Comparasion of Efficacy of Nebulized With Intravenous Magnesium Sulphate in Children With Asthma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

148 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-01

Study Completion Date

2020-09-30

Brief Summary

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The purpose of study is to assess the effectiveness of nebulized magnesium sulphate in children presenting with acute asthma.Study perfoma consists of demographic variables,exclusion criteria and pediatric asthma score that includes respiratory rate,SPO2 at room air(requirement of oxygen),auscultatory findings in chest,dysnea and retractions.

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Detailed Description

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After getting informed consent from guardian,148 patients of acute moderate ro severe asthma with pediatric asthma score 8-15 will be randomly classified into 2 groups and one group will receive nebulization with magnesium sulphate and other will receive intravenous magnesium sulphate and effectiveness will be compared by 4 point reduction in PAS from baseline in either groups after 6 hours.

Conditions

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Asthma in Children

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Nebulized magnesium sulphate

100mg of mgso4 in 20ml of normal saline via ultrasonic nebulizer

Group Type EXPERIMENTAL

Nebulized Magnesium sulfate

Intervention Type DRUG

MgSO4 100mg in 20 ml normal saline will be given via ultrasonic nebulizer over 10 minutes,and PAS score will be assessed at 30,60,120,240,360 minutes

Intravenous magnesium sulphate

Magnesium sulphate according to weight will be given intravenously.

Group Type EXPERIMENTAL

Intravenous magnesium sulphate

Intervention Type DRUG

pts age 2 to 12 years will receive intravenous magnesium sulphate 50 mg/kg over half hour

Interventions

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Nebulized Magnesium sulfate

MgSO4 100mg in 20 ml normal saline will be given via ultrasonic nebulizer over 10 minutes,and PAS score will be assessed at 30,60,120,240,360 minutes

Intervention Type DRUG

Intravenous magnesium sulphate

pts age 2 to 12 years will receive intravenous magnesium sulphate 50 mg/kg over half hour

Intervention Type DRUG

Other Intervention Names

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Nebulized MgSO4 IV MgSO4

Eligibility Criteria

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Inclusion Criteria

* patients with age 2 to 12 years with acute moderate to severe exacerbation of asthma as per operational definition children who are unrespoinsive to standard treatment of asthma at 60 minutes

Exclusion Criteria

* those with history of chronic lung disease and abnormal renal function contraindication for MgSO4 due to hepatic or renal disease allergy to MgSo4 children who has other comorbid illness

Minimum Eligible Age

2 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No