Study of INCB086550 in Select Solid Tumors

NCT ID: NCT04629339

Last Updated: 2025-03-13

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-09-02
• Study Completion Date: 2024-03-26

Brief Summary

An open-label, nonrandomized study to evaluate the efficacy and safety of INCB086550, a first-in-class oral inhibitor of PD-L1, as initial immune checkpoint inhibitor therapy in participants with select solid tumors

Conditions

Non Small Cell Lung Cancer; Urothelial Cancer; Renal Cell Carcinoma; Hepatocellular Carcinoma; Melanoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

INCB086550

INCB086550 will be administered orally twice a day.

Group Type: EXPERIMENTAL

INCB086550

Intervention Type: DRUG

INCB086550 will be administered orally twice a day.

Interventions

INCB086550

INCB086550 will be administered orally twice a day.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Ability to comprehend and willingness to sign a written ICF for the study.
• Participants with following tumor types : non small cell lung cancer, renal cell carcinoma, urothelial carcinoma, hepatocellular carcinoma and melanoma
• Measurable disease per RECIST v1.1.
• ECOG performance status of 0 to 1 for all tumor types. Urothelial carcinoma allows ECOG of 0 to 2.
• Histologically or cytologically confirmed disease-specific diagnosis as per protocol.
• Willingness to avoid pregnancy or fathering children

Exclusion Criteria

• Prior receipt of an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent, or treatment with an immune modulator (eg, CTLA-4, GITR, LAG3, TIM3, OX40, ICOS, IL2, 4-1BB, CAR-T).
• Receipt of any anticancer therapy or participation in another interventional clinical study.
• Radiotherapy within 14 days of first dose of study treatment.
• Concomitant treatment with moderate and potent CYP3A4/CYP3A5 inhibitors or inducers.
• Toxicity of prior therapy that has not recovered to ≤ Grade 1 or baseline (with the exception of anemia not requiring transfusion support and any grade of alopecia). Endocrinopathy, if well-managed, is not exclusionary and should be discussed with the medical monitor.
• Participant has not recovered adequately from toxicities and/or complications from surgical intervention before starting study drug.
• Participants with laboratory values outside of protocol defined ranges Active malignancy of a type not included in the study population requiring treatment.
• Active autoimmune disease requiring systemic immunosuppression in excess of physiologic maintenance doses of corticosteroids (> 10 mg of prednisone or equivalent).
• Evidence of interstitial lung disease or active, noninfectious pneumonitis.
• Untreated or known active CNS metastases and/or carcinomatous meningitis.
• With the exception of participants with HCC, known active HAV, HBV, or HCV infection, as defined by elevated transaminases with the following serology: positivity for HAV IgM antibody, anti-HCV, anti-HBc IgG or IgM, or HBsAg (in the absence of prior immunization).
• Active infection requiring systemic therapy.
• Receipt of systemic antibiotics within 28 days of first dose of study treatment
• Probiotic usage during screening and throughout the study treatment period.
• Participants who are known to be HIV-positive.
• Participants with impaired cardiac function or clinically significant cardiac disease.
• History or presence of an ECG finding that, in the investigator's opinion, is clinically meaningful.
• Female participant is pregnant or breastfeeding within the projected duration of the study, starting with the screening visit through the 90-day safety follow-up, or male participant is expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 100 days after the last dose of study treatment.
• Has received a live vaccine within 90 days of the planned start of study drug.
• Current use of a prohibited medication as described in protocol.
• Life expectancy < 3 months.
• Known hypersensitivity or severe reaction to any component of study drug or formulation components.
• History of organ transplant, including allogeneic stem cell transplantation.
• Inability to swallow tablets or any condition of the upper gastrointestinal tract that precludes administration of oral medications.
• Any condition that would, in the investigator's judgment, interfere with full participation in the study, including administration of study drug and attending required study visits; pose a significant risk to the participant; or interfere with interpretation of study data.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Incyte Corporation

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Complex Oncology Center - Burgas Eood

Burgas, , Bulgaria

Multiprofile Hospital For Active Treatment "Dr. Tota Venkova" Jsc

Gabrovo, , Bulgaria

Complex Onclogy Center Plovdiv Eood

Plovdiv, , Bulgaria

Shatod Dr. Marko - Varna Ltd

Varna, , Bulgaria

Semmelweis Egyetem

Budapest, , Hungary

Complex Oncology Center - Burgas Eood

Farkasgyepű, , Hungary

Bacs Kiskun Megyei Oktatokorhaz

Kecskemét, , Hungary

The Catholic University of Korea St. Vincent'S Hospital

Gyeonggi-do, , South Korea

Korea University Anam Hospital

Seoul, , South Korea

Severance Hospital Yonsei University Health System

Seoul, , South Korea

Asan Medical Center

Seoul, , South Korea

Ajou University Hospital

Suwon, , South Korea

Chang Gung Memorial Hospital Linkou

Taoyuan, , Taiwan

Multifield Clinical Hospital No 4

Dnipro, , Ukraine

Ci of Healthcare Regional Clinical Specialized Dispensary of the Radiation Protection

Kharkiv, , Ukraine

Mi Kryviy Rih Center of Dnipropetrovsk Regional Council

Kryvyi Rih, , Ukraine

Volyn Regional Oncological Dispensary

Lutsk, , Ukraine

Rmi Sumy Regional Clinical Oncology Dispensary

Sumy, , Ukraine

Cne Ccch of Uzh Cc Oncological Center

Uzhhorod, , Ukraine

Medical Clinic Innovacia Llc

Vyshhorod, , Ukraine

Countries

Bulgaria; Hungary; South Korea; Taiwan; Ukraine

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

INCB 86550-203

Identifier Type: -

Identifier Source: org_study_id