Beneficial Side Effects of Topiramate in Obese Patients Undergoing Total Joint Arthroplasty
NCT ID: NCT04613024
Last Updated: 2025-04-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
EARLY_PHASE1
INTERVENTIONAL
2025-07-01
2027-07-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Experiment
Topamax randomized group
Topamax
Experiment randomized group will be prescribed Topamax before and after surgery with follow up at regular interval
Control
Gabapentin randomized group
Gabapentin
Control group will be prescribed gabapentin after surgery with follow up at regular interval
Interventions
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Topamax
Experiment randomized group will be prescribed Topamax before and after surgery with follow up at regular interval
Gabapentin
Control group will be prescribed gabapentin after surgery with follow up at regular interval
Eligibility Criteria
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Inclusion Criteria
* Patients refusing bariatric surgery or having had prior bariatric surgery
Exclusion Criteria
* known topiramate or gabapentin allergy
* history of seizure disorder
* chronic opiate use pre-operatively
* history of nephrolithiasis
* history of acute angle closure glaucoma
* recurrent major depression
* presence or history of suicidal behavior or ideation with intent to act
* current substantial depressive symptoms (Patient Health Questionnaire total score \>10), pregnancy
* child-bearing potential and not on contraception
* age \<18 years
* major neurocognitive disorder
* metabolic acidosis
* incarcerated status
* bilateral surgery
18 Years
40 Years
ALL
No
Sponsors
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Stanford University
OTHER
Responsible Party
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Derek Amanatullah
Assistnat professor
Locations
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Stanford University
Palo Alto, , United States Minor Outlying Islands
Countries
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Other Identifiers
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56915
Identifier Type: -
Identifier Source: org_study_id
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