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Analgesia aNd caNcer recUrrence Lung cAncer Resection

NCT ID: NCT04656769

Last Updated: 2020-12-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

382 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-17

Study Completion Date

2020-11-30

Brief Summary

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The choice of analgesia after cancer surgery may play a role in the onset of recurrence, particularly opioids seem to play a role in the immune system by promoting cancer cell proliferation and migration. Based on this consideration, our aim was to assess the impact of perioperative analgesia's choice on cancer recurrence after curative surgery for Stage I Non-Small Cell Lung Cancer. The investigators retrospectively reviewed the records of patients who underwent lung resection for Stage I NSCLC between January 2005 and December 2012. Patients received analgesia either by peridural (PERI group) or, in case of patient refusal or failure in catheter positioning, intravenous analgesia with opioids (EV group). Follow-up was concluded in August 2019. The five-year cumulative incidence of recurrence and the overall survival were evaluated and adjusted with a propensity score matching methodology.

Detailed Description

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Conditions

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Recurrence Tumor Opioid Use, Unspecified Analgesia Thoracic Surgery

Keywords

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Recurrence tumor Opioid use Analgesia thoracic surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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PERI group

Peridural analgesia

Intervention Type PROCEDURE

We attempted to evaluate the effectiveness of peridural analgesia through cancer survival and recurrence outcomes.

EV group

No interventions assigned to this group

Interventions

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Peridural analgesia

We attempted to evaluate the effectiveness of peridural analgesia through cancer survival and recurrence outcomes.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 yrs
* Patients who underwent lung resection for Stage I NSCLC between January 2005 and December 2012

Exclusion Criteria

* Age\<18aa
* Pregnancy
* Day hospital patients
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Turin, Italy

OTHER

Sponsor Role lead

Responsible Party

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Luca Brazzi

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Luca Brazzi, Professor

Role: STUDY_CHAIR

University of Torino

Giulio L Rosboch, MD

Role: PRINCIPAL_INVESTIGATOR

A.O.U. Città della Salute e della Scienza

Ilaria De Domenici, MD

Role: STUDY_DIRECTOR

University of Torino

Edoardo Ceraolo, MD

Role: PRINCIPAL_INVESTIGATOR

A.O.U. Città della Salute e della Scienza

Locations

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AOU Città della Salute e della Scienza di Torino

Torino, , Italy

Site Status

Countries

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Italy

Other Identifiers

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ANNULAR

Identifier Type: -

Identifier Source: org_study_id