The Role of Statins in the Prevention of Contrast-induced Acute Kidney Injury in Patients With Cardiovascular Diseases
NCT ID: NCT04666389
Last Updated: 2023-01-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
150 participants
INTERVENTIONAL
2020-10-15
2023-01-10
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Control group
No statins being used for prevention
Atorvastatin
To compare the preventive role of low- and high-dose statin regimens in the prevention on contrast-induced acute kidney injury in statin-naive patients with cardiovascular diseases undergoing computer tomography with intravenous contrast media administration
Low-dose statin therapy
Atorvastatin 40 mg
Atorvastatin
To compare the preventive role of low- and high-dose statin regimens in the prevention on contrast-induced acute kidney injury in statin-naive patients with cardiovascular diseases undergoing computer tomography with intravenous contrast media administration
High-dose statin therapy
Atorvastatin 80 mg
Atorvastatin
To compare the preventive role of low- and high-dose statin regimens in the prevention on contrast-induced acute kidney injury in statin-naive patients with cardiovascular diseases undergoing computer tomography with intravenous contrast media administration
Interventions
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Atorvastatin
To compare the preventive role of low- and high-dose statin regimens in the prevention on contrast-induced acute kidney injury in statin-naive patients with cardiovascular diseases undergoing computer tomography with intravenous contrast media administration
Eligibility Criteria
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Inclusion Criteria
* Indications for computer tomography with intravenous contrast media administration
* Cardiovascular diseases (arterial hypertension, arrhythmia etc)
Exclusion Criteria
* Statin therapy before inclusion in the study
* Acute coronary syndromes
* Contraindications for statins administration
* Patients with chronic kidney disease stages 4-5
* Contraindications for computer tomography with contrast media administration
* Nephrotoxic drugs use (NSAIDS, vancomycin etc)
18 Years
ALL
No
Sponsors
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I.M. Sechenov First Moscow State Medical University
OTHER
Responsible Party
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Olga Mironova
Associate Professor
Principal Investigators
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Olga Mironova, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Sechenov University
Locations
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Sechenov University
Moscow, , Russia
Countries
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References
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Vasin AA, Mironova OI, Fomin VV. [The atorvastatin effects on the prevention of contrast-induced acute kidney injury during computed tomography with contrast media]. Ter Arkh. 2022 Oct 24;94(9):1057-1061. doi: 10.26442/0403660.2022.09.201845. Russian.
Related Links
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Vasin AA, Mironova OIu, Fomin VV. The atorvastatin effects on the prevention of contrast-induced acute kidney injury during computed tomography with contrast media. Terapevticheskii Arkhiv (Ter. Arkh.). 2022;94(9):1057-1061.
Vasin A.A., Mironova O.I., Fomin V.V. Intravenous contrast induced acute kidney injury prevention with high doses of statins. Eurasian heart journal. 2022;(3):84-88. (In Russ.)
Vasin AA, Mironova OIu, Fomin VV. Contrast-induced acute kidney injury after computed tomography with contrast media in patients with cardiovascular diseases. Consilium Medicum. 2021;23(12):928-930.
Other Identifiers
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09/2020
Identifier Type: -
Identifier Source: org_study_id
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