Oleocanthal Rich Olive Oil Acute Effects on Hyperglycemia and Platelet Activation in T2DM
NCT ID: NCT04419948
Last Updated: 2020-06-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
15 participants
INTERVENTIONAL
2019-05-16
2021-07-31
Brief Summary
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Taking into account the strong anti-inflammatory and anti-platelet properties of oleocanthal, this study will assess whether oleocanthal-rich olive oils could exert similar effects under real in vivo conditions in T2DM patients. It will also assess whether these effects are achieved through improvement of postprandial glycemia and lipemia.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
SINGLE
Study Groups
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Control
100g white bread plus 40ml butter
White bread
White bread (120g) containing 54 g CHO
Butter
Butter 39 g
Positive control
100g white bread plus 40ml butter and 400mg ibuprofen
White bread
White bread (120g) containing 54 g CHO
Butter
Butter 39 g
Ibuprofen
Ibuprofen 400 mg
Refined olive oil
100g white bread plus 40ml refined olive oil
White bread
White bread (120g) containing 54 g CHO
Refined olive oil
Refined olive oil (40 ml).
EVOO with moderate concentration of oleocanthal
100g white bread plus 40ml EVOO containing 250 mg/kg oleocanthal
White bread
White bread (120g) containing 54 g CHO
EVOO with 250 mg/kg oleocanthal
Extra virgin olive oil containing 250 mg/kg oleocanthal.
EVOO with high concentration of oleocanthal
100g white bread plus 40ml EVOO containing 500 mg/kg oleocanthal
White bread
White bread (120g) containing 54 g CHO
EVOO with 500 mg/kg oleocanthal
Extra virgin olive oil containing 500 mg/kg oleocanthal.
Interventions
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White bread
White bread (120g) containing 54 g CHO
Butter
Butter 39 g
Refined olive oil
Refined olive oil (40 ml).
EVOO with 250 mg/kg oleocanthal
Extra virgin olive oil containing 250 mg/kg oleocanthal.
EVOO with 500 mg/kg oleocanthal
Extra virgin olive oil containing 500 mg/kg oleocanthal.
Ibuprofen
Ibuprofen 400 mg
Eligibility Criteria
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Inclusion Criteria
* stable weight the last two months
* smokers or not
* no restriction regarding the menopause
Exclusion Criteria
* antiplatelet, anti-coagulant, anti-inflammatory and anti-depressant medication
* chronic inflammatory disease
* autoimmune diseases
* cancer
* uncontrolled thyroid disease.
* supplement consumption the last two months
18 Years
ALL
No
Sponsors
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National and Kapodistrian University of Athens
OTHER
University of Peloponnese
OTHER
Harokopio University
OTHER
Responsible Party
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Tzortzis Nomikos
Assistant Professor of Biochemistry
Locations
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Department of Nutrition and Dietetics, Harokopio University
Athens, I Am Not in the U.S. Or Canada, Greece
Countries
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Central Contacts
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Facility Contacts
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References
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Agrawal K, Melliou E, Li X, Pedersen TL, Wang SC, Magiatis P, Newman JW, Holt RR. Oleocanthal-rich extra virgin olive oil demonstrates acute anti-platelet effects in healthy men in a randomized trial. J Funct Foods. 2017 Sep;36:84-93. doi: 10.1016/j.jff.2017.06.046. Epub 2017 Jul 3.
Other Identifiers
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79549/16-05-2019
Identifier Type: -
Identifier Source: org_study_id
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