Targeting Sleep Homeostasis to Improve Alcohol Use Disorder Treatment Outcomes (M-STAR Study)

NCT ID: NCT04457674

Last Updated: 2025-07-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

131 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-15

Study Completion Date

2026-02-28

Brief Summary

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Insomnia is common in people who are in treatment for alcohol use disorder. It can impact both sleep quality and daytime functioning, as well as make it harder to treat the underlying alcohol use disorder. This study is looking at two types of therapy to help manage insomnia specifically for people also in treatment for alcohol use disorder.

Detailed Description

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Conditions

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Insomnia Alcohol Use Disorder

Keywords

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Cognitive Behavioral Therapy Sleep Hygiene

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Cognitive Behavioral Therapy for insomnia (CBTi)

CBTi is a non-medication therapy that includes cognitive and behavioral treatment components.

Group Type OTHER

Cognitive Behavioral Therapy for insomnia (CBTi)

Intervention Type BEHAVIORAL

CBTi consists of six weekly sessions of individual therapy with a trained therapist, delivered via telemedicine.

Sleep Hygiene Education (SHE)

SHE is a non-medication therapy that focuses on identifying and changing several behavioral and environmental factors that can interfere with sleep.

Group Type OTHER

Sleep Hygiene Education (SHE)

Intervention Type BEHAVIORAL

SHE participants receive six weekly sessions of individual therapy with a trained therapist, delivered via telemedicine.

Interventions

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Cognitive Behavioral Therapy for insomnia (CBTi)

CBTi consists of six weekly sessions of individual therapy with a trained therapist, delivered via telemedicine.

Intervention Type BEHAVIORAL

Sleep Hygiene Education (SHE)

SHE participants receive six weekly sessions of individual therapy with a trained therapist, delivered via telemedicine.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Meet probable Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria for Alcohol Use Disorder with ≤12 weeks of abstinence
* Planned enrollment into an abstinence-based treatment program
* Meet probable DSM-5 criteria for chronic insomnia, confirmed with sleep diary
* Ability to travel to Ann Arbor for sleep laboratory assessments
* Access to a video chat-capable device and reliable Wi-Fi network

Exclusion Criteria

* Diagnosis of, or high suspicion for, sleep disorders other than insomnia
* Meet probable DSM-5 criteria for bipolar disorder, psychotic disorder, or post-traumatic stress disorder (PTSD)
* Terminal or progressive physical illness (e.g., cancer), neurological degenerative disease (e.g., dementia), or presence of an unstable medical condition that is the specific cause of insomnia
* Self-reported pregnancy or intention to become pregnant during the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

Sponsor Role collaborator

University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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J. Todd Arnedt

Associate Professor of Psychiatry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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J Todd Arnedt, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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The University of Michigan

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Informed Consent Form

View Document

Other Identifiers

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R01AA028158

Identifier Type: NIH

Identifier Source: secondary_id

View Link

HUM00173631

Identifier Type: -

Identifier Source: org_study_id