Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
300 participants
OBSERVATIONAL
2018-03-01
2023-12-31
Brief Summary
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Detailed Description
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A total of 300 Spanish subjects with asthma with and without a history of asthma exacerbations in the past 12 months will be recruited. Saliva, nasal and pharyngeal samples will be collected to study the oral cavity and the upper respiratory tract microbiome through next-generation sequencing technologies. Sequencing of the 16S ribosomal RNA (16S rRNA) gene will allow to characterize the bacterial diversity and abundance, as well as to infer the functionality of the microbiome in each sample. These parameters will be used to establish correlations between the microbiome and the presence of asthma exacerbations. Finally, the association between the genetic variation associated with exacerbations in genomic studies and the measurements of abundance, diversity and functions related to exacerbations will be jointly examined.
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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Controls
Asthma patients who did not report asthma exacerbations in the 12 months prior recruitment, defined by one of the following events because of asthma: oral corticosteroids use, emergency room visits, and/or hospitalizations.
No interventions assigned to this group
Cases
Asthma patients that reported asthma exacerbations in the 12 months prior recruitment, defined by one of the following events because of asthma: oral corticosteroids use, emergency room visits, and/or hospitalizations.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Physician diagnosis of asthma according to the Global Initiative for Asthma (GINA) guidelines
* Treated on GINA step 1-5
Exclusion Criteria
* Pregnancy
* Coexistence of other chronic pulmonary disorders including cystic fibrosis, chronic obstructive pulmonary disease (emphysema or chronic bronchitis), or congenital disorders of the lungs or airways
* Known family relatedness (first or second degree) with another participant already included in the study
8 Years
85 Years
ALL
No
Sponsors
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University of La Laguna
OTHER
Ministry of Science and Innovation, Spain
OTHER_GOV
Consorcio Centro de Investigación Biomédica en Red (CIBER)
OTHER_GOV
University Hospital of the Nuestra Señora de Candelaria
OTHER
Hospital Universitario de Canarias
OTHER
Hospital General de La Palma
UNKNOWN
Hospital Donostia
OTHER
Hospital Doctor Jose Molina Orosa
UNKNOWN
Maria Pino-Yanes
OTHER
Responsible Party
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Maria Pino-Yanes
Ramon y Cajal Fellow and Lecturer
Locations
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University of La Laguna
San Cristóbal de La Laguna, Santa Cruz De Tenerife, Spain
Hospital Doctor Jose Molina Orosa
Arrecife, , Spain
Hospital General de La Palma
Breña Alta, , Spain
Hospital Universitario de Canarias
San Cristóbal de La Laguna, , Spain
Hospital Universitario Donostia
San Sebastián, , Spain
Hospital Universitario Nuestra Señora de Candelaria
Santa Cruz de Tenerife, , Spain
Countries
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Central Contacts
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Facility Contacts
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Berta Roman-Bernal, MD
Role: primary
Jose M Hernandez-Perez, MD, Ph.D.
Role: primary
Ruperto Gonzalez-Perez, MD, Ph.D.
Role: primary
Olaia Sardon, MD, Ph.D.
Role: primary
Jose M Hernandez-Perez, MD, Ph.D.
Role: primary
Other Identifiers
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PI-29/17
Identifier Type: -
Identifier Source: org_study_id
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