Effect of Antiplatelet Therapy on Cognition After Aneurysmal Subarachnoid Hemorrhage

NCT ID: NCT04548401

Last Updated: 2020-09-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-11-01

Study Completion Date

2021-12-31

Brief Summary

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Deficits in memory, executive function, and language are common cognitive sequelae of aneurysmal subarachnoid hemorrhage (aSAH). Previous study demonstrated that post-treatment antiplatelet therapy reduced risk for delayed cerebral ischemia caused by aSAH. However, the effect of antiplatelet therapy on cognition after aSAH is unclear. The aim of this study was to assess the effect of antiplatelet therapy on cognition after aSAH.

Detailed Description

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Conditions

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Aneurysmal Subarachnoid Hemorrhage

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Antiplatelet-N group

Patients with ruptured aneurysm underwent coiling alone, without post-treatment antiplatelet therapy

No interventions assigned to this group

Antiplatelet-Y group

Patients with ruptured aneurysm underwent stent assisted coiling, with post-treatment antiplatelet therapy (aspirin and/or clopidogrel or ticagrelor)

Antiplatelet Drug

Intervention Type DRUG

aspirin and/or clopidogrel or ticagrelor

Interventions

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Antiplatelet Drug

aspirin and/or clopidogrel or ticagrelor

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 1\. Patients with SAH in whom the aneurysm was proven by conventional angiography; 2. Baseline Hunt-Hess grade I-III; 3. patients received endovascular treatment

Exclusion Criteria

* 1\. Hunt-Hess grade IV-V; 2. Non-aneurysmal SAH; 3. Dementia in other diseases; 4. Lacking of 6-8 month MoCA evaluation.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nanjing Medical University

OTHER

Sponsor Role lead

Responsible Party

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Hai-Bin Shi

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hai Bin Shi, MD

Role: PRINCIPAL_INVESTIGATOR

The First Affiliated Hospital with Nanjing Medical University

Locations

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The First Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Zhen Yu Jia, MD.

Role: CONTACT

+86 13770918208

Facility Contacts

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Hai Bin Shi

Role: primary

Other Identifiers

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aSAH016

Identifier Type: -

Identifier Source: org_study_id

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