Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss

NCT ID: NCT04455256

Last Updated: 2020-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-20

Study Completion Date

2020-07-07

Brief Summary

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To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress on recurrent pregnancy loss.

Detailed Description

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Conditions

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Recurrent Pregnancy Loss Endoplasmic Reticulum Stress

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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recurrent pregnancy loss group

Women between the ages of 18 and 45 who had a history of miscarriage under 3 weeks and above 22 weeks were included in this group.

x box binding protein

Intervention Type OTHER

Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

women who had healthy birth

Women between the ages of 18-45 who have not had a history of pregnancy loss and who have had at least one healthy birth and no known chronic diseases are included in this group.

x box binding protein

Intervention Type OTHER

Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

Interventions

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x box binding protein

Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* with three or more miscarriages before 20 th week of gestation
* had no chronic or acute inflammatory disease
* used no steroids, anti-inflammatory, or antioxidant medications

Exclusion Criteria

* had inflammatory diseases
* had systemic disease
* Anatomical abnormalities, infectious, endocrine, or genetic etiologies
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Kanuni Sultan Suleyman Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Pınar Yalcin bahat

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Pinar Yalcin Bahat

Istanbul, İ̇stanbul, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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tgk-xbp

Identifier Type: -

Identifier Source: org_study_id

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