Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

NCT ID: NCT04468984

Last Updated: 2026-01-09

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 330 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-08-31
• Study Completion Date: 2026-12-31

Brief Summary

Myelofibrosis (MF) is a rare blood cancer, notable for scarring of the bone marrow (the spongy tissue inside bones) and the spleen becoming larger. The purpose of this study is to assess safety and change in spleen volume when navitoclax is given in combination with ruxolitinib, compared to best available therapy, for adult participants with MF.

Navitoclax is an investigational drug (not yet approved) being developed for the treatment of MF. Participants in this study will be randomly selected (like picking numbers out of a hat) to be in 1 of 2 treatment arms. Neither participants nor the study doctor will be able to pick which treatment arm a participants enters. In Arm A, participants will receive navitoclax in combination with ruxolitinib. In Arm B, participants will receive the best available therapy (BAT) for MF. In Arm C, participants will receive navitoclax. Adult participants with a diagnosis of MF that came back or did not get better after earlier treatment will be enrolled. Approximately 330 participants will be enrolled in approximately 322 sites across the world.

In Arm A, participants will receive navitoclax tablet by mouth once daily with by mouth ruxolitinib tablet twice daily. In Arm B, participants will receive the BAT available to the investigator. In Arm C, participants will receive navitoclax tablet by mouth once daily. Participants will receive the study drug until they experience no benefit (determined by the investigator), participants cannot tolerate the study drugs, or participants withdraw consent. The approximate treatment duration is about 3 years.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires.

Conditions

Myelofibrosis (MF)

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Arm A: Navitoclax + Ruxolitinib

Participants will receive navitoclax tablets once daily and ruxolitinib tablets twice daily.

Group Type: EXPERIMENTAL

Navitoclax

Intervention Type: DRUG

Tablet; Oral

Ruxolitinib

Intervention Type: DRUG

Tablet; Oral

Arm B: Best Available Therapy (BAT)

Participants will receive one of the BAT options, per the investigator's discretion.

Group Type: ACTIVE_COMPARATOR

Best Available Therapy (BAT)

Intervention Type: DRUG

Tablet/Capsule; Oral or Solution for Subcutaneous Injection

Arm C: Continued Access for Navitoclax

Participants will receive navitoclax tablets once daily.

Group Type: EXPERIMENTAL

Navitoclax

Intervention Type: DRUG

Tablet; Oral

Interventions

Navitoclax

Tablet; Oral

Intervention Type: DRUG

Ruxolitinib

Tablet; Oral

Intervention Type: DRUG

Best Available Therapy (BAT)

Tablet/Capsule; Oral or Solution for Subcutaneous Injection

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Must complete the Myelofibrosis Symptom Assessment Form (MFSAF) v4.0 on at least 4 out of the 7 days immediately prior to the date of randomization and must agree to collect MFSAF data daily by ePRO device during the study collection window.

-- Has at least 2 symptoms each with an average score >= 3 or an average total score of >= 12, as measured by the MFSAF v4.0.

• Documented diagnosis of primary myelofibrosis (MF) as defined by the World Health Organization (WHO) classification, post polycythemia vera (PPV)-MF, or post essential thrombocytopenia (PET)-MF, characterized by bone marrow fibrosis grades 2 or 3.
• Classified as intermediate-2 or high-risk MF, as defined by the Dynamic International Prognostic Scoring System Plus (DIPSS+).
• Must currently be on treatment or have received prior treatment with a single Janus Kinase 2 (JAK2) inhibitor, ruxolitinib, and meet one of the following criteria (in addition to the minimum splenomegaly and symptom burden also required for eligibility):

• Treatment with ruxolitinib for >= 24 weeks that was stopped due to lack of spleen response (refractory), or loss of spleen response or symptom control after a previous response (relapsed), or was continued despite relapsed/refractory status.
• Treatment with ruxolitinib for < 24 weeks with documented disease progression while on therapy as defined by any of the following:

• Appearance of new splenomegaly that is palpable to at least 5 cm below the left costal margin (LCM) in participants with no evidence of splenomegaly prior to the initiation of ruxolitinib.
• A >= 100% increase in the palpable distance below the LCM in participants with measurable spleen distance 5 to 10 centimeters (cm) prior to the initiation of ruxolitinib.
• A >= 50% increase in the palpable distance below the LCM in participants with measurable spleen distance > 10 cm prior to the initiation of ruxolitinib.
• A spleen volume increase of >= 25% (as assessed by Magnetic Resonance Imaging [MRI] or Computed Tomography [CT] scan) in participants with a spleen volume assessment prior to the initiation of ruxolitinib.
• Prior treatment with ruxolitinib of at least 10 mg twice daily (BID) for >= 28 days with intolerance defined as new RBC transfusion requirement (at least 2 units/month for 2 months) while receiving a total daily ruxolitinib dose of >= 30 mg but unable to reduce dose further due to lack of efficacy.

Note: Participant must not require a ruxolitinib dose less than 10 mg BID (20 mg daily) due to prior history of ruxolitinibrelated ≥ Grade 3 toxicity.

• Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.
• Splenomegaly defined as palpable spleen measurement >= 5 cm below left costal margin or spleen volume >= 450 cm3 as assessed centrally by MRI or CT scan.
• Baseline platelet count >= 100 × 10^9/L.

Exclusion Criteria

• Received prior treatment with a B-cell lymphoma 2 homology 3 (BH3)-mimetic compound, bromodomain and extra-terminal (BET) inhibitor, phosphoinositide 3- kinase and telomerase inhibitors (e.g., parsaclisib), prior use of > 1 JAK2 inhibitor or stem cell transplant.
• Eligible for stem cell transplantation at the time of study entry.
• Receiving medication that interferes with coagulation or platelet function within 3 days prior to the first dose of study drug or during the study treatment period except for low dose aspirin (up to 100 mg daily) and low molecular weight heparin (LMWH).
• Receiving anticancer therapy for an active malignancy or MF including chemotherapy, radiation therapy, hormonal therapy such that at least 5 half-lives of that medication is completed at least 7 days prior to the first dose of study drug or within 30 days prior to first dose of study drug, whichever is shorter, and during the study treatment period (other than any overlapping therapy as part of the selected BAT).

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

AbbVie

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

Ironwood Cancer & Res Ctr /ID# 222162

Chandler, Arizona, United States

Highlands Oncology Group, PA /ID# 221826

Springdale, Arkansas, United States

City of Hope /ID# 218996

Duarte, California, United States

Providence - St. Jude Medical Center /ID# 271382

Fullerton, California, United States

Moores Cancer Center /ID# 271596

La Jolla, California, United States

Moores Cancer Center at UC San Diego /ID# 219009

La Jolla, California, United States

Long Beach Memorial Medical Ct /ID# 224542

Long Beach, California, United States

Icri /Id# 221967

Whittier, California, United States

St. Mary's Hospital Regional Cancer Center /ID# 224229

Grand Junction, Colorado, United States

Augusta University Georgia Cancer Center /ID# 219051

Augusta, Georgia, United States

Columbus Regional Research Institute /ID# 224410

Columbus, Georgia, United States

University of Chicago Medical Center /ID# 271373

Chicago, Illinois, United States

Northwest Oncology & Hematology - Elk Grove Village /ID# 222818

Elk Grove Village, Illinois, United States

Loyola University Medical Ctr /ID# 219048

Maywood, Illinois, United States

Indiana Blood & Marrow Transpl /ID# 221587

Indianapolis, Indiana, United States

Tulane Medical Center - New Orleans /ID# 222940

New Orleans, Louisiana, United States

Duplicate_Ochsner Clinic Foundation-New Orleans /ID# 222777

New Orleans, Louisiana, United States

American Oncology Partners of Maryland /ID# 222836

Bethesda, Maryland, United States

Dana-Farber Cancer Institute /ID# 218998

Boston, Massachusetts, United States

University of Michigan /ID# 218463

Ann Arbor, Michigan, United States

Henry Ford Hospital /ID# 221190

Detroit, Michigan, United States

William Beaumont Hospital /ID# 222705

Royal Oak, Michigan, United States

Saint Louis University Cancer Center /ID# 222287

St Louis, Missouri, United States

Summit Medical Group-Florham Park /ID# 222620

Florham Park, New Jersey, United States

Hackensack Univ Med Ctr /ID# 219047

Hackensack, New Jersey, United States

The Cancer Institute at St. Francis Hospital /ID# 231782

Greenvale, New York, United States

Manhattan Hematology Oncology MHO Associates /ID# 223193

New York, New York, United States

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 221081

New York, New York, United States

Atrium Health Wake Forest Baptist Medical Center /ID# 222899

Winston-Salem, North Carolina, United States

MetroHealth Medical Center /ID# 222650

Cleveland, Ohio, United States

Pennsylvania Cancer Specialists & Research Institute /ID# 271376

Gettysburg, Pennsylvania, United States

Hospital of the University of Pennsylvania /ID# 219001

Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center /ID# 223955

Philadelphia, Pennsylvania, United States

Texas Oncology - Abilene - Antilley Road /ID# 271379

Abilene, Texas, United States

Duplicate_Houston Methodist Hospital /ID# 223103

Houston, Texas, United States

University of Texas Health San Antonio MD Anderson Cancer Center /ID# 233942

San Antonio, Texas, United States

Utah Cancer Specialists Salt Lake Clinic /ID# 221962

Salt Lake City, Utah, United States

Virginia Cancer Specialists - Fairfax /ID# 223016

Fairfax, Virginia, United States

Providence Everett /ID# 223130

Everett, Washington, United States

Yakima Valley Memorial Hosp /ID# 224368

Yakima, Washington, United States

HSHS St. Vincent Hospital /ID# 224468

Green Bay, Wisconsin, United States

The Kinghorn Cancer Centre /ID# 221097

Darlinghurst, New South Wales, Australia

Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 223848

East Albury, New South Wales, Australia

Calvary Mater Newcastle /ID# 224324

Waratah, New South Wales, Australia

The Alfred Hospital /ID# 221096

Melbourne, Victoria, Australia

Royal Perth Hospital /ID# 221099

Perth, Western Australia, Australia

Universitaetsklinikum St. Poelten /ID# 221709

Sankt Pölten, Lower Austria, Austria

Medizinische Universitaet Graz /ID# 220919

Graz, Styria, Austria

Ordensklinikum Linz GmbH Elisabethinen /ID# 220914

Linz, Upper Austria, Austria

Klinikum Wels-Grieskirchen GmbH /ID# 220915

Wels, Upper Austria, Austria

Medizinische Universitaet Wien /ID# 220911

Vienna, Vienna, Austria

Hanusch Krankenhaus /ID# 220912

Vienna, , Austria

ZAS Cadix /ID# 221468

Antwerp, Antwerpen, Belgium

Cliniques Universitaires UCL Saint-Luc /ID# 224221

Brussels, Brussels Capital, Belgium

Grand Hôpital de Charleroi - Les Viviers /ID# 224827

Charleroi, Hainaut, Belgium

UZ Gent /ID# 220841

Ghent, Oost-Vlaanderen, Belgium

Vitaz /Id# 228150

Sint-Niklaas, Oost-Vlaanderen, Belgium

AZ-Delta /ID# 221469

Roeselare, West-Vlaanderen, Belgium

UMHAT Alexandrovska EAD /ID# 231652

Sofiya, Sofia, Bulgaria

UMHAT Dr Georgi Stranski EAD /ID# 231650

Pleven, , Bulgaria

Acibadem City Clinic Tokuda University Hospital EAD /ID# 231649

Sofia, , Bulgaria

UMHAT Sveti Ivan Rilski /ID# 231651

Sofia, , Bulgaria

UMHAT Sveta Marina /ID# 234119

Varna, , Bulgaria

Juravinski Cancer Centre /ID# 220887

Hamilton, Ontario, Canada

Ottawa Hospital Research Institute /ID# 238858

Ottawa, Ontario, Canada

University Health Network_Princess Margaret Cancer Centre /ID# 253942

Toronto, Ontario, Canada

CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433

Lévis, Quebec, Canada

McGill University Health Centre - Glen Site /ID# 222614

Montreal, Quebec, Canada

CHUQ- Hôpital de l'Enfant-Jesus /ID# 220888

Québec, Quebec, Canada

Clinical Hospital Dubrava /ID# 230801

Zagreb, City of Zagreb, Croatia

Klinicka bolnica Merkur /ID# 230799

Zagreb, City of Zagreb, Croatia

Klinicki bolnicki centar Zagreb /ID# 230798

Zagreb, City of Zagreb, Croatia

Klinicki bolnicki centar Osijek /ID# 231503

Osijek, County of Osijek-Baranja, Croatia

Klinicki Bolnicki Centar (KBC) Split /ID# 230800

Split, Split-Dalmatia County, Croatia

Fakultní Nemocnice Brno - Jihlavská /ID# 220959

Brno, Brno-mesto, Czechia

Vseobecna fakultni nemocnice v Praze /ID# 220969

Prague, , Czechia

Aalborg University Hospital /ID# 224391

Aalborg, North Denmark, Denmark

Roskilde Sygehus /ID# 224456

Roskilde, Region Sjælland, Denmark

Duplicate_CHU DE NICE-HOPITAL LARCHET II /ID# 256291

Nice, Alpes-Maritimes, France

CHU NIMES - Hopital Caremeau /ID# 219128

Nîmes, Gard, France

Centre Hospitalier Universitaire de Bordeaux /ID# 222696

Pessac, Gironde, France

CHU de Nantes, Hotel Dieu -HME /ID# 219127

Nantes, Pays de la Loire Region, France

HCL - Hopital Lyon Sud /ID# 222695

Pierre-Bénite, Rhone, France

Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 223771

Chambéry, Savoie, France

Chu Angers /Id# 219129

Angers, , France

Hôpital Saint-Louis /ID# 221390

Paris, , France

Hopital Avicenne - APHP /ID# 221287

Bobigny, Île-de-France Region, France

Universitatsklinikum Mannheim /ID# 221529

Mannheim, Baden-Wurttemberg, Germany

Stauferklinikum Schwaebisch Gmuend /ID# 223948

Mutlangen, Baden-Wurttemberg, Germany

Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 225025

Augsburg, Bavaria, Germany

Universitaetsmedizin Rostock /ID# 224157

Rostock, Mecklenburg-Vorpommern, Germany

Augusta-Kranken-Anstalt gGmbH, Bochum-Mitte /ID# 224695

Bochum, North Rhine-Westphalia, Germany

Klinikum Chemnitz gGmbH /ID# 224575

Chemnitz, Saxony, Germany

BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221346

Dresden, Saxony, Germany

OncoResearch Lerchenfeld GmbH /ID# 225034

Hamburg, , Germany

Klinikum rechts der Isar /ID# 221526

Munich, , Germany

Olympion General Clinic /ID# 261423

Pátrai, Achaia, Greece

General Hospital of Athens Laiko /ID# 221175

Athens, Attica, Greece

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179

Athens, , Greece

University General Hospital of Patras /ID# 221178

RION Patras Achaia, , Greece

General Hospital of Thessaloniki George Papanikolaou /ID# 221463

Thessaloniki, , Greece

Fejér Vármegyei Szent György Egyetemi Oktató Kórház /ID# 220949

Székesfehérvár, Fejér, Hungary

Debreceni Egyetem-Klinikai Kozpont /ID# 220947

Debrecen, Hajdú-Bihar, Hungary

Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 220948

Kaposvár, Somogy County, Hungary

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 220946

Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary

Szegedi Tudományegyetem /ID# 220955

Szeged, , Hungary

Yitzhak Shamir Medical Center /ID# 222972

Ẕerifin, Central District, Israel

HaEmek Medical Center /ID# 220839

Afula, H_efa, Israel

Rambam Health Care Campus /ID# 219121

Haifa, H_efa, Israel

The Lady Davis Carmel Medical Center /ID# 222973

Haifa, H_efa, Israel

Hadassah Medical Center-Hebrew University /ID# 219111

Jerusalem, Jerusalem, Israel

Hadassah Mt. Scopus /ID# 253394

Jerusalem, Jerusalem, Israel

Galilee Medical Center /ID# 225280

Nahariya, Northern District, Israel

Duplicate_Assuta Ashdod Medical Center /ID# 225281

Ashdod, Southern District, Israel

The Chaim Sheba Medical Center /ID# 219136

Ramat Gan, Tel Aviv, Israel

Tel Aviv Sourasky Medical Center /ID# 219135

Tel Aviv, Tel Aviv, Israel

Rabin Medical Center /ID# 219139

Petah Tikva, , Israel

Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 221077

Bologna, Emilia-Romagna, Italy

Azienda Ospedaliero Universitaria Careggi /ID# 219090

Florence, Firenze, Italy

Duplicate_Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita /ID# 219087

Rome, Lazio, Italy

Fondazione IRCCS San Gerardo dei Tintori - Ospedale San Gerardo /ID# 225113

Monza, Monza E Brianza, Italy

Azienda Ospedaliera Universitaria Federico II /ID# 224673

Naples, Napoli, Italy

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 221223

Turin, Piedmont, Italy

Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 225731

Rome, Roma, Italy

Azienda Ospedaliero Universitaria delle Marche /ID# 238438

Ancona, , Italy

ASST Papa Giovanni XXIII /ID# 221222

Bergamo, , Italy

AOU Policlinico G. Rodolico - San Marco /ID# 219089

Catania, , Italy

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone /ID# 221078

Palermo, , Italy

Grande Ospedale Metropolitano Bianchi - Melacrino - Morelli P.O. Riuniti /ID# 221220

Reggio Calabria, , Italy

Duplicate_University Hospital Santa Maria della Misericordia /ID# 221241

Udine, , Italy

ASST Sette Laghi - Ospedale Di Circolo E Fondazione Macchi Varese /ID# 234183

Varese, , Italy

Azienda ULSS 8 Berica /ID# 221079

Vicenza, , Italy

Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 221150

Nagoya, Aichi-ken, Japan

Fujita Health University Hospital /ID# 221598

Toyoake, Aichi-ken, Japan

Aomori Prefectural Central Hospital /ID# 221778

Aomori, Aomori, Japan

Chiba University Hospital /ID# 224546

Chiba, Chiba, Japan

National Cancer Center Hospital East /ID# 226653

Kashiwa-shi, Chiba, Japan

Ehime University Hospital /ID# 221158

Toon-shi, Ehime, Japan

Kyushu University Hospital /ID# 221606

Fukuoka, Fukuoka, Japan

Fukushima Medical University Hospital /ID# 221877

Fukushima, Fukushima, Japan

Gifu University Hospital /ID# 224371

Gifu, Gifu, Japan

Sapporo Hokuyu Hospital /ID# 221149

Sapporo, Hokkaido, Japan

Kobe City Medical Center General Hospital /ID# 221156

Kobe, Hyōgo, Japan

Kanazawa University Hospital /ID# 223028

Kanazawa, Ishikawa-ken, Japan

Iwate Medical University Hospital /ID# 222044

Shiwa-gun, Iwate, Japan

Shonan Kamakura General Hospital /ID# 223030

Kamakura-shi, Kanagawa, Japan

Kumamoto Shinto General Hospital /ID# 255645

Kumamoto, Kumamoto, Japan

Kyoto University Hospital /ID# 223008

Kyoto, Kyoto, Japan

Mie University Hospital /ID# 221665

Tsu, Mie-ken, Japan

University of Miyazaki Hospital /ID# 221821

Miyazaki, Miyazaki, Japan

Niigata University Medical & Dental Hospital /ID# 223034

Niigata, Niigata, Japan

Kurashiki Central Hospital /ID# 221690

Kurashiki-shi, Okayama-ken, Japan

Kansai Medical University Hospital /ID# 257289

Hirakata-shi, Osaka, Japan

The University of Osaka Hospital /ID# 221159

Suita-shi, Osaka, Japan

Dokkyo Medical University Saitama Medical Center /ID# 222334

Koshigaya, Saitama, Japan

Juntendo University Shizuoka Hospital /ID# 221780

Izunokuni-shi, Shizuoka, Japan

Juntendo University Hospital /ID# 221154

Bunkyo-ku, Tokyo, Japan

Nippon Medical School Hospital /ID# 221676

Bunkyo-ku, Tokyo, Japan

Tokyo Medical University Hospital /ID# 221540

Shinjuku-ku, Tokyo, Japan

Tokyo Metropolitan Bokutoh Hospital /ID# 254774

Sumida-ku, Tokyo, Japan

University of Yamanashi Hospital /ID# 221706

Chuo-shi, Yamanashi, Japan

IMSUT Hospital, The Institute of Medical Science, The University of Tokyo /ID# 257944

Tokyo, , Japan

Aotearoa Clinical Trials /ID# 232201

Papatoetoe, Auckland, New Zealand

ARS-MEDICAL Sp. z o.o. /ID# 238336

Piła, Greater Poland Voivodeship, Poland

Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola /ID# 241031

Poznan, Greater Poland Voivodeship, Poland

SP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160

Krakow, Lesser Poland Voivodeship, Poland

Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie /ID# 221124

Lublin, Lublin Voivodeship, Poland

Lux Med Onkologia - Szpital Szamocka /Id# 221265

Warsaw, Masovian Voivodeship, Poland

MTZ Clinical Research Powered by Pratia /ID# 221759

Warsaw, Masovian Voivodeship, Poland

Uniwersyteckie Centrum Kliniczne /ID# 221298

Gdansk, Pomeranian Voivodeship, Poland

Pratia Onkologia Katowice /ID# 224526

Katowice, , Poland

Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopern /ID# 221161

Lodz, Łódź Voivodeship, Poland

Hospital del Centro Comprensivo de Cancer de la UPR /ID# 223281

San Juan, , Puerto Rico

Moscow State budget healthcare /ID# 221116

Moscow, Moscow, Russia

Clinic UZI 4D /ID# 221303

Pyatigorsk, Stavropol Kray, Russia

Hospital n.a. V.V. Veresaev /ID# 225221

Moscow, , Russia

Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221115

Saint Petersburg, , Russia

Almazov National Medical Research Centre /ID# 221114

Saint Petersburg, , Russia

Tula Regional Clinical Hospital /ID# 221302

Tula, , Russia

University Clinical Center Serbia /ID# 231058

Belgrade, Beograd, Serbia

Clin Hosp Ctr Bezanijska Kosa /ID# 231059

Belgrade, Beograd, Serbia

University Clinical Center Vojvodina /ID# 231057

Novi Sad, , Serbia

Duplicate_Wits Clinical Research Site /ID# 231554

Johannesburg, Gauteng, South Africa

Alberts Cellular Therapy /ID# 231556

Pretoria, Gauteng, South Africa

Pusan National University Hospital /ID# 220980

Busan, Busan Gwang Yeogsi, South Korea

Gachon University Gil Medical Center /ID# 220972

Incheon, Gyeonggido, South Korea

Seoul National University Hospital /ID# 219060

Seoul, Seoul Teugbyeolsi, South Korea

Samsung Medical Center /ID# 221091

Seoul, Seoul Teugbyeolsi, South Korea

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219061

Seoul, Seoul Teugbyeolsi, South Korea

Complejo Hospitalario Universitario A Coruña /ID# 224617

A Coruña, A Coruna, Spain

Duplicate_Hospital Clínico Universitario de Santiago-CHUS /ID# 221616

Santiago de Compostela, A Coruna, Spain

Hospital Universitario Germans Trias i Pujol /ID# 233727

Badalona, Barcelona, Spain

Hospital Universitario Dr. Negrin /ID# 220923

Las Palmas de Gran Canaria, Las Palmas, Spain

Hospital Universitario Central de Asturias /ID# 224815

Oviedo, Principality of Asturias, Spain

Hospital Parc de Salut del Mar /ID# 220922

Barcelona, , Spain

Hospital Universitario Vall d'Hebron /ID# 240979

Barcelona, , Spain

Hospital Universitario Virgen de las Nieves /ID# 253936

Granada, , Spain

Hospital Universitario 12 de Octubre /ID# 233726

Madrid, , Spain

Hospital Universitario La Paz /ID# 224813

Madrid, , Spain

Hospital Regional Universitario de Malaga /ID# 221906

Málaga, , Spain

Hospital Universitario de Salamanca /ID# 221904

Salamanca, , Spain

Hospital Universitario Virgen del Rocio /ID# 221932

Seville, , Spain

Hospital Clinico Universitario de Valencia /ID# 220920

Valencia, , Spain

Skane University Hospital Lund /ID# 220834

Lund, Skåne County, Sweden

Duplicate_Universitätsspital Basel /ID# 221261

Basel, Canton of Basel-City, Switzerland

Inselspital, Universitaetsspital Bern /ID# 223439

Bern, , Switzerland

Kaohsiung Chang Gung Memorial Hospital /ID# 218985

Kaohsiung City, Kaohsiung, Taiwan

Chi Mei Hospital - Liouying /ID# 221144

Tainan, Tainan, Taiwan

National Taiwan University Hospital /ID# 271207

Taipei City, Taipei, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980

Kaohsiung City, , Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 271389

Kaohsiung City, , Taiwan

China Medical University Hospital /ID# 218979

Taichung, , Taiwan

National Cheng Kung University Hospital /ID# 271206

Tainan, , Taiwan

Taipei Veterans General Hosp /ID# 221147

Taipei, , Taiwan

Linkou Chang Gung Memorial Hospital /ID# 218982

Taoyuan, , Taiwan

Medipol Mega Üniversite Hastanesi /ID# 271374

Tuzla, Istanbul, Turkey (Türkiye)

Gulhane Askeri Tip Academy /ID# 224568

Ankara, , Turkey (Türkiye)

Hacettepe Universitesi Hastaneleri /ID# 271084

Ankara, , Turkey (Türkiye)

Trakya University Medical Facu /ID# 224572

Edirne, Istanbul, , Turkey (Türkiye)

Ege University Medical Faculty /ID# 224570

Izmir, , Turkey (Türkiye)

Mersin University Medical /ID# 224571

Mersin, , Turkey (Türkiye)

Ondokuz mayis University Facul /ID# 224567

Samsun, , Turkey (Türkiye)

Feofaniya Clinical Hospital of State Management of Affairs /ID# 271397

Kyiv, , Ukraine

Dup_Guys and St Thomas NHS Foundation Trust - Guy's Hospital /ID# 221041

London, Greater London, United Kingdom

United Lincolnshire Hospitals NHS Trust /ID# 224613

Lincoln, Lincolnshire, United Kingdom

James Paget University Hospitals NHS Foundation Trust /ID# 221219

Great Yarmouth, Norfolk, United Kingdom

University Hospitals Birmingham NHS Foundation Trust /ID# 221334

Birmingham, , United Kingdom

NHS Lothian /ID# 224378

Edinburgh, , United Kingdom

The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 221335

Newcastle upon Tyne, , United Kingdom

Countries

United States; Australia; Austria; Belgium; Bulgaria; Canada; Croatia; Czechia; Denmark; France; Germany; Greece; Hungary; Israel; Italy; Japan; New Zealand; Poland; Puerto Rico; Russia; Serbia; South Africa; South Korea; Spain; Sweden; Switzerland; Taiwan; Turkey (Türkiye); Ukraine; United Kingdom

Other Identifiers

2023-507273-18-00

Identifier Type: OTHER

Identifier Source: secondary_id

M20-178

Identifier Type: -

Identifier Source: org_study_id