Long-term Outcome After Gestational Diabetes and Diabetes in Pregnancy

NCT ID: NCT04417452

Last Updated: 2023-04-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-09-01

Study Completion Date

2023-12-31

Brief Summary

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The primary objectives of the proposed project are to assess the long-term effects of prenatal exposure to gestational diabetes or diabetes on the maturation and health of the offspring. In addition, the long-term changes on the health of the affected mothers will be investigated, taking into account the metabolic adjustment during index pregnancy. The expected results will help to establish possible prevention strategies to fight the epidemic of non-communicable diseases for the offspring and the mothers.

Detailed Description

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Investigation of the long-term outcome of mother-child pairs after diabetic pregnancies and a comparison group regarding metabolic, cardiovascular, neurocognitive and reproductive long-term changes as a function of the course of pregnancy and metabolic control

Conditions

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Diabetes, Gestational Pregnancy Diabetic

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Mothers / children after diabetes in pregnancy

The study collective is composed of mother-child pairs after gestational diabetes, which were supervised in the Competence Center for Diabetes and Pregnancy at the University Hospital of Jena. The patients can decide to fill in an online questionnaire. For all other parts of the study, only patients who have been informed individually or on behalf of their legal guardian about the nature of the study after a detailed and understandable explanatory discussion with an investigator and who have given written consent will be included in the study.

Basic data collection (online survey or written form)

Intervention Type OTHER

Basic data collection is carried out by means of a questionnaire that participants can fill in outside the study centre. It contains questions about the current life situation, sleep and activity behaviour.

Physical examination

Intervention Type OTHER

The physical examination takes place at the study centre and includes the measurement of height, current weight and body fat, as well as the recording of heart and circulation parameters (e.g. blood pressure measurement or determination of vascular health by means of ultrasound). General metabolic and hormonal parameters are analysed by means of a blood sample. In addition, a sugar test for diabetes diagnosis will be carried out.

Psychometric examination

Intervention Type BEHAVIORAL

Psychometric examination is carried out at the study centre with the help of a RIAS (Reynolds Intellectual Assessment Scales and Screening) test.

Recording of the adrenergic stress reaction (saliva test)

Intervention Type DIAGNOSTIC_TEST

The adrenergic stress reaction is recorded by a saliva test.

Controls

The control collective is composed of mother-child pairs who were cared for at the same time as the study collective at the University Hospital Jena. This collective is status post singleton pregnancy and term birth. The patients can decide to fill in an online questionnaire. For all other parts of the study, only patients who have been informed individually or on behalf of their legal guardian about the nature of the study after a detailed and understandable explanatory discussion with an investigator and who have given written consent will be included in the study.

Basic data collection (online survey or written form)

Intervention Type OTHER

Basic data collection is carried out by means of a questionnaire that participants can fill in outside the study centre. It contains questions about the current life situation, sleep and activity behaviour.

Physical examination

Intervention Type OTHER

The physical examination takes place at the study centre and includes the measurement of height, current weight and body fat, as well as the recording of heart and circulation parameters (e.g. blood pressure measurement or determination of vascular health by means of ultrasound). General metabolic and hormonal parameters are analysed by means of a blood sample. In addition, a sugar test for diabetes diagnosis will be carried out.

Psychometric examination

Intervention Type BEHAVIORAL

Psychometric examination is carried out at the study centre with the help of a RIAS (Reynolds Intellectual Assessment Scales and Screening) test.

Recording of the adrenergic stress reaction (saliva test)

Intervention Type DIAGNOSTIC_TEST

The adrenergic stress reaction is recorded by a saliva test.

Interventions

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Basic data collection (online survey or written form)

Basic data collection is carried out by means of a questionnaire that participants can fill in outside the study centre. It contains questions about the current life situation, sleep and activity behaviour.

Intervention Type OTHER

Physical examination

The physical examination takes place at the study centre and includes the measurement of height, current weight and body fat, as well as the recording of heart and circulation parameters (e.g. blood pressure measurement or determination of vascular health by means of ultrasound). General metabolic and hormonal parameters are analysed by means of a blood sample. In addition, a sugar test for diabetes diagnosis will be carried out.

Intervention Type OTHER

Psychometric examination

Psychometric examination is carried out at the study centre with the help of a RIAS (Reynolds Intellectual Assessment Scales and Screening) test.

Intervention Type BEHAVIORAL

Recording of the adrenergic stress reaction (saliva test)

The adrenergic stress reaction is recorded by a saliva test.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* For the pilot project: Initial participation in the preliminary study
* Written Informed Consent
* Singleton pregnancies
* Delivery at the University Hospital Jena

Exclusion Criteria

* Severe physical and mental illness
* Patients who refuse to participate in the study or drop out
* Premature birth, i.e. birth of the child \<37/0 weeks of gestation
* Serious pregnancy complications
* Prenatally known serious malformations
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jena University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Friederike Weschenfelder, Dr. med.

Role: PRINCIPAL_INVESTIGATOR

Klinik für Geburtsmedizin

Locations

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Universitätsklinikum Jena

Jena, Thuringia, Germany

Site Status

Countries

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Germany

Other Identifiers

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2019-1403

Identifier Type: -

Identifier Source: org_study_id

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