Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
NCT ID: NCT04500002
Last Updated: 2020-08-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
240 participants
INTERVENTIONAL
2020-09-01
2021-07-30
Brief Summary
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Detailed Description
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Oral or vaginal misoprostol causes complete abortion in almost 85% of cases within seven days before the 12th week
Adjuvant isonicotinic acid hydrazide (INH) administration with misoprostol raises the rate of complete abortion
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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INH
3 tablets of isonicotinic acid hydrazide 300 mg will be given as single daily doses, 5 mg per day for two days at home and the third dose will be given on admission to hospital on day 3 and will be followed by vaginal misoprostol 800 mcg every three hours up to maximum three doses.
Isonicotinic Acid Hydrazide
total dose 900 mg per day for 3 days then Misoprosrol 800mcg will be given to all patients for induction of abortion
Misoprostol
Misoprosrol 800mcg will be given to all patients for induction of abortion
Misoprostol
Misoprostol Alone 800 mcg every three hours up to maximum three doses
Misoprostol
Misoprosrol 800mcg will be given to all patients for induction of abortion
Interventions
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Isonicotinic Acid Hydrazide
total dose 900 mg per day for 3 days then Misoprosrol 800mcg will be given to all patients for induction of abortion
Misoprostol
Misoprosrol 800mcg will be given to all patients for induction of abortion
Eligibility Criteria
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Inclusion Criteria
* Hemoglobin \>10 g/dL.
* BMI between 18.5 kg/m2 and 30 kg/m2.
* Missed abortion
Exclusion Criteria
* Fibroid uterus.
* Uterine anomalies.
* Coagulopathy.
* Medical disorder that contraindicate induction of abortion (e.g. heart failure).
* Previous attempts for induction of abortion in the current pregnancy.
* Allergy to misoprostol or letrozole.
* Scared uterus (previous myomectomy, cesarean section, hysterectomy and ruptured uterus).
18 Years
45 Years
FEMALE
No
Sponsors
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Aswan University Hospital
OTHER
Responsible Party
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hany farouk
A Professor
Locations
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Aswan University Hospital
Aswān, , Egypt
Countries
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Central Contacts
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Other Identifiers
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aswu/354/3/19
Identifier Type: -
Identifier Source: org_study_id
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