Early Diagnosis of Compartment Syndrome by Multimodal Detection Technique
NCT ID: NCT04442672
Last Updated: 2020-06-22
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
25 participants
Study Classification
INTERVENTIONAL
Study Start Date
2019-05-01
Study Completion Date
2019-08-10
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
compartment syndrome has a high incidence in patients with a variety of diseases, including fractures, and delayed diagnosis or without intervention can lead to severe adverse prognosis, such as limb deformities, amputations and even death. Early diagnosis and early intervention are important, especially early diagnosis. Now, the diagnosis of compartment syndrome in clinical is based on medical history, clinical manifestations and measuring the compartment pressure by fine needle puncture. However, this diagnostic method is not easy to achieve early accurate diagnosis and non-invasive continuous monitoring. The study found that the increase of compartment pressure can lead to local changes of hemodynamic, tissue metabolism and nerve function. There are also studies and reports of near-infrared spectral tissue oxygen measurement technology, ultrasonic Doppler technology, near-infrared spectral pulse oxygen measurement technology and infrared thermal imaging technology can be used for noninvasive monitoring of acute compartment syndrome, but it is not clear that which is better above in early diagnosis of acute compartment syndrome.
The purpose of this study was to simulate the process of early pressure increase in the compartment by pressurizing the volunteers' calves by cuff, and then measured the tissue oxygen in the Anterior fascia compartment using a non-invasive monitor of the tissue oxygen parameters, the ultrasonic machine measured the blood flow signal of the upper and lower backbone blood vessels, and the blood oxygen meter to measure the blood saturation of the upper and lower ends of the limb. The infrared thermal imager measured the near and far limb temperature of the hemostatic belt and the two-point identification of the skin sensory nerve function at the far end of the fascia chamber. Then compare the correlation of these indicators with pressure changes.
The purpose of this study was to simulate the process of early pressure increase in the compartment by pressurizing the volunteers' calves by cuff, and then measured the tissue oxygen in the Anterior fascia compartment using a non-invasive monitor of the tissue oxygen parameters, the ultrasonic machine measured the blood flow signal of the upper and lower backbone blood vessels, and the blood oxygen meter to measure the blood saturation of the upper and lower ends of the limb. The infrared thermal imager measured the near and far limb temperature of the hemostatic belt and the two-point identification of the skin sensory nerve function at the far end of the fascia chamber. Then compare the correlation of these indicators with pressure changes.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Continuous Pressure Monitoring In Lower Leg Fractures
NCT00358514
Compartment Syndrome
TERMINATED
NA
Biomarkers in the Diagnosis of Acute Compartment Syndrome
NCT04674592
Acute Compartment Syndrome
Tibia Fracture
UNKNOWN
Natural History of Anterior Compartment Pressures of the Thigh Following Femur Fracture
NCT00919464
Femur Fracture
TERMINATED
NA
Assessement of Vertebroplasty-related Cement Leakage
NCT04867577
Vertebral Fracture
UNKNOWN
Compartmental Overpressures Associated to Reamed Intramedullary Nails
NCT00842101
Tibial Fractures
COMPLETED
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
The participants is health volunteers, age 18-60 years. When the participants agree to participate in the experiment, the experimenter first needs to explain the experimental process to the participants, and ask the participants to agree and sign the informed consent before they can conduct the experiment. The experiment was conducted in the emergency medicine department of a university-affiliated top three hospital.
When the participants are included in the experimental study, the general demographic information of the participants, such as name, gender, age, etc., is first collected. Ensure the experimental environment is comfortable, ambient temperature 20-24℃, ambient humidity 50-60%. Participants have loose clothing on their lower limbs to avoid pressure on their limbs. Take the supine position, keep the calf hanging, support the heel, make the calf level flush with the heart, rest for 5 minutes.
The monitor (M3002A, Philips Medizin Systeme Boeblingen GmbH, Germany) was used to continuously monitor the electrocardiogram, the left upper arm measured blood pressure (BP), and the right middle finger to monitor pulse oximetry (SpO2). The calf circumference was measured at the midpoint of the bilateral humerus with a soft ruler. The maximum thickness of anterior fascia compartment was measured at the midpoint of the tibia using an ultrasonic machine (Acclarix AX8, Shenzhen Libang Precision Instrument Co., Ltd., China).
The random number table method selects one side of the calf as the experimental side and the opposite side as the control side.
(8) The following parameters were recorded at baseline (pressure 0mmHg in the calf tourniquet on both sides): (1) heart rate, blood pressure; (2) right middle finger, lower limbs, middle toe finger vein oxygen SpO2; (3) bilateral Local blood tissue parameters (TOI, THI, ΔCHb, CHbO2, ΔCtHb) in the calf; (4) Near-infrared thermography temperature values (T-u1, T-u2) in the knee and thighs of the lower leg and the instep and toe Near-infrared thermography temperature values (T-d1, T-d2); (5) bilateral radial artery ultrasound Doppler measurement parameters (D-pa, S-pa, Vs-pa, Vd-pa, DRAF-pa) Ultrasound Doppler measurement parameters of bilateral iliac veins (D-pv, S-pv, Vs-pv, Vd-pv), bilateral posterior tibial artery and dorsal artery ultrasound Doppler measurement parameters (Vs-pta, Vd -pta, SFAF-pta, Vs-da, Vd-da, SFAF-da). (6) Two-point identification threshold TPD.
In turn, the experimental side calf tourniquet was inflated and pressurized to a pressure value of 20, 30, 40, 50, 60, 70, 80 mmHg, and the pressure inside the tourniquet was up to 10 s during pressurization, and maintained stable for 1 min, measured and the above indicators were recorded within 3 min. During the experiment, the subjects were closely monitored for adverse reactions. At the end of the study, the observation was continued for 30 minutes, and the drinking water was at least 500 ml, and the limb sensation, pain and urine color were continuously observed within 24 hours.
When the participants are included in the experimental study, the general demographic information of the participants, such as name, gender, age, etc., is first collected. Ensure the experimental environment is comfortable, ambient temperature 20-24℃, ambient humidity 50-60%. Participants have loose clothing on their lower limbs to avoid pressure on their limbs. Take the supine position, keep the calf hanging, support the heel, make the calf level flush with the heart, rest for 5 minutes.
The monitor (M3002A, Philips Medizin Systeme Boeblingen GmbH, Germany) was used to continuously monitor the electrocardiogram, the left upper arm measured blood pressure (BP), and the right middle finger to monitor pulse oximetry (SpO2). The calf circumference was measured at the midpoint of the bilateral humerus with a soft ruler. The maximum thickness of anterior fascia compartment was measured at the midpoint of the tibia using an ultrasonic machine (Acclarix AX8, Shenzhen Libang Precision Instrument Co., Ltd., China).
The random number table method selects one side of the calf as the experimental side and the opposite side as the control side.
(8) The following parameters were recorded at baseline (pressure 0mmHg in the calf tourniquet on both sides): (1) heart rate, blood pressure; (2) right middle finger, lower limbs, middle toe finger vein oxygen SpO2; (3) bilateral Local blood tissue parameters (TOI, THI, ΔCHb, CHbO2, ΔCtHb) in the calf; (4) Near-infrared thermography temperature values (T-u1, T-u2) in the knee and thighs of the lower leg and the instep and toe Near-infrared thermography temperature values (T-d1, T-d2); (5) bilateral radial artery ultrasound Doppler measurement parameters (D-pa, S-pa, Vs-pa, Vd-pa, DRAF-pa) Ultrasound Doppler measurement parameters of bilateral iliac veins (D-pv, S-pv, Vs-pv, Vd-pv), bilateral posterior tibial artery and dorsal artery ultrasound Doppler measurement parameters (Vs-pta, Vd -pta, SFAF-pta, Vs-da, Vd-da, SFAF-da). (6) Two-point identification threshold TPD.
In turn, the experimental side calf tourniquet was inflated and pressurized to a pressure value of 20, 30, 40, 50, 60, 70, 80 mmHg, and the pressure inside the tourniquet was up to 10 s during pressurization, and maintained stable for 1 min, measured and the above indicators were recorded within 3 min. During the experiment, the subjects were closely monitored for adverse reactions. At the end of the study, the observation was continued for 30 minutes, and the drinking water was at least 500 ml, and the limb sensation, pain and urine color were continuously observed within 24 hours.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Compartment Syndrome of Leg
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
DIAGNOSTIC
Blinding Strategy
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
compartment syndrome model group(CSM group)
Group Type
EXPERIMENTAL
acute compartment syndrome model of health volunteer
Intervention Type
PROCEDURE
the acute compartment syndrome model of health volunteer is induced by pressurizing the calves by the cuff, and the cuff is inflated and pressurized to a pressure value of 20, 30, 40, 50, 60, 70, 80 mmHg. the pressure inside the cuff was up to 10 s during pressurization and maintained stable for 1 min, measured and the above indicators were recorded within 3 min.
sham group
Group Type
SHAM_COMPARATOR
sham
Intervention Type
PROCEDURE
surrounding the cuff but not inflate it.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
acute compartment syndrome model of health volunteer
the acute compartment syndrome model of health volunteer is induced by pressurizing the calves by the cuff, and the cuff is inflated and pressurized to a pressure value of 20, 30, 40, 50, 60, 70, 80 mmHg. the pressure inside the cuff was up to 10 s during pressurization and maintained stable for 1 min, measured and the above indicators were recorded within 3 min.
Intervention Type
PROCEDURE
sham
surrounding the cuff but not inflate it.
Intervention Type
PROCEDURE
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Healthy adults, aged 18-60 years; No obvious cardiovascular diseases such as cardiovascular and cerebrovascular diseases; Complete limbs without deformity and no history of lower limb trauma; Informed consent
Exclusion Criteria
* pregnancy or use of oral contraceptives; History of diabetes; History of deep vein thrombosis; Peripheral neuropathy; peripheral vascular disease; History of rhabdomyolysis
Minimum Eligible Age
18 Years
Maximum Eligible Age
60 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Second Affiliated Hospital, School of Medicine, Zhejiang University
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Responsibility Role
SPONSOR
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Mao Zhang, PHD
Role: STUDY_CHAIR
Second Affiliated Hospital, School of Medicine, Zhejiang University
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
2nd Affiliated Hospital, Zhejiang University School of Medicine Institute of Emergency Medicine, Zhejiang University
Hanzhou, Zhejiang, China
Site Status
Countries
Review the countries where the study has at least one active or historical site.
China
References
Explore related publications, articles, or registry entries linked to this study.
Shadgan B, Pereira G, Menon M, Jafari S, Darlene Reid W, O'Brien PJ. Risk factors for acute compartment syndrome of the leg associated with tibial diaphyseal fractures in adults. J Orthop Traumatol. 2015 Sep;16(3):185-92. doi: 10.1007/s10195-014-0330-y. Epub 2014 Dec 28.
Reference Type
BACKGROUND
Olson SA, Glasgow RR. Acute compartment syndrome in lower extremity musculoskeletal trauma. J Am Acad Orthop Surg. 2005 Nov;13(7):436-44. doi: 10.5435/00124635-200511000-00003.
Reference Type
BACKGROUND
McQueen MM, Duckworth AD. The diagnosis of acute compartment syndrome: a review. Eur J Trauma Emerg Surg. 2014 Oct;40(5):521-8. doi: 10.1007/s00068-014-0414-7. Epub 2014 Jun 3.
Reference Type
BACKGROUND
Mubarak SJ, Hargens AR. Acute compartment syndromes. Surg Clin North Am. 1983 Jun;63(3):539-65. doi: 10.1016/s0039-6109(16)43030-6. No abstract available.
Reference Type
BACKGROUND
von Keudell AG, Weaver MJ, Appleton PT, Bae DS, Dyer GSM, Heng M, Jupiter JB, Vrahas MS. Diagnosis and treatment of acute extremity compartment syndrome. Lancet. 2015 Sep 26;386(10000):1299-1310. doi: 10.1016/S0140-6736(15)00277-9.
Reference Type
BACKGROUND
Shadgan B, Menon M, Sanders D, Berry G, Martin C Jr, Duffy P, Stephen D, O'Brien PJ. Current thinking about acute compartment syndrome of the lower extremity. Can J Surg. 2010 Oct;53(5):329-34.
Reference Type
BACKGROUND
Soller BR, Yang Y, Soyemi OO, Ryan KL, Rickards CA, Walz JM, Heard SO, Convertino VA. Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans. J Appl Physiol (1985). 2008 Feb;104(2):475-81. doi: 10.1152/japplphysiol.00600.2007. Epub 2007 Nov 15.
Reference Type
BACKGROUND
Mancini DM, Bolinger L, Li H, Kendrick K, Chance B, Wilson JR. Validation of near-infrared spectroscopy in humans. J Appl Physiol (1985). 1994 Dec;77(6):2740-7. doi: 10.1152/jappl.1994.77.6.2740.
Reference Type
RESULT
Shuler MS, Reisman WM, Kinsey TL, Whitesides TE Jr, Hammerberg EM, Davila MG, Moore TJ. Correlation between muscle oxygenation and compartment pressures in acute compartment syndrome of the leg. J Bone Joint Surg Am. 2010 Apr;92(4):863-70. doi: 10.2106/JBJS.I.00816.
Reference Type
RESULT
Breit GA, Gross JH, Watenpaugh DE, Chance B, Hargens AR. Near-infrared spectroscopy for monitoring of tissue oxygenation of exercising skeletal muscle in a chronic compartment syndrome model. J Bone Joint Surg Am. 1997 Jun;79(6):838-43. doi: 10.2106/00004623-199706000-00006.
Reference Type
RESULT
Cathcart CC, Shuler MS, Freedman BA, Reno LR, Budsberg SC. Correlation of near-infrared spectroscopy and direct pressure monitoring in an acute porcine compartmental syndrome model. J Orthop Trauma. 2014 Jun;28(6):365-9. doi: 10.1097/BOT.0b013e3182a75ceb.
Reference Type
RESULT
Gentilello LM, Sanzone A, Wang L, Liu PY, Robinson L. Near-infrared spectroscopy versus compartment pressure for the diagnosis of lower extremity compartmental syndrome using electromyography-determined measurements of neuromuscular function. J Trauma. 2001 Jul;51(1):1-8, discussion 8-9. doi: 10.1097/00005373-200107000-00001.
Reference Type
RESULT
Arbabi S, Brundage SI, Gentilello LM. Near-infrared spectroscopy: a potential method for continuous, transcutaneous monitoring for compartmental syndrome in critically injured patients. J Trauma. 1999 Nov;47(5):829-33. doi: 10.1097/00005373-199911000-00002.
Reference Type
RESULT
Schmidt AH, Bosse MJ, Obremskey WT, O'Toole RV, Carroll EA, Stinner DJ, Hak DJ, Karunakar M, Hayda R, Frey KP, Di J, Zipunnikov V, MacKenzie E; Major Extremity Trauma Research Consortium (METRC). Continuous Near-Infrared Spectroscopy Demonstrates Limitations in Monitoring the Development of Acute Compartment Syndrome in Patients with Leg Injuries. J Bone Joint Surg Am. 2018 Oct 3;100(19):1645-1652. doi: 10.2106/JBJS.17.01495.
Reference Type
RESULT
Garr JL, Gentilello LM, Cole PA, Mock CN, Matsen FA 3rd. Monitoring for compartmental syndrome using near-infrared spectroscopy: a noninvasive, continuous, transcutaneous monitoring technique. J Trauma. 1999 Apr;46(4):613-6; discussion 617-8. doi: 10.1097/00005373-199904000-00009.
Reference Type
RESULT
Lima A, Bakker J. Near-infrared spectroscopy for monitoring peripheral tissue perfusion in critically ill patients. Rev Bras Ter Intensiva. 2011 Sep;23(3):341-51. English, Portuguese.
Reference Type
RESULT
Boezeman RP, Becx BP, van den Heuvel DA, Unlu C, Vos JA, de Vries JP. Monitoring of Foot Oxygenation with Near-infrared Spectroscopy in Patients with Critical Limb Ischemia Undergoing Percutaneous Transluminal Angioplasty: A Pilot Study. Eur J Vasc Endovasc Surg. 2016 Nov;52(5):650-656. doi: 10.1016/j.ejvs.2016.07.020. Epub 2016 Sep 7.
Reference Type
RESULT
Feldman F, Nickoloff EL. Normal thermographic standards for the cervical spine and upper extremities. Skeletal Radiol. 1984;12(4):235-49. doi: 10.1007/BF00349505.
Reference Type
RESULT
Uematsu S, Edwin DH, Jankel WR, Kozikowski J, Trattner M. Quantification of thermal asymmetry. Part 1: Normal values and reproducibility. J Neurosurg. 1988 Oct;69(4):552-5. doi: 10.3171/jns.1988.69.4.0552.
Reference Type
RESULT
Thangam S, Vaz M, Kurpad AV, Shetty PS. Superficial thermal gradients during mild body cooling and its relationship to forearm blood flow. Indian J Physiol Pharmacol. 1993 Oct;37(4):328-32.
Reference Type
RESULT
Katz LM, Nauriyal V, Nagaraj S, Finch A, Pearlstein K, Szymanowski A, Sproule C, Rich PB, Guenther BD, Pearlstein RD. Infrared imaging of trauma patients for detection of acute compartment syndrome of the leg. Crit Care Med. 2008 Jun;36(6):1756-61. doi: 10.1097/CCM.0b013e318174d800.
Reference Type
RESULT
Theuma F, Cassar K. The use of smartphone-attached thermography camera in diagnosis of acute lower limb ischemia. J Vasc Surg. 2018 Apr;67(4):1297. doi: 10.1016/j.jvs.2017.02.054. No abstract available.
Reference Type
RESULT
Lin PH, Saines M. Assessment of lower extremity ischemia using smartphone thermographic imaging. J Vasc Surg Cases Innov Tech. 2017 Oct 14;3(4):205-208. doi: 10.1016/j.jvscit.2016.10.012. eCollection 2017 Dec.
Reference Type
RESULT
Turnipseed WD, Hurschler C, Vanderby R Jr. The effects of elevated compartment pressure on tibial arteriovenous flow and relationship of mechanical and biochemical characteristics of fascia to genesis of chronic anterior compartment syndrome. J Vasc Surg. 1995 May;21(5):810-6; discussion 816-7. doi: 10.1016/s0741-5214(05)80012-6.
Reference Type
RESULT
Wiebe S, Kellenberger CJ, Khoury A, Miller SF. Early Doppler changes in a renal transplant patient secondary to abdominal compartment syndrome. Pediatr Radiol. 2004 May;34(5):432-4. doi: 10.1007/s00247-003-1094-3. Epub 2003 Dec 17.
Reference Type
RESULT
Kirkpatrick AW, Colistro R, Laupland KB, Fox DL, Konkin DE, Kock V, Mayo JR, Nicolaou S. Renal arterial resistive index response to intraabdominal hypertension in a porcine model. Crit Care Med. 2007 Jan;35(1):207-13. doi: 10.1097/01.CCM.0000249824.48222.B7.
Reference Type
RESULT
Auerbach DN, Bowen AD 3rd. Sonography of leg in posterior compartment syndrome. AJR Am J Roentgenol. 1981 Feb;136(2):407-8. doi: 10.2214/ajr.136.2.407. No abstract available.
Reference Type
RESULT
Mc Loughlin S, Mc Loughlin MJ, Mateu F. Pulsed Doppler in simulated compartment syndrome: a pilot study to record hemodynamic compromise. Ochsner J. 2013 Winter;13(4):500-6.
Reference Type
RESULT
Rosales-Velderrain A, Padilla M, Choe CH, Hargens AR. Increased microvascular flow and foot sensation with mild continuous external compression. Physiol Rep. 2013 Dec 19;1(7):e00157. doi: 10.1002/phy2.157. eCollection 2013 Dec 1.
Reference Type
RESULT
Clayton JM, Hayes AC, Barnes RW. Tissue pressure and perfusion in the compartment syndrome. J Surg Res. 1977 Apr;22(4):333-9. doi: 10.1016/0022-4804(77)90152-4. No abstract available.
Reference Type
RESULT
Lynch JE, Lynch JK, Cole SL, Carter JA, Hargens AR. Noninvasive monitoring of elevated intramuscular pressure in a model compartment syndrome via quantitative fascial motion. J Orthop Res. 2009 Apr;27(4):489-94. doi: 10.1002/jor.20778.
Reference Type
RESULT
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
I2019001099
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Construction of the Evaluation System of Limb Blood Circulation After Fracture of Limbs in Children
NCT03700216
UNKNOWN
Relationship Between Mortality Rates of Fractures in Different Sites and Several Factors in Elderly Patients
NCT07147504
NOT_YET_RECRUITING
The Mobility Toolkit: Electronically Augmented Assessment of Functional Recovery Following Lower-extremity Trauma
NCT04047030
COMPLETED
Postoperative Computed Tomography Detection of Syndesmotic Malreduction in Ankle Fractures
NCT07338149
COMPLETED
4 Dimensional - Impairment of Posttraumatic Forearm Rotation Evaluated With Computed Tomography
NCT04067232
COMPLETED
NA
Clinical Applications of a Joystick in Femoral Shaft Fractures
NCT03417310
COMPLETED
NA
The Role of NM/CT 870 DR Camera in the Diagnosis of Joint Prosthesis and Tibial Open Reduction and Internal Fixation (ORIF) Complications.
NCT04154202
UNKNOWN
NA
Freeze-dried Bovine Hydroxyapatite/Secretome Composite for Bone Defects
NCT04980261
UNKNOWN
NA
Classification of Ankle Injury Observed With X-ray Combined With Magnetic Resonance Imaging
NCT02971943
COMPLETED
NA
Diagnosing Extremity Fractures and/or Dislocations Using Ultrasound Presenting to the Emergency Department
NCT00356837
TERMINATED
NA
Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone
NCT02544386
TERMINATED
Comparison Different Method Treatment in Tuberosity Fractures of the Proximal Fifth Metatarsal
NCT04168411
COMPLETED
NA
A Retrospective Study on the Outcome of Different Fixation Methods After Olecranon Osteotomy
NCT04376801
UNKNOWN
Digital Three-dimensional Imaging Models for Repair of Complex Long Bone Fractures
NCT02964754
COMPLETED
NA
Subsidence of Cementless Stem Following Arthroplasty for Fracture Neck of Femur
NCT05670717
UNKNOWN
Minimally Invasive of Proximal Humerus Fractures With Internal Fixation Improves Shoulder Function in Older Patients
NCT02784522
COMPLETED
NA
Surgical Management of Posterior Malleolar Fractures Using the Direct or Indirect Reduction Techniques
NCT02801474
COMPLETED
NA
Hip Fracture and Muscle Resilience
NCT04167020
COMPLETED
Early Range of Motion in 5th Metacarpal Fracture
NCT02441790
WITHDRAWN
NA
Fluoroscopy vs. Computed Tomography for Diagnosis of Displacement and Instability of Acute Scaphoid Waist Fractures
NCT02479009
WITHDRAWN
NA
Controlling Femoral Derotation Osteotomy With Electromagnetic Tracking
NCT02976532
UNKNOWN
NA
Characterization of Residual Limb Volume Changes in Transfemoral Amputees
NCT04709367
COMPLETED
Locking Plates for Distal Femur Fractures - a Multicenter Case Review
NCT04008940
COMPLETED
Peroneal Nerve Dysfunction in Epiphyseal Transfer
NCT05884827
RECRUITING