGATOR
Department of Gastrointestinal-, Thoracic and Vascular Surgery, University Hospital CGC
Nuh Rahbari, Prof Dr med
Role: PRINCIPAL_INVESTIGATOR
Allgemein- und Viszeralchirugie, University Hospital Ulm
Locations
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Department of Surgery at the University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University
Mannheim, Baden-Wurttemberg, Germany
Department of Gastrointestinal-, Thoracic and Vascular Surgery University Hospital Carl Gustav Carus Technische Universität Dresden
Dresden, Saxony, Germany
Intestinal Center West Middle Franconia, ANregiomed Clinic Ansbach
Ansbach, , Germany
Clinic for General, Vizeral and Transplant Surgery, Augsburg University Hospital
Augsburg, , Germany
Department of General, Visceral and Vascular Surgery, Charité, University Medicine Berlin, Campus Benjamin Franklin Berlin
Berlin, , Germany
Clinic and Polyclinic for General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn
Bonn, , Germany
Surgical Clinic, Municipal Hospital Braunschweig gGmbH
Braunschweig, , Germany
Cancer Center, Helios Amper-Hospital Dachau
Dachau, , Germany
Surgical Clinic, Dortmund Hospital
Dortmund, , Germany
Clinic for General and Visceral Surgery, Municipal Hospital Dresden
Dresden, , Germany
Clinic for General, Visceral and Pediatric Surgery, University Hospital Düsseldorf
Düsseldorf, , Germany
Surgical Clinic, University Hospital Erlangen
Erlangen, , Germany
Clinic for General, Visceral and Transplant Surgery, University Hospital Frankfurt, Goethe University Frankfurt am Main
Frankfurt, , Germany
Department for General and Visceral Surgery, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg
Freiburg im Breisgau, , Germany
JLU Gießen, Department for General, Visceral, Thoracic and Transplant Surgery
Giessen, , Germany
Clinic for General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Georg-August-University
Göttingen, , Germany
Clinic and Polyclinic for General Surgery, Department of Gastrointestinal, Thoracic and Vascular Surgery, University Greifswald, University Hospital Greifswald
Greifswald, , Germany
University Hospital and Polyclinic for Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale)
Halle, , Germany
Center for Surgical Medicine - Clinic and Polyclinic for General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf
Hamburg, , Germany
Department of Liver, Bile Duct and Pancreas Surgery, University Department of surgery, Asklepios Klinik Barmbek
Hamburg, , Germany
Clinic for General, Visceral and Minimally Invasive Surgery, KRH Clinic Siloah, Hannover
Hanover, , Germany
Medizinische Hochschule Hannover, Department of General, Visceral and Transplant Surgery
Hanover, , Germany
Department of General, Visceral and Transplantation Surgery, University of Heidelberg
Heidelberg, , Germany
General Visceral and Vascular Surgery, Jena University Medical Center
Jena, , Germany
Clinic for Surgery, University Hospital Schleswig-Holstein Lübeck Campus
Lübeck, , Germany
University Department of General, Visceral, Vascular and Transplant Surgery, Faculty of Medicine, Otto von Guericke University Magdeburg
Magdeburg, , Germany
Clinic for General, Visceral and Transplantation Surgery, University Medical Center of the Johannes Gutenberg-University Mainz
Mainz, , Germany
Clinic for Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg
Marburg, , Germany
LMU Munich Hospital, Clinic for General, Visceral and Transplant Surgery
Munich, , Germany
Department Hepato-Pancreato-Biliary Surgery, Barmherzige Brüder gGmbH of the Hospital Barmherzige Brüder Munich
München, , Germany
Department of Surgery, University Hospital rechts der Isar
München, , Germany
Clinic for General, Visceral and Transplant Surgery, University of Münster
Münster, , Germany
University Hospital for General and Visceral Surgery, Oldenburg Hospital
Oldenburg, , Germany
Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center
Tübingen, , Germany
Clinic for General and Visceral Surgery, Ulm University Medical Center
Ulm, , Germany
General and Visceral Surgery, Helios University Medical Center Wuppertal, University Witten/Herdecke
Wuppertal, , Germany
Department for General, Visceral, Transplant, Vascular and Pediatric Surgery, Julius-Maximilian-University Würzburg, University Hospital Würzburg
Würzburg, , Germany
Countries
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Central Contacts
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Facility Contacts
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Jürgen Weitz, Prof Dr med
Role: primary
Secretary
Role: backup
Other Identifiers
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VTG-08
Identifier Type: -
Identifier Source: org_study_id
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