The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content
NCT ID: NCT04581421
Last Updated: 2024-01-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2020-12-03
2022-06-15
Brief Summary
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Detailed Description
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The study involves 2 intervention periods of 5 days each, during which the participant ingests two different types of experimental diet. Participants will in randomized order (determined by block randomization) ingest a diet with low carbohydrate and high fat content, and a diet with high carbohydrate and low fat content.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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High Carb first
High Carb Low Fat Diet
The participants will be randomized to a diet of low carb/ high fat og high carb/low fat
Low Carb High Fat Diet
The participants will be randomized to a diet of low carb/ high fat og high carb/low fat
Low Carb first
High Carb Low Fat Diet
The participants will be randomized to a diet of low carb/ high fat og high carb/low fat
Low Carb High Fat Diet
The participants will be randomized to a diet of low carb/ high fat og high carb/low fat
Interventions
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High Carb Low Fat Diet
The participants will be randomized to a diet of low carb/ high fat og high carb/low fat
Low Carb High Fat Diet
The participants will be randomized to a diet of low carb/ high fat og high carb/low fat
Eligibility Criteria
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Inclusion Criteria
* Overweight (BMI 25-35)
* Low to moderate physical activity level, defined as ≤ 1 weekly session of aerobic exercise.
* Non-smokers
* No use of medicine
Exclusion Criteria
* HbA1C \>48 mmol/mol
* Fasting plasma triacylglycerol indicating dyslipidemia (≥2.2 mmol/l)
* FIB-4 score \>1.45
* Contraindications for MR-scan: abdominal height exceed limitations of the MR-scanner, pacemaker or other electronic device implanted, implanted metal devices, severe claustrophobia.
18 Years
50 Years
MALE
Yes
Sponsors
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University of Copenhagen
OTHER
Danish Research Centre for Magnetic Resonance
OTHER
Hvidovre University Hospital
OTHER
Responsible Party
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Kirstine Nyvold Bojsen-Moeller
Principal investigator, MD, PhD
Locations
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Amalie London
Hvidovre, , Denmark
Countries
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References
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London A, Richter MM, Sjoberg KA, Wewer Albrechtsen NJ, Povazan M, Drici L, Schaufuss A, Madsen L, Oyen J, Madsbad S, Holst JJ, van Hall G, Siebner HR, Richter EA, Kiens B, Lundsgaard A, Bojsen-Moller KN. The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycerol content in males with overweight and obesity: a randomized crossover study. Am J Clin Nutr. 2024 Aug;120(2):283-293. doi: 10.1016/j.ajcnut.2024.06.006. Epub 2024 Jun 22.
Other Identifiers
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LICARB ID PhD010-19.
Identifier Type: -
Identifier Source: org_study_id
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