Surfactant Protein Genetic Variants in COVID-19 Infection

NCT ID: NCT04650191

Last Updated: 2022-09-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-01

Study Completion Date

2022-06-30

Brief Summary

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Surfactant protein plays important role in innate immunity against respiratory viral infections. However, investigators have shown that the surfactant protein polymorphisms are associated with severity of various pulmonary diseases such as respiratory syncytial virus (RSV), tuberculosis, pediatric acute lung injury. COVID-19 virus gains entry through the respiratory system and responsible for death due to acute respiratory failure. There is a considerable heterogeneity in presentation of COVID-19 infection from asymptomatic patients to severe infection requiring intensive care and some may die. Considering reports of COVID-19 related deaths/severe disease in the same family, it is possible that genetics play an important role in severity of COVID-19 infection. Investigators propose to study the association of surfactant proteins in COVID-19 patients. Key Objectives: a) Characterize genetic markers within the surfactant protein genes in COVID-19 positive patients, b) To determine if there is a correlation between certain genetic markers and the severity of COVID-19 infection which may be used as a prognostic marker, c) To correlate genetic markers with immune studies.

Detailed Description

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Conditions

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Coronavirus Infection

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Mild COVID-19 infection

Patients with confirmed COVID-19 infection who remained asymptomatic and/or never hospitalized.

Identification of genetic variants

Intervention Type OTHER

DNA will be extracted from whole blood from study subjects

Moderate COVID-19 infection

Patients with confirmed COVID-19 infection who got admitted in general ward in the hospital.

Identification of genetic variants

Intervention Type OTHER

DNA will be extracted from whole blood from study subjects

Severe COVID-19 infection

Patients with confirmed COVID-19 infection who got admitted in intensive care unit and/or did not survive.

Identification of genetic variants

Intervention Type OTHER

DNA will be extracted from whole blood from study subjects

Interventions

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Identification of genetic variants

DNA will be extracted from whole blood from study subjects

Intervention Type OTHER

Eligibility Criteria

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Exclusion Criteria

Patients unable to sign informed consent will be excluded.
Minimum Eligible Age

1 Day

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Milton S. Hershey Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Chintan Gandhi

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Milton S. Hershey Medical center

Hershey, Pennsylvania, United States

Site Status

Countries

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United States

Other Identifiers

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15456

Identifier Type: -

Identifier Source: org_study_id

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