Effect of Dill in Thyroiditis and Nodular Goiter Patients
NCT ID: NCT04482907
Last Updated: 2020-07-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
68 participants
INTERVENTIONAL
2019-02-01
2020-04-05
Brief Summary
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The effect of Anethum graveolens L. was evaluated in euthyroid goiter patients diagnosed with benign thyroid nodule via fine needle aspiration biopsy. Aerial parts of Anethum graveolens L. were dried and grinded to yield a fine powder. Size 1 hydroxypropyl methylcellulose capsules were filled with 300 mg powder. Placebo was prepared in the same manner using maltodextrin. Patients were suggested to take 3 pills a day. Blood samples were collected at the initial and the final day for thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (Anti-Tg) and C-reactive protein (CRP) analysis. Nodule sizes were also measured at the beginning and at the end of the trial with ultrasonography to identify the changes and effectiveness of dill dosage forms.
After 90 days in the study, the status of TSH, fT3, fT4, anti-TPO and CRP levels were examined in the group with and without Anethum graveolens L..
Again, after the study, the size of thyroid nodules was evaluated in the group who received and did not receive Anethum graveolens L. by ultrasonography.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
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Group receiving dill
They took 3 meals a day, 3x300 mg dry dill powder by mouth. They bought dry dill powder for 90 days.
Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.
Tests from intravenous blood: TSH, fT3, fT4, anti-TPO, Anti-Tg, CRP
Group receiving placebo
They took 3 meals a day and 3 cellulose placebo capsules by mouth. They took placebo capsules for 90 days.
Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.
Tests from intravenous blood: TSH, fT3, fT4, anti-TPO, Anti-Tg, CRP
Interventions
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Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.
Tests from intravenous blood: TSH, fT3, fT4, anti-TPO, Anti-Tg, CRP
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* To be a benign result in fine needle aspiration biopsy,
* Euthyroid must be sick,
* Must be sick over the age of 18,
* To accept the research.
Exclusion Criteria
* To have a malignant result in thyroid biopsy,
* Not giving approval,
* To be renal failure,
* Benign pregnant,
* Taking blood thinning drugs
18 Years
76 Years
ALL
No
Sponsors
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Bezmialem Vakif University
OTHER
Responsible Party
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Principal Investigators
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Ayşegul Yabacı, research
Role: STUDY_CHAIR
Bezmialem Vakif University
Locations
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Sabahattin Destek
Fatih, Istanbul, Turkey (Türkiye)
Countries
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References
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Jana S, Shekhawat GS. Anethum graveolens: An Indian traditional medicinal herb and spice. Pharmacogn Rev. 2010 Jul;4(8):179-84. doi: 10.4103/0973-7847.70915.
Orhan IE, Senol FS, Ozturk N, Celik SA, Pulur A, Kan Y. Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions. Food Chem Toxicol. 2013 Sep;59:96-103. doi: 10.1016/j.fct.2013.05.053. Epub 2013 Jun 10.
Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P. Autoimmune thyroid disorders. Autoimmun Rev. 2015 Feb;14(2):174-80. doi: 10.1016/j.autrev.2014.10.016. Epub 2014 Oct 25.
Kratky J, Vitkova H, Bartakova J, Telicka Z, Antosova M, Limanova Z, Jiskra J. Thyroid nodules: pathophysiological insight on oncogenesis and novel diagnostic techniques. Physiol Res. 2014;63 Suppl 2(Suppl 2):S263-75. doi: 10.33549/physiolres.932818.
Yang ML, Lu B. Treatment of Goiter with Traditional Chinese Medicine Regimen Xing Qi Hua Ying Tang: A Clinical Study on 72 Patients with Multinodular and Diffuse Goiter. J Altern Complement Med. 2018 Apr;24(4):374-377. doi: 10.1089/acm.2017.0138. Epub 2017 Dec 7.
Altay M, Ates I, Kaplan Efe F, Karadag I. Does Use of Anethum Graveolens Affected Thyroid Hormone Levels and Thyroid Nodules? Am J Ther. 2017 Sep/Oct;24(5):e627-e629. doi: 10.1097/MJT.0000000000000511. No abstract available.
Other Identifiers
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12.2014/21
Identifier Type: -
Identifier Source: org_study_id
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