Effectiveness and Safety of Generic Delayed-Release Dimethyl Fumarate (Sclera® or Marovarex ®, Hikma) in Routine Medical Practice in the Treatment of Relapsing-Remitting Multiple Sclerosis in MENA Region

NCT ID: NCT04468165

Last Updated: 2023-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-23

Study Completion Date

2023-07-20

Brief Summary

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The purpose of this observational study is to evaluate the effectiveness, safety and health related quality of life of Generic DMF (Sclera® or Marovarex ®, Hikma) in patients undergoing routine clinical care for RRMS in MENA Region

Detailed Description

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This is an observational, multi-center, prospective, cohort study, where no visits or intervention(s) additional to the daily practice will be performed. In the study sites, patients undergoing routine clinical care for RRMS and initiated treatment with Generic DMF (Sclera® or Marovarex ®, Hikma) in accordance with the approved SPC will be followed up and assessed for a total of 12 months.

Conditions

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Relapsing Remitting Multiple Sclerosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Dimethyl Fumarate (DMF)

Gastro-resistant Hard Capsules. Each capsule contains 240mg or 120mg Dimethyl Fumarate

Intervention Type DRUG

Other Intervention Names

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Sclera ®, Hikma Marovarex ®, Hikma

Eligibility Criteria

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Inclusion Criteria

1. Patients who initiate treatment with Hikma Generic DMF at baseline in accordance with the approved Summary of Product Characteristics
2. Age ≥ 18 years
3. Patients who had a diagnosis of RRMS per 2010 or 2017 revised McDonald criteria who are :

1. Newly diagnosed who had no prior DMT, or
2. Switched patients who had ≥1 prior DMTs, other than DMF
4. Patients who agree to participate in the study and provide a written informed consent

Exclusion Criteria

1. Patients with previous exposure to DMF other than (Sclera® or Marovarex ®-Hikma), Fumaderm (fumaric acid esters), or compounded fumarates.
2. Patients participating in other clinical studies
3. Patients who meet any of the contraindications to the administration of the Study drug according to the approved Summary of Product Characteristics
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hikma Pharmaceuticals LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Frantz FANON

Blida, , Algeria

Site Status

Nedir Mohamed Hospital

Tizi Ouzou, , Algeria

Site Status

New University Hospital

Alexandria, , Egypt

Site Status

Demerdash hospital (Ain Shams University)

Cairo, , Egypt

Site Status

Private Clinic

Cairo, , Egypt

Site Status

King Abdullah University Hospital (KAUH)

Ar Ramtha, , Jordan

Site Status

Countries

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Algeria Egypt Jordan

Other Identifiers

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HIK-DMF-2020-01

Identifier Type: -

Identifier Source: org_study_id

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