Detection of Adenomas in Screening Colonoscopy

NCT ID: NCT04651062

Last Updated: 2020-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1178 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-01

Study Completion Date

2020-04-01

Brief Summary

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The Endocuff study aims to show an increase of the number of detected adenomas in screening colonoscopies when a endocuff vision (Arc Medical Design Ldt Leeds England) is used.

Detailed Description

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Endocuff is a relatively new device which is intended to be attached to the end of the colonoscope. Several minor studies have shown that the use of Endocuff probably increases the number of detected polyps in colonoscopy. Endocuff is made of soft plastic and has been designed to give an optimal view of the entire colon. It gently averts and flattens folds in order to see small polyps "hiding" in the space behind colonic folds.

The purpose of this study is to investigate into the effect of the Endocuff in screening colonoscopy compared with screening colonoscopy performed without Endocuff. The device has been used during several years yet an effect on the number of polyps detected during screenings colonoscopy has not been shown. This studies main hypothesis is that the use of Endocuff in screenings colonoscopy will increase the adenoma detection rate in these patients, with a potential to reduce interval cancer.

This study is a randomized controlled trial with 900 patients.

Conditions

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Adenoma Colon

Keywords

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adenoma detection rate screening colonoscopy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

this is a randomized controlled trial
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

participant, care provider, investigator and outcomes assessor know whether or not a endocuff has been used for the colonoscopy

Study Groups

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endocuff

all patients having performed a screeningscolonoscopy and being randomized to colonoscopy with the use of endocuff

Group Type EXPERIMENTAL

endocuff

Intervention Type DEVICE

Endocuff is a relatively new device which is intended to be attached to the end of the colonoscope.

no cuff

all patients participating in a screeningscolonoscopy being randomized to colonoscopy without the use of endocuff

Group Type ACTIVE_COMPARATOR

no endocuff

Intervention Type PROCEDURE

colonoscopy is performed without endocuff.

Interventions

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endocuff

Endocuff is a relatively new device which is intended to be attached to the end of the colonoscope.

Intervention Type DEVICE

no endocuff

colonoscopy is performed without endocuff.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* all Citizens participating in the national bowel screening program

Exclusion Criteria

* persons who are disabled and who do not understand the Danish language
* persons treated with Marcoumar, Marevan, Eliquis, Pradaxa e.g. and who are not eligible to polyp resection
* persons who due to diseases of the eyes or Heart are not allowed to receive Buscopan.
* persons with active colitis/diverticulitis, colon stenosis e.g. due to cancer, where a complete colonoscopy is not possible to achieve
Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Herning Hospital

OTHER

Sponsor Role lead

Responsible Party

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Claudia Jaensch

principan investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Kirurgisk Afdeling

Herning, Central Jutland, Denmark

Site Status

Countries

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Denmark

References

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Jaensch C, Jepsen MH, Christiansen DH, Madsen AH, Madsen MR. Adenoma and serrated lesion detection with distal attachment in screening colonoscopy: a randomized controlled trial. Surg Endosc. 2022 Sep;36(9):1-9. doi: 10.1007/s00464-022-09049-5. Epub 2022 Feb 9.

Reference Type DERIVED
PMID: 35141776 (View on PubMed)

Other Identifiers

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1-16-02-828-17

Identifier Type: -

Identifier Source: org_study_id