Effect of a Mixture of Allium Extracts on LDL Cholesterol Levels Volunteers With Elevated LDL Cholesterol Levels

NCT ID: NCT04646382

Last Updated: 2023-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-01

Study Completion Date

2022-12-30

Brief Summary

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To evaluate the efficacy of daily consumption of a combination of concentrated extracts of garlic (Allium sativum L.) and onion (Allium cepa L.) on LDL cholesterol levels in healthy volunteers. Parameters related to metabolic syndrome, cardiovascular health and the immune system will also be analyzed.

Detailed Description

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It is a controlled, randomized, double-blind, parallel-group nutritional intervention study.

64 healthy volunteers lwith elevated LDL cholesterol levels but who do not require pharmacological treatment will be randomly distributed into 2 equal groups: control group and intervention group.

For 8 weeks the volunteers will take the product immediately after lunch. During that time they will maintain their lifestyle and nutritional habits.

Blood samples will be taken at 0, 2, 4 and 8 weeks. Anthropometric parameters and health-related data were also measured.

Parameters related to lipid metabolism, metabolic syndrome and the immune system will be analized.

Conditions

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Cardiovascular Health

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Controlled, randomized, double-blind, parallel group nutritional intervention study.
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Each volunteer is assigned a "participant number" that will be associated with a pot that will have all the product for the study.

The "pot number" is the same as the "participant number".

Study Groups

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Control

Microcrystalline cellulose (9892- Capsules®) up to 400 mg.

Group Type PLACEBO_COMPARATOR

Garlic and onion concentrate

Intervention Type DIETARY_SUPPLEMENT

Garlic extract concentrate (equivalent to 2 garlic cloves) and onion extract concentrate (equivalent to 1 onion).

Control

Intervention Type DIETARY_SUPPLEMENT

Microcrystalline cellulose

Intervention

Garlic concentrated extract. Onion concentrated extract. Microcrystalline cellulose (9892- Capsules®) up to 400 mg.

Group Type EXPERIMENTAL

Garlic and onion concentrate

Intervention Type DIETARY_SUPPLEMENT

Garlic extract concentrate (equivalent to 2 garlic cloves) and onion extract concentrate (equivalent to 1 onion).

Control

Intervention Type DIETARY_SUPPLEMENT

Microcrystalline cellulose

Interventions

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Garlic and onion concentrate

Garlic extract concentrate (equivalent to 2 garlic cloves) and onion extract concentrate (equivalent to 1 onion).

Intervention Type DIETARY_SUPPLEMENT

Control

Microcrystalline cellulose

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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AlioCare Excipient

Eligibility Criteria

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Inclusion Criteria

* LDL-cholesterol levels between 100 and 190 mg/dL.
* Freely agree to participate in the study and sign the informed consent document.

Exclusion Criteria

* Be pregnant.
* Have planned to change lifestyle and / or dietary habits.
* Having diabetes.
* Having a cerebrovascular disease.
* Having a serious illness.
* Taking products or drugs to control cholesterol levels or with antioxidant activity.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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DOMCA S.A.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Miguel Quesada, MD

Role: PRINCIPAL_INVESTIGATOR

Endocrinology and Nutrition Clinic of Dr. Miguel Quesada

Locations

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Domca Sau

Alhendín, Granada, Spain

Site Status

Countries

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Spain

Other Identifiers

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C003

Identifier Type: -

Identifier Source: org_study_id

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