Right Ventricular Function in End-stage Renal Disease Patients

NCT ID: NCT04524468

Last Updated: 2020-08-26

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 83 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-01-01
• Study Completion Date: 2020-07-01

Brief Summary

Right ventricular (RV) dysfunction is a major cause of heart failure and mortality in end-stage renal disease (ESRD) patients. The aim of the study was to evaluate the long-term impacts of different dialysis modalities on RV function assessed by conventional echocardiography in ESRD patients with preserved left ventricular function. The study included 83 ESRD patients grouped as follows: peritoneal dialysis (PD; n=46) and hemodialysis with brachial arterio-venous fistula (HD; n=37). Conventional echocardiography including 2D and tissue Doppler imaging was performed in all patients. Echocardiographic parameters were compared between groups.

Detailed Description

Cardiovascular diseases (CVD) are the main causes of death in patients undergoing dialysis. Right ventricular (RV) dysfunction is one of the major predictors of mortality and heart failure in this patient group. It has been shown that patients undergoing hemodialysis (HD) which is usually carried out via a surgically created arteriovenous fistula (AVF) have an increased risk for pulmonary hypertension and poorer right ventricular function compared with healthy controls . However, there are few data comparing the patients undergoing HD and peritoneal dialysis (PD), in terms of echocardiographic right ventricular function.

The aim of the present study was to elucidate the impact of both long term PD and HD therapy via brachial AVF on RV function in patients with preserved left ventricular (LV) function.

Patients undergoing dialysis were grouped as follows: 46 patients on PD and 37 patients on HD with brachial AVF. All of the study patients underwent transthoracic echocardiography. Left and right ventricular parameters were compared between two groups.

Conditions

Transthoracic Echocardiography; Hemodialysis

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

hemodialysis patients

end-stage renal disease patients on hemodialysis

Transthoracic echocardiography

Intervention Type: DIAGNOSTIC_TEST

Conventional 2-D transthoracic echocardiography was performed to all patients

peritoneal dialysis patients

end-stage renal disease patients on peritoneal dialysis

Transthoracic echocardiography

Intervention Type: DIAGNOSTIC_TEST

Conventional 2-D transthoracic echocardiography was performed to all patients

Interventions

Transthoracic echocardiography

Conventional 2-D transthoracic echocardiography was performed to all patients

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• End-stage renal disease patients on a regular dialysis program
• Being on dialysis at least 6 months
• >18 years old

Exclusion Criteria

• Ischemic heart disease
• Left ventricular systolic dysfunction with an ejection fraction (EF) of less than 55 %
• Valvulopathy
• Left bundle branch block
• Atrial fibrilation
• Previous renal transplantation
• Chronic obstructive pulmonary disease
• Interstitial lung diseases
• Connective tissue disorders
• Chronic thromboembolic disease
• Congenital left-to-right shunt
• Primary pulmonary hypertension

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Antalya Training and Research Hospital

OTHER_GOV

Sponsor Role: lead

Responsible Party

Duygu Ersan Demirci

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Duygu Ersan Demirci, MD

Role: PRINCIPAL_INVESTIGATOR

Antalya Research and Training Hospital

Locations

Antalya Research and Training Hospital

Antalya, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

2019-398

Identifier Type: -

Identifier Source: org_study_id