Effect of Water Exchange Plus Acetic Acid Staining on the Detection of Flat Polyps During Colonoscopy
NCT ID: NCT04464135
Last Updated: 2020-07-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
300 participants
INTERVENTIONAL
2020-07-15
2021-05-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
SINGLE
Study Groups
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WE+AA group
Water containing 1% of AA was used during insertion of colonoscopy using water exchange method.
acetic acid staining
The water exchange colonoscopy is used during insertion procedure, in which the water contains 1% acetic acid, and the liquid is absorbed during the withdrawal process for observation.
WE group
Water exchange colonoscopy was used for standard screening or surveillance colonoscopy.
Water exchange colonoscopy
The water exchange colonoscopy is used during insertion procedure, and the liquid is absorbed during the withdrawal process for observation.
Interventions
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acetic acid staining
The water exchange colonoscopy is used during insertion procedure, in which the water contains 1% acetic acid, and the liquid is absorbed during the withdrawal process for observation.
Water exchange colonoscopy
The water exchange colonoscopy is used during insertion procedure, and the liquid is absorbed during the withdrawal process for observation.
Eligibility Criteria
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Inclusion Criteria
* Undergoing colonoscopy after standard bowel preparation
Exclusion Criteria
* Small amount of feces or semi-solid stool in last rectal effluent
* Inflammatory Bowel Disease
* Lactated or pregnant women
* Unable to provide informed content
40 Years
70 Years
ALL
No
Sponsors
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Air Force Military Medical University, China
OTHER
Responsible Party
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Yanglin Pan
Associated professor
Principal Investigators
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Yanglin Pan, MD
Role: PRINCIPAL_INVESTIGATOR
Xijing Hospital of Digestive Diseases
Locations
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Department of Gastroenterology, Second Affiliated Hospital, Lanzhou University
Lanzhou, Gansu, China
Department of Holistic Integrative Medicine, Shenzhen Hospital of Southern Medical University
Shenzhen, Guangdong, China
Department of Gastroenterology, Huaihe Hospital of Henan University
Kaifeng, Henan, China
Department of Gastroenterology, Shaanxi Second People's Hospital
Xi'an, Shaanxi, China
Countries
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Central Contacts
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Facility Contacts
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References
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Shibagaki K, Amano Y, Ishimura N, Yuki T, Taniguchi H, Fujita H, Kobayashi K, Kinoshita Y. Magnification endoscopy with acetic acid enhancement and a narrow-band imaging system for pit pattern diagnosis of colorectal neoplasms. J Clin Gastroenterol. 2015 Apr;49(4):306-12. doi: 10.1097/MCG.0000000000000148.
Jia H, Pan Y, Guo X, Zhao L, Wang X, Zhang L, Dong T, Luo H, Ge Z, Liu J, Hao J, Yao P, Zhang Y, Ren H, Zhou W, Guo Y, Zhang W, Chen X, Sun D, Yang X, Kang X, Liu N, Liu Z, Leung F, Wu K, Fan D. Water Exchange Method Significantly Improves Adenoma Detection Rate: A Multicenter, Randomized Controlled Trial. Am J Gastroenterol. 2017 Apr;112(4):568-576. doi: 10.1038/ajg.2016.501. Epub 2016 Dec 6.
Zhao S, Wang S, Pan P, Xia T, Chang X, Yang X, Guo L, Meng Q, Yang F, Qian W, Xu Z, Wang Y, Wang Z, Gu L, Wang R, Jia F, Yao J, Li Z, Bai Y. Magnitude, Risk Factors, and Factors Associated With Adenoma Miss Rate of Tandem Colonoscopy: A Systematic Review and Meta-analysis. Gastroenterology. 2019 May;156(6):1661-1674.e11. doi: 10.1053/j.gastro.2019.01.260. Epub 2019 Feb 6.
Desai M, Sanchez-Yague A, Choudhary A, Pervez A, Gupta N, Vennalaganti P, Vennelaganti S, Fugazza A, Repici A, Hassan C, Sharma P. Impact of cap-assisted colonoscopy on detection of proximal colon adenomas: systematic review and meta-analysis. Gastrointest Endosc. 2017 Aug;86(2):274-281.e3. doi: 10.1016/j.gie.2017.03.1524. Epub 2017 Mar 29.
Other Identifiers
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KY20200706-3
Identifier Type: -
Identifier Source: org_study_id
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