Validation of Pre-clinical Nano-Based Analgesics in Cells From Human Dorsal Root Ganglia

NCT ID: NCT04533919

Last Updated: 2025-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

8 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-16

Study Completion Date

2027-04-30

Brief Summary

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This study investigates the pre-clinical nano-based analgesics in cells from human dorsal root ganglia (clusters of neurons). Collecting these neurons may help future research related to safe and effective pain treatment.

Detailed Description

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PRIMARY OBJECTIVE:

I. To identify translational mechanisms and therapeutics for neuropathic pain, a type of chronic pain that can arise due to injured nerves.

OUTLINE:

Patients' leftover dorsal root ganglia samples are collected during standard of care surgery.

Conditions

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Spinal Cord Neoplasm

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Basic science (dorsal root ganglia collection)

Patients' leftover dorsal root ganglia samples are collected during standard of care surgery.

Biospecimen Collection

Intervention Type PROCEDURE

Undergo collection of dorsal root ganglia

Interventions

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Biospecimen Collection

Undergo collection of dorsal root ganglia

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

---All patients undergoing surgery to resect spinal tumors

Exclusion Criteria

---None
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

M.D. Anderson Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andrew J Shepherd

Role: PRINCIPAL_INVESTIGATOR

M.D. Anderson Cancer Center

Locations

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M D Anderson Cancer Center

Houston, Texas, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Andrew J. Shepherd

Role: CONTACT

713-745-7959

Facility Contacts

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Andrew J. Shepherd

Role: primary

713-745-7959

Related Links

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http://www.mdanderson.org

http://www.mdanderson.org

Other Identifiers

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NCI-2020-05249

Identifier Type: REGISTRY

Identifier Source: secondary_id

2020-0526

Identifier Type: OTHER

Identifier Source: secondary_id

2020-0526

Identifier Type: -

Identifier Source: org_study_id

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