Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120101 in Patients With Huntington's Disease
NCT ID: NCT04617847
Last Updated: 2022-02-09
Study Results
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View full resultsBasic Information
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TERMINATED
PHASE1/PHASE2
27 participants
INTERVENTIONAL
2020-04-13
2021-05-03
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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WVE-120101 (Dose A)
WVE-120101
WVE-120101 is a stereopure antisense oligonucleotide (ASO). It is administered monthly via intrathecal injection.
Interventions
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WVE-120101
WVE-120101 is a stereopure antisense oligonucleotide (ASO). It is administered monthly via intrathecal injection.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* 2\. Inability to undergo brain MRI (with or without sedation).
* 3\. Clinically significant medical finding on the physical examination other than HD that, in the judgment of the Investigator, will make the patient unsuitable for participation in and/or completion of the study procedures.
ALL
No
Sponsors
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Wave Life Sciences Ltd.
INDUSTRY
Responsible Party
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Principal Investigators
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Medical Director, MD
Role: STUDY_DIRECTOR
Wave Life Sciences
Locations
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Westmead Hospital
Sydney, New South Wales, Australia
Royal Brisbane & Women's Hospital
Herston, Queensland, Australia
Royal Melbourne Hospital
Carlton, Victoria, Australia
Monash Health
Clayton, Victoria, Australia
Alfred Health
Melbourne, Victoria, Australia
Calvary Health Care Bethlehem
Parkdale, Victoria, Australia
North Metropolitan Health Service
Perth, Western Australia, Australia
University of Alberta
Edmonton, Alberta, Canada
Centre Hospitalier de l-Universite de Montreal
Montreal, Quebec, Canada
Aarhus Universitets Hospital
Aarhus, , Denmark
Rigshospitalet
Copenhagen, , Denmark
Hospital Henri Mondor
Créteil, , France
Institut du Cerveau et de la Moelle Epinière
Paris, , France
George-Huntington-Institut GmbH
Münster, , Germany
Szpital Sw. Wojciecha
Gdansk, , Poland
Instytut Psychiatrii i Neurologii
Warsaw, , Poland
Royal Devon and Exeter Hospital NHS Trust
Exeter, Devon, United Kingdom
Queen Elizabeth University Hospital - PPDS
Glasgow, Glasgow City, United Kingdom
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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WVE-HDSNP1-002
Identifier Type: -
Identifier Source: org_study_id
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