Clonal Hematopoiesis of Indeterminate Potential in Venous Thromboembolism

NCT ID: NCT04477564

Last Updated: 2025-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-07-03

Study Completion Date

2023-06-13

Brief Summary

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The aim of the study is to investigate the existence of clonal hematopoiesis of indeterminate potential (CHIP) in patients with a history of venous thromboembolism.

The study investigators make the assumption that these patients present mutations involved in CHIP occurrence.

Detailed Description

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Conditions

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Venous Thromboembolism

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

RETROSPECTIVE

Study Groups

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Unprovoked proximal deep vein thrombosis

No interventions assigned to this group

Provoked distal deep vein thrombosis

No interventions assigned to this group

age-matched control group with no history of vein thrombosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Men and women over 50 years old who have consulted at the Hematology laboratory of the Nîmes University Hospital for the occurrence or history of venous thromboembolism
* Patient who has accepted that their DNA was kept and used in the context of research on venous thromboembolism (biobank (registration number DC-2008-290 and authorization number AC-2008-107))

Exclusion Criteria

* Patients less than 50 years old
* Patient who has refused that their DNA was kept and used in the context of research on venous thromboembolism
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU de Nimes

Nîmes, , France

Site Status

Countries

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France

References

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Guillotin F, Mercier E, Fortier M, Bouvier S, Jacquet Q, Dallo M, Chea M, Bourguignon C, Cochery-Nouvellon E, Perez-Martin A, Gris JC. Clonal haematopoiesis of indeterminate potential in patients with venous thromboembolism. J Thromb Thrombolysis. 2023 Aug;56(2):351-354. doi: 10.1007/s11239-023-02836-4. Epub 2023 Jun 10.

Reference Type RESULT
PMID: 37300604 (View on PubMed)

Other Identifiers

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NIMAO/2020-01/SB-01

Identifier Type: -

Identifier Source: org_study_id

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