An Open Label Study of the Effects of SHR1459 in NMOSDs Patients

NCT ID: NCT04670770

Last Updated: 2023-03-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-01-20
• Study Completion Date: 2022-08-15

Brief Summary

This is an open-label study, to evaluate the efficacy and safety of SHR1459 in participants with NMOSDs.

Detailed Description

Therefore, the investigators of this study are investigating whether SHR1459 could prevent relapse of NMOSDs.

The primary objective of this study is to evaluate the effectiveness of SHR1459 in NMOSDs patients.

The secondary objectives are to determine:

The safety profile of SHR 1459 in patients with NMOSDs. Whether SHR1459 reduce MRI lesions and APQ4-Abs level.

Conditions

Neuromyelitis Optica Spectrum Disorders

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

SHR1459

SHR1459

Group Type: EXPERIMENTAL

Drug - SHR1459

Intervention Type: DRUG

Oral Tablets taken once daily for 52 weeks

Interventions

Drug - SHR1459

Oral Tablets taken once daily for 52 weeks

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. 18-75 years of age.

2. Diagnosis of AQP4-IgG positive NMOSD according to IPND diagnostic criteria 2015 at screening.

3. Having a documented history of 2 or more NMOSD relapse required rescue therapy(ies) within the last 12 months.

4. Subjects must be stable treatment (if any) for more than 1 month before starting the IP treatment, which is defined as follows:- Expanded disability status scale (EDSS) score≦7.5

5. Written informed consent obtained before any study procedure.

6. Subjects are willing and able to comply with the visit schedule and treatment plan, laboratory tests and other study procedures.

Exclusion Criteria

1. Allergic to the investigative product or any ingredient in the investigative product.

2. Past or current malignancy, except for cutaneous non-metastatic basal cell carcinoma or squamous cell carcinoma that has been adequately treated or removed

3. The subject currently has a central nervous system (CNS) disease that may affect the assessment of NMOSD;

4. Severe and uncontrolled conditions that the investigator determines may affect subjects' safety, trial compliance, evaluation of the end point, or the need to use medications not permitted in the protocol;

5. The investigator judges that the subject has a disease that affects the absorption, distribution, metabolism and excretion of the drug;

6. The subjects had any major clinical infection and was hospitalized or treated with parenteral antibiotics within 1 month before screening; Or other infections that investigator thought might aggravate as a result of participating in the study;

7. The subject may have an active, latent or undertreated Mycobacterium tuberculosis (ie, tuberculosis [TB]) infection, defined as follows:

• The result of QuantiFERON-TB Gold (QFT Gold test) was positive or the result of T-SPOT.TB was positive within 3 months before screening/screening period.
• Or chest imaging examinations suggest the presence of active tuberculosis infection within 3 months before screening / during the screening period;
• The result of QuantiFERON-TB Gold (QFT Gold test) was positive or the result of T-SPOT.TB was positive within 3 months before screening/screening period.
• Or chest imaging examinations suggest the presence of active tuberculosis infection within 3 months before screening / during the screening period;

8. Positive laboratory tests related to human immunodeficiency virus (HIV) or hepatitis B virus or hepatitis C virus;

9. Have received BTK inhibitors (e.g. ibrutinib) at any time in the past.

10. Received B-cell targeted therapy (such as rituximab) within 12 weeks before the first administration.

11. Received biological agents such as eculizumab, tocilizumab, Satralizumab, Alemtuzumab, Natalizumab within 12 weeks before the first administration;

12. Subjects who may receive any live attenuated vaccine during the screening period or have received any live virus vaccine within 8 weeks prior to initial administration;

13. Any concomitant disease other than NMOSD that requires glucocorticoid therapy (oral or IV) within the 6 months prior to screening.

14. Abnormal and clinically significant ECG examination during screening.

15. Alanine glutamate aminotransferase (ALT)>2 times the upper limit of normal (ULN) and/or glutamate aspartate aminotransferase (AST)>2 times ULN and/or bilirubin>2 times ULN during the screening period ULN;

16. Abnormal white blood cell count, neutrophil count, lymphocyte count, or platelet count during the screening period are considered unsuitable for participating in the study after the investigator's assessment (refer to the following criteria):

• Hemoglobin <100 g/L or hematocrit <30%;
• White blood cell (WBC) count<3.0×109/L (<3000/mm3) or ANC<1.2×109/L (<1200/mm3);
• Lymphocytes <0.8×109/L (<800/mm3);
• Platelet count<100×109/L (<100,000/mm3)

17. eGFR≤60 ml/min (calculated according to Cockcroft-Gault) or receiving dialysis during the screening period.

18. Unable to undergo MRI scans. History of clinically significant CNS trauma (e.g. traumatic brain injury, cerebral contusion, spinal cord compression)

19. Pregnant or breastfeeding women;

20. Use of an investigational drug or other experimental therapy within 4 weeks, 5 pharmacokinetic half-lives, or the duration of biological effect (whichever is longer) prior to screening.

21. Any other conditions in which the investigator or sponsor believes that the subject is not suitable for inclusion in the study.

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• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Reistone Biopharma Company Limited

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Xiangya Hospital Of Central South University

Changsha, , China

West China Hospital Sichuan University

Chengdu, , China

Lanzhou University Second Hospital

Lanzhou, , China

People's Hospital of Rizhao

Rizhao, , China

Huashan Hospital Affiliated To Fudan University

Shanghai, , China

First Hospital Of Shanxi Medical University

Taiyuan, , China

Tangdu Hosiptal

Xi'an, , China

The First Affiliated Hospital Of Zhengzhou University

Zhengzhou, , China

Countries

China

Other Identifiers

RSB20621

Identifier Type: -

Identifier Source: org_study_id