Clinical Efficacy of Combination Therapy Based on High-dose Biapenem in CRKP Infections

NCT ID: NCT04552444

Last Updated: 2020-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-06-01

Study Completion Date

2021-08-01

Brief Summary

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Carbapenem resistance is a high mortality rate of Klebsiella pneumoniae infection. It has been proved that high-dose carbapenem can reduce mortality and has a certain clinical effect. In this study, a high dose of biapenem was compared to determine whether it had a similar effect than meropenem.

Detailed Description

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Conditions

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High-dose Biapenem

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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the death group

Through the corresponding treatment, the patients who died within 28 days

Biapenem

Intervention Type DRUG

In the course of CRKP treatment, double dose biapenem was selected.

the survival group

Through the corresponding treatment, the patients who survived within 28 days

Biapenem

Intervention Type DRUG

In the course of CRKP treatment, double dose biapenem was selected.

Interventions

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Biapenem

In the course of CRKP treatment, double dose biapenem was selected.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* ICU hospitalized for more than 3 days;
* Biapenem used for more than 3 days

Exclusion Criteria

* Patients who refuse to be included in the group or pregnant women or under the age of 14 or ICU hospitalized for less than 3 days
Minimum Eligible Age

14 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Man Huang, Ph.D

Sponsor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The Second Affiliated Hospital of Zhejiang University Medical College

Hangzhou, Please Select, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Man Huang, Ph D

Role: CONTACT

+8613685753994

Facility Contacts

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Man Huang

Role: primary

+8613685753994

Other Identifiers

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SAHZU2017087

Identifier Type: -

Identifier Source: org_study_id

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