Real World Study of Regorafenib Versus Fruquintinib in Colorectal Cancer

NCT ID: NCT04431791

Last Updated: 2020-06-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

268 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-05-25

Study Completion Date

2022-02-01

Brief Summary

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This is an observational, ambispective cohort study. The aim is to compare the efficacy and safety of regorafenib versus fruquintinib conducted in China. About 268 eligible metastatic colorectal cancer patients after second-line therapy will be assigned to receive either regorafenib or fruquintinib, based on decision of the gastrointestinal physician according the patients' condition.

Detailed Description

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Conditions

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Colorectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Regorafenib

Regorafenib

Intervention Type DRUG

oral regorafenib

Fruquintinib

Fruquintinib

Intervention Type DRUG

oral fruquintinib

Interventions

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Regorafenib

oral regorafenib

Intervention Type DRUG

Fruquintinib

oral fruquintinib

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. signed and dated informed consent.
2. Diagnosis of histologically confirmed colorectal cancer, stage IV.
3. after second-line therapy.
4. gastrointestinal physician prescribed to receive regorafenib or fruquintinib according the patients' condition.

Exclusion Criteria

1. received regorafenib or fruquintinib before third-line therapy.
2. the clinicopathological characteristics and previous therapy were unknown.
3. regorafenib or fruquintinib treatment is less than one cycle in the historical cohort.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University

OTHER

Sponsor Role lead

Responsible Party

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Shen Lin

MD, Professor, Chief of Department of GI Oncology, Peking University Cancer Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Beijing Cancer Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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Jian Li, MD

Role: primary

86-010-88196088

Other Identifiers

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Reg vs Fru

Identifier Type: -

Identifier Source: org_study_id

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