Misoprostol for Second Trimester Pregnancy Termination

NCT ID: NCT02669420

Last Updated: 2016-02-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2016-01-31

Brief Summary

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The majority of second-trimester pregnancy termination performed in the United States are performed surgically by dilation and evacuation. The frequency of induction of abortion increases as gestational age advances. In the late second trimester and early third trimester, induction is the primary method of termination in cases of fetal abnormalities. In many other countries, however, induction is the primary method of abortion throughout the second trimester

Detailed Description

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Conditions

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Intra Uterine Fetal Death

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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extra amniotic misoprostol

misoprostol dissolved in warm saline , become dissolute misoprostol saline solution(200 microgram every 4 hours)

Group Type EXPERIMENTAL

termination of second trimester pregnancy

Intervention Type PROCEDURE

Intra uterine extra amniotic (200 μg ) versus Vaginal (200 μg) Misoprostol for Second Trimester Pregnancy Termination. Randomized controlled trial

vaginal misoprostol

misoprostol tablet soaked with distilled water and inserted in the posterior fornix of the vagina( 200 microgram every 4 hours)

Group Type EXPERIMENTAL

termination of second trimester pregnancy

Intervention Type PROCEDURE

Intra uterine extra amniotic (200 μg ) versus Vaginal (200 μg) Misoprostol for Second Trimester Pregnancy Termination. Randomized controlled trial

Interventions

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termination of second trimester pregnancy

Intra uterine extra amniotic (200 μg ) versus Vaginal (200 μg) Misoprostol for Second Trimester Pregnancy Termination. Randomized controlled trial

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Pregnancy 13-24 weeks.
* Women with indication for termination of the pregnancy due to intra uterine fetal death

Exclusion Criteria

* Pregnancy beyond 24 weeks.
* Women with scared uterus.
* Known hypersensitivity for misoprostol.
* Refusal of the woman to participate.
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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abo bakr mitwally

lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tuncalp O, Lavelanet A, Gulmezoglu AM, Coomarasamy A, Gallos ID. Methods for managing miscarriage: a network meta-analysis. Cochrane Database Syst Rev. 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2.

Reference Type DERIVED
PMID: 34061352 (View on PubMed)

Other Identifiers

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220

Identifier Type: -

Identifier Source: org_study_id

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