Viral Shedding, Symptoms and Exposure of SARS-CoV-2 in Non-hospitalized Children With COVID-19
NCT ID: NCT04666207
Last Updated: 2021-09-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
24 participants
OBSERVATIONAL
2020-05-25
2020-12-30
Brief Summary
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We want to test the following hypothesis:
1. Shedding load and duration of SARS-CoV-2 in children are related to age, gender, clinical symptoms and exposure
2. Salvia samples have equal or higher sensibility than nasal swaps in children for detection of SARS-CoV-2
3. Parental home testing of saliva and feces is feasible in children
The study is a prospective cohort study of SARS-CoV-2 PCR-positive children from two test centers in the Capital Region of Denmark. Children aged 0-17 years with a PCR-positive SARS-CoV-2 test from a nasal or pharyngeal swab is included from May 2020 to January 2021 and followed-up for a period of 28 days with weekly sample collection and questionnaires.
Samples include a saliva sample, a nasal swap and a rectal swap for children under four years of age. A semiquantitative RT-PCR method, will identify positive and negative samples and provide a Ct value estimating viral load. Saliva and fecal samples will be analyzed from November 2020-February 2021.
Shedding duration will be related to medial history, clinical presentation, exposure, gender and age.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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PCR
RT-PCR for SARS-CoV-2
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
0 Years
17 Years
ALL
No
Sponsors
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Rigshospitalet, Denmark
OTHER
Responsible Party
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Allan Bybeck Nielsen
Dr.
Principal Investigators
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Ulrikka Nygaard, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Rigshospitalet, Denmark
Locations
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Copenhagen University Hospital Rigshospitalet
Copenhagen, , Denmark
Countries
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Other Identifiers
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H-20028631-1
Identifier Type: -
Identifier Source: org_study_id
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