TACE Plus HAIC With Oxaliplatin and Raltitrexed for BCLC Stage C HCC

NCT ID: NCT04597970

Last Updated: 2020-10-22

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 66 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-10-20
• Study Completion Date: 2022-10-20

Brief Summary

Purpose：explore the effectiveness and safety of transarterial chemoembolization (TACE) plus Hepatic Arterial Infusion Chemotherapy (HAIC) with oxaliplatin and raltitrexed for Barcelona stage C hepatocellular carcinoma (HCC)

Detailed Description

Thhis is a non-randomized, open, single-arm clinical study. patients receive cTACE+HAIC (oxaliplatin, raltitrexed) treatment, 6-8 weeks as a cycle, until the disease progresses, intolerable toxicity occurs, the patient is lost to follow-up or death, or situations other judged by researchers which treatment should be stopped.

Number of patients: 66 patients End points：primary end points：safety 、objective response rate，disease control rate，progression free overall survival，second end point ：overall survival Include criteria：

1. Volunteer to participate and sign the informed consent in writing;

2. Age: 18-75 years old;

3. No gender limit;

4. BCLC stage C hepatocellular carcinoma with pathological diagnosis or clinical diagnosis;

5. Barcelona stage C patients who failed first-line treatment (including but not limited to sorafenib, levatinib, atelizumab combined with bevacizumab, etc.); they have not received sorafenib in the past The patients treated by Sorafenib can receive sorafenib treatment at the same time, and the patients who have received sorafenib treatment progress can also receive regorafenib treatment.

6. At least one measurable lesion (according to mRECIST criteria) imaging diagnosis time ≤ 21 days from selection;

7. Child-pugh grade A-B7 grade

8. The expected survival period is ≥3 months;

9. ECOG Performance Status (ECOG) 0-2;

10. Sufficient bone marrow hematopoietic function (within 7 days): hemoglobin ≥9 g/dL, white blood cells ≥3.0×109/L, neutrophils ≥1.5x109/L, platelets ≥80x109/L; liver and kidney functions are normal (Within 14 days): TBIL≤1.5 times the upper limit of normal; ALT and AST≤5 times the upper limit of normal; creatinine≤1.5 times the upper limit of normal; INR<1.7 or prolonged PT<4s

Exclude criteria:

1. Those who are currently receiving other effective treatments;

2. Patients who have received oxaliplatin and raltitrexed in the past;

3. Patients who have participated in other clinical trials within 4 weeks before enrollment;

4. Unable to cooperate with cTACE and HAIC treatment;

5. Patients with primary malignant tumors other than hepatocellular carcinoma at the same time, except for cured skin basal cell carcinoma and cervical carcinoma in situ;

6. Clinically significant cardiovascular diseases, such as heart failure (NYHA III-IV), uncontrolled coronary heart disease, cardiomyopathy, arrhythmia, uncontrolled hypertension or a history of myocardial infarction within the past 1 year;

7. Neurological or mental abnormalities that affect cognitive ability, including central nervous system transfer;

8. There were active serious clinical infections (>grade 2 NCI-CTCAE version 4.0), including active tuberculosis within 14 days before enrollment;

9. Known or self-reported HIV infection;

10. Uncontrolled systemic diseases, such as poorly controlled diabetes;

11. Known to have hypersensitivity or allergic reactions to any component of the study drug;

12. Pregnancy (determined by serum β-chorionic gonadotropin test) or breast-feeding Treatment：patients receive cTACE+HAIC (oxaliplatin, raltitrexed) treatment, 6-8 weeks as a cycle, until the disease progresses, intolerable toxicity occurs, the patient is lost to follow-up or death, or situations other judged by researchers which treatment should be stopped.

Conditions

Transarterial Chemoembolization; Hepatocellular Carcinoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

cTACE-HAIC(oxaliplatin and raltitrexed)

Patients receive cTACE+HAIC (oxaliplatin, raltitrexed) treatment, 6-8 weeks as a cycle

Group Type: EXPERIMENTAL

cTACE-HAIC

Intervention Type: DRUG

transarterial chemoembolization (TACE) plus Hepatic Arterial Infusion Chemotherapy (HAIC) with oxaliplatin and raltitrexed for Barcelona stage C hepatocellular carcinoma (HCC)

Interventions

cTACE-HAIC

transarterial chemoembolization (TACE) plus Hepatic Arterial Infusion Chemotherapy (HAIC) with oxaliplatin and raltitrexed for Barcelona stage C hepatocellular carcinoma (HCC)

Intervention Type: DRUG

Other Intervention Names

OXRI

Eligibility Criteria

Inclusion Criteria

1. Volunteer to participate and sign the informed consent in writing;

2. Age: 18-75 years old;

3. No gender limit;

4. BCLC stage C hepatocellular carcinoma with clear pathological diagnosis or clinical diagnosis;

5. Barcelona stage C patients who failed first-line treatment (including but not limited to sorafenib, levatinib, atelizumab combined with bevacizumab, etc.); they have not received sorafenib in the past The patients treated by Sorafenib can receive sorafenib treatment at the same time, and the patients who have received sorafenib treatment progress can also receive regorafenib treatment.

6. At least one measurable lesion (according to mRECIST criteria) imaging diagnosis time ≤ 21 days from selection;

7. Child-pugh grade A-B7 grade

8. The expected survival period is ≥3 months;

9. General physical condition (ECOG) 0-2;

10. Sufficient bone marrow hematopoietic function (within 7 days): hemoglobin ≥9 g/dL, white blood cells ≥3.0×109/L, neutrophils ≥1.5x 109/L, platelets ≥80x 109/L; liver and kidney functions are normal (Within 14 days): TBIL≤1.5 times the upper limit of normal; ALT and AST≤5 times the upper limit of normal; creatinine≤1.5 times the upper limit of normal; INR<1.7 or prolonged PT<4s

Exclusion Criteria

1. Those who are currently receiving other effective treatments;

2. Patients who have received oxaliplatin and raltitrexed in the past;

3. Patients who have participated in other clinical trials within 4 weeks before enrollment;

4. Unable to cooperate with cTACE and HAIC treatment;

5. Patients with primary malignant tumors other than hepatocellular carcinoma at the same time, except for cured skin basal cell carcinoma and cervical carcinoma in situ;

6. Clinically significant cardiovascular diseases, such as heart failure (NYHA III-IV), uncontrolled coronary heart disease, cardiomyopathy, arrhythmia, uncontrolled hypertension or a history of myocardial infarction within the past 1 year;

7. Neurological or mental abnormalities that affect cognitive ability, including central nervous system transfer;

8. There were active serious clinical infections (>grade 2 NCI-CTCAE version 4.0), including active tuberculosis within 14 days before enrollment;

9. Known or self-reported HIV infection;

10. Uncontrolled systemic diseases, such as poorly controlled diabetes;

11. Known to have hypersensitivity or allergic reactions to any component of the study drug;

12. Pregnancy (determined by serum β-chorionic gonadotropin test) or breast-feeding

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Peking University Cancer Hospital & Institute

OTHER

Sponsor Role: lead

Responsible Party

Zhu Xu

Hospital Chief Physician，MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Xu Zhu

Role: PRINCIPAL_INVESTIGATOR

Peking University Cancer Hospital & Institute

Central Contacts

Xu Zhu

Role: CONTACT

drzhuxu@163.com

86-01088196059

Baojiang Liu

Role: CONTACT

lbjjrk@163.com

86-01088196059

Other Identifiers

2020YJZ41

Identifier Type: -

Identifier Source: org_study_id