The Ideal LiST Session Frequency Protocol for CPPS Treatment

NCT ID: NCT04549389

Last Updated: 2021-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-03-02

Study Completion Date

2021-01-15

Brief Summary

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The study will include 50 chronic pelvic pain syndrome (CPPS) patients who will be randomised in 2 groups.

Group A (25 patients )will receive 6 LiST sessions with a frequency 1 session / week.

Group B (25 patients) will receive 6 LiST sessions with a frequency 2 sessions / week.

National Institutes of Health Chronic Prostatitis Symptom Index(NHI-CPSI), International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF-ED) questionnaires will be answered before and at 1 and 3 month follow up visit.

Adverse events will be reported during the treatment and follow up period.

Detailed Description

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Conditions

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Chronic Pelvic Pain Syndrome Chronic Non-bacterial Prostatitis Type IIIB

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Group A

Patients will receive 6 Low-intensity shockwave therapy (LiST) sessions (1/week) by using Dornier Aries 2 shockwave machine (energy level 7)

Group Type ACTIVE_COMPARATOR

Low intensity shockwave therapy

Intervention Type DEVICE

LiST will be applied in the perineum of the patients by using Dornier Aries 2 shockwave machine (5000shockwaves per session, energy level 7)

Group B

Patients will receive 6 Low-intensity shockwave therapy (LiST) sessions (2/week) by using Dornier Aries 2 shockwave machine (energy level 7)

Group Type ACTIVE_COMPARATOR

Low intensity shockwave therapy

Intervention Type DEVICE

LiST will be applied in the perineum of the patients by using Dornier Aries 2 shockwave machine (5000shockwaves per session, energy level 7)

Interventions

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Low intensity shockwave therapy

LiST will be applied in the perineum of the patients by using Dornier Aries 2 shockwave machine (5000shockwaves per session, energy level 7)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Participant must 18 to 60 years of age.
2. Participant has signed and dated the appropriate Informed Consent document.
3. Participant has had a clinical diagnosis of CP/CPPS defined as symptoms of discomfort or pain in the perineal or pelvic region for at least a three (3) month period within the last six (6) months

Exclusion Criteria

1. Participant has evidence of facultative Gram negative or enterococcus with a value of ≥ 1000 CFU/ml in mid-stream urine (VB2).
2. Participant has a history of prostate, bladder or urethral cancer.
3. Participant has undergone pelvic radiation or systemic chemotherapy.
4. Participant has undergone intravesical chemotherapy.
5. Participant has unilateral orchialgia without pelvic symptoms, active urethral stricture or bladder stones, or any other urological condition associated with LUTS, any neurological disease or disorder affecting the bladder.
6. Participant has undergone prostate surgery or treatment.
7. Participant with penile or urinary sphincter implants.
8. Participant has been diagnosed with cancer during the last 5 years, or had any surgery in the pelvis.
9. Participant has a neurological impairment or psychiatric disorder preventing his understanding of consent and his ability to comply with the protocol.
10. PSA\>3 and age \> 40 years
11. Positive (suspicious for malignancy) digital rectal examination (DRE).
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Institute for the Study of Urological Diseases, Greece

OTHER

Sponsor Role lead

Responsible Party

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Dimitrios Hatzichristou

President, Institute for the Study of Urological Diseases Theesaloniki, Greece

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dimitrios Hatzichristou, Professor

Role: PRINCIPAL_INVESTIGATOR

Institute for the Study of Urological Diseases, Thessaloniki, Greece

Locations

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G.Gennimatas Hospital

Thessaloniki, , Greece

Site Status

Countries

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Greece

Other Identifiers

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1410/2020

Identifier Type: -

Identifier Source: org_study_id

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