A Study of FOY-305 in Patients With SARS-Cov-2 Infection (COVID-19)

NCT ID: NCT04657497

Last Updated: 2024-04-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

155 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-09

Study Completion Date

2021-04-09

Brief Summary

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To assess the efficacy and safety of FOY-305 in patients with SARS-CoV-2 infection (COVID-19) in a placebo-controlled, multicenter, double-blind, randomized, parallel-group comparative study.

Detailed Description

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Conditions

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SARS-CoV-2 Infection (COVID-19)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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FOY-305 group

Camostat Mesilate tablets 600 mg will be orally administered 4 times daily, before breakfast, before lunch, before evening meal, and at bedtime. The treatment period is up to 14 days.

Group Type EXPERIMENTAL

FOY-305

Intervention Type DRUG

Specified Dosage and Duration of Treatment

Placebo group

Placebo tablets will be orally administered 4 times daily, before breakfast, before lunch, before evening meal, and at bedtime. The treatment period is up to 14 days.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Specified Dosage and Duration of Treatment

Interventions

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FOY-305

Specified Dosage and Duration of Treatment

Intervention Type DRUG

Placebo

Specified Dosage and Duration of Treatment

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Inpatient or outpatient: Inpatient
2. Positive SARS-CoV-2 test by a method eligible for definitive diagnosis
3. Enrollment in this study within 5 days after onset of symptoms of SARS-CoV-2 infection (COVID-19) (for asymptomatic patients, enrollment in this study within 5 days after collection of the sample that tested positive)

Exclusion Criteria

1. Receiving oxygen therapy
2. Difficulty in swallowing oral medication
3. History of COVID-19
4. History of vaccination against COVID-19
5. Taking camostat mesilate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ono Pharmaceutical Co. Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Naoyuki Komura

Role: STUDY_DIRECTOR

Ono Pharmaceutical Co. Ltd

Locations

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Aichi Clinical Site 1

Tokoname, Aichi-ken, Japan

Site Status

Chiba Clinical Site 1

Narita, Chiba, Japan

Site Status

Fukuoka Clinical Site 1

Ōkawa, Fukuoka, Japan

Site Status

Ibaraki Clinical Site 1

Tsuchiura, Ibaraki, Japan

Site Status

Ishikawa Clinical Site 1

Kanazawa, Ishikawa-ken, Japan

Site Status

Kanagawa Clinical Site 3

Kawasaki, Kanagawa, Japan

Site Status

Kanagawa Clinical Site 1

Yokohama, Kanagawa, Japan

Site Status

Kanagawa Clinical Site 2

Yokosuka, Kanagawa, Japan

Site Status

Mie Clinical Site 1

Yokkaichi, Mie-ken, Japan

Site Status

Niigata Clinical Site 1

Nagaoka, Niigata, Japan

Site Status

Osaka Clinical Site 2

Daitō, Osaka, Japan

Site Status

Saitama Clinical Site 3

Kawagoe, Saitama, Japan

Site Status

Saitama Clinical Site 1

Kukichūō, Saitama, Japan

Site Status

Saitama Clinical Site 2

Kumagaya, Saitama, Japan

Site Status

Tokyo Clinical Site 5

Bunkyo-ku, Tokyo, Japan

Site Status

Tokyo Clinical Site 9

Bunkyo-ku, Tokyo, Japan

Site Status

Tokyo Clinical Site1

Hachiōji, Tokyo, Japan

Site Status

Tokyo Clinical Site 7

Itabashi-ku, Tokyo, Japan

Site Status

Tokyo Clinical Site 3

Meguro-ku, Tokyo, Japan

Site Status

Tokyo Clinical Site 4

Shinagawa-ku, Tokyo, Japan

Site Status

Tokyo Clinical Site 8

Sibuya-ku, Tokyo, Japan

Site Status

Tokyo Clinical Site2

Sibuya-ku, Tokyo, Japan

Site Status

Tokyo Clinical Site 6

Tachikawa, Tokyo, Japan

Site Status

Okayama Clinical Site 1

Okayama, , Japan

Site Status

Osaka Clinical Site 1

Osaka, , Japan

Site Status

Countries

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Japan

References

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Kinoshita T, Shinoda M, Nishizaki Y, Shiraki K, Hirai Y, Kichikawa Y, Tsushima K, Shinkai M, Komura N, Yoshida K, Kido Y, Kakeya H, Uemura N, Kadota J. A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study). BMC Med. 2022 Sep 27;20(1):342. doi: 10.1186/s12916-022-02518-7.

Reference Type DERIVED
PMID: 36163020 (View on PubMed)

Other Identifiers

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FOY-305-01

Identifier Type: -

Identifier Source: org_study_id

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