Effects of a Paleolithic Lifestyle Intervention in Breast Cancer Patients Undergoing Radiotherapy

NCT ID: NCT04574323

Last Updated: 2020-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-03-19

Study Completion Date

2020-07-16

Brief Summary

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The study aims to test the feasibility and effects of a dietary and physical activity intervention based on evolutionary considerations in an oncological setting.

Detailed Description

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A total of 13 breast cancer patients referred to our clinic for curative radiotherapy were recruited for this pilot study. The women were supposed to undertake a "Paleolithic lifestyle" (PL) intervention consisting of a Paleolithic diet and daily outdoor activity of at least 30 min duration while undergoing radiotherapy. Body composition was measured weekly by bioimpedance analysis. Blood parameters were assessed before, during, and at the end of radiotherapy. A control group on an unspecified standard diet (SD) was assigned by propensity score matching.

Conditions

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Breast Cancer Body Weight Changes

Keywords

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Bioimpedance analysis Body composition Nutrition Oncology Paleolithic diet

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Paleolithic lifestyle group

The Paleolithic lifestyle (PL) intervention during radiotherapy consists of daily outdoor walks or bike rides of at least 30 min duration, preferably done at noon to maximize vitamin D production, and the adoption of a Paleolithic diet. For the outdoor activity, patients were told to not use sun screen. The Paleolithic diet prescription emphasized the consumption of fatty meats and organ meats from humanely raised animals, wild-caught fish, eggs, nuts and seeds, algae, spices, vegetables and fruits. Excluded were processed foods, grains of all types, legumes, vegetable oils except for native coconut and olive oil and dairy products except for ghee. No dietary supplements were allowed. Patients were supposed to start the PL intervention at least two days prior to the first irradiation and to protocol their food consumption on two days during the first week on the diet. They were also asked about their compliance to the PL intervention at each weekly measurement appointment.

Group Type EXPERIMENTAL

Curative radiotherapy

Intervention Type RADIATION

Standard curative radiotherapy

Paleolithic lifestyle intervention

Intervention Type OTHER

This intervention consists of daily outdoor walks or bike rides of at least 30 min duration, preferably done at noon to maximize vitamin D production, and the adoption of a Paleolithic diet. For the outdoor activity, patients were told to not use sun screen. The Paleolithic diet prescription emphasized the consumption of fatty meats and organ meats from humanely raised animals, wild-caught fish, eggs, nuts and seeds, algae, spices, vegetables and fruits. Excluded were processed foods, grains of all types, legumes, vegetable oils except for native coconut and olive oil and dairy products except for ghee. No dietary supplements were allowed.

Standard diet group

This group is on a standard diet while receiving radiotherapy.

Group Type OTHER

Curative radiotherapy

Intervention Type RADIATION

Standard curative radiotherapy

Interventions

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Curative radiotherapy

Standard curative radiotherapy

Intervention Type RADIATION

Paleolithic lifestyle intervention

This intervention consists of daily outdoor walks or bike rides of at least 30 min duration, preferably done at noon to maximize vitamin D production, and the adoption of a Paleolithic diet. For the outdoor activity, patients were told to not use sun screen. The Paleolithic diet prescription emphasized the consumption of fatty meats and organ meats from humanely raised animals, wild-caught fish, eggs, nuts and seeds, algae, spices, vegetables and fruits. Excluded were processed foods, grains of all types, legumes, vegetable oils except for native coconut and olive oil and dairy products except for ghee. No dietary supplements were allowed.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Body mass index \>18 kg/m\^2
* Karnofsky performance index \>60

Exclusion Criteria

* Metallic body parts
* Unable to comprehend the intervention
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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MVZ Leopoldina GmbH

OTHER

Sponsor Role lead

Responsible Party

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Dr. Rainer Klement

Principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Leopoldina Hospital Schweinfurt, Department of Radiotherapy and Radiation Oncology

Schweinfurt, Bavaria, Germany

Site Status

Countries

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Germany

References

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Klement RJ, Koebrunner PS, Krage K, Weigel MM, Sweeney RA. Short-term effects of a Paleolithic lifestyle intervention in breast cancer patients undergoing radiotherapy: a pilot and feasibility study. Med Oncol. 2020 Nov 28;38(1):1. doi: 10.1007/s12032-020-01443-0.

Reference Type RESULT
PMID: 33247817 (View on PubMed)

Other Identifiers

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2020-01

Identifier Type: -

Identifier Source: org_study_id