Validation of the Italian Version of the PRO-CTCAE

NCT ID: NCT04416672

Last Updated: 2023-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

3675 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-07-01

Study Completion Date

2024-07-31

Brief Summary

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The aim of this study is to complete the validation process by testing the remaining two psychometric properties (validity and responsiveness) of the Italian version of the PRO-CTCAE in a large group of patients. In particular, for the first time this study will validate the tool for individual types of cancer and will provide information on psychometric properties based on the type of treatment used in clinical practice.

Detailed Description

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This is a prospective observational study, conducted in Italian cancer centers located Nationwide.

The investigators plan to consider for validation 21tumor sites, which correspond to the conditions for which a specific EORTC module has been produced, plus all remaining cancer types classified as "other setting".

The study will take place during two planned visits, one the first the day of enrollment, the second after 3-6 weeks. Enrolled patients will be asked to complete a subset of the PRO-CTCAE items based on cancer type, and the following instruments used as anchors to measure psychometric properties:

* EORTC Quality of Life disease-specific module, if a linguistically validated Italian version exists, or the General QLQ-C30, if the Italian version is not available.
* the Hospital Anxiety and Depression Scale (HADS)
* The Patients' Global Impression of Change (PGIC) Scale

Conditions

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Malignant Neoplasms

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

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PRO-CTCAE items

Enrolled patients will be asked to complete a subset of the PRO-CTCAE items based on cancer type, and the following instruments used as anchors to measure psychometric properties:

* the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life disease-specific module, if a linguistically validated Italian version exists, or the General QLQ-C30, if the Italian version is not available.
* the Hospital Anxiety and Depression Scale (HADS)
* The Patients' Global Impression of Change (PGIC) Scale.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of any type of cancer

•≥18 years of age.
* Female or male
* With at least two planned clinic visits (a return visit within 3-6 weeks) to avoid the need of extra visits
* Actively receiving treatment for cancer (going to receive the second or further cycle)
* Any ECOG performance status (PS)
* Able to complete questionnaire by themselves or with assistance, by using a tablet
* Able to speak and understand Italian
* Providing informed written consent

Exclusion Criteria

* Having any kind of psychiatric disorder or major cognitive dysfunction hampering the provision of informed consent.
* Having received more than 5lines of therapies
* Currently participating in other trials which imply the completion of Patient Reported Outcomes (PROs) in the same period
* Other important acute medical conditions.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute, Naples

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Francesco Perrone, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale

Locations

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Oncologia Medica per la Patologia Toracica- IRCCS Giovanni Paolo II

Bari, , Italy

Site Status RECRUITING

U.O.C. Oncologia Medica - Ospedale Senatore Antonio Perrino

Brindisi, , Italy

Site Status RECRUITING

Azienda Ospedaliero Universitaria di Cagliar

Cagliari, , Italy

Site Status RECRUITING

Oncologia Medica 2 - IRCCS AOU San Martino

Genova, , Italy

Site Status RECRUITING

Oncologia - A.O. Cardinale G. Panico

Lecce, , Italy

Site Status RECRUITING

Oncologia Medica - AO Vito Fazzi

Lecce, , Italy

Site Status RECRUITING

Oncologia Medica, Istituto Romagnolo per lo Studio e la Cura dei Tumori

Meldola, , Italy

Site Status RECRUITING

A.O.Ospedali Riuniti Papardo Piemonte U.O.C. di Oncologia Medica

Messina, , Italy

Site Status RECRUITING

Fondazione IRCCS, Istituto Nazionale dei Tumori

Milan, , Italy

Site Status RECRUITING

Ginecologia e Ostetricia - IRCCS Ospedale San Raffaele

Milan, , Italy

Site Status RECRUITING

Oncologia - ASST Rhodense - Presidio di Garbagnat

Milan, , Italy

Site Status RECRUITING

Oncologia - ASST Rhodense - Presidio di Rho

Milan, , Italy

Site Status RECRUITING

Istituto Nazionale Tumori, Dip. Uro-Ginecologico S.C. Oncologia Clinica Sperimentale Uro-Ginecologica

Naples, , Italy

Site Status RECRUITING

Oncologia Medica Toraco-Polmonare -Istituto Nazionale Tumori

Naples, , Italy

Site Status RECRUITING

Servizio di Oncologia Medica ed Ematologia - DAI di Internistica Polispecialistica- AOU Università degli studi della Campania "Luigi Vanvitelli"

Naples, , Italy

Site Status RECRUITING

Struttura semplice Sarcomi ossa e tessuti molli, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale

Naples, , Italy

Site Status RECRUITING

U.O.C. di Oncologia - Presidio Monaldi - AORN Ospedale dei Colli

Napoli, , Italy

Site Status RECRUITING

Istituto Oncologico Veneto

Padua, , Italy

Site Status RECRUITING

AOU Oncologia Medica

Parma, , Italy

Site Status RECRUITING

Oncologia traslazionale - ICS Maugeri di Pavia

Pavia, , Italy

Site Status RECRUITING

Oncologia Medica ed Ematologia, USL di Piacenza - Ospedale Guglielmo da Saliceto

Piacenza, , Italy

Site Status RECRUITING

Oncologia Medica 2 - Istituto Nazionale Tumori "Regina Elena"

Roma, , Italy

Site Status RECRUITING

UOC Oncologia Medica 1 - Istituti Fisioterapici Ospitalieri - Istituto Nazionale Tumori Regina Elena

Roma, , Italy

Site Status RECRUITING

Oncologia - Ospedale S. G. Moscati

Taranto, , Italy

Site Status RECRUITING

Oncologia Medica - Istituto Sacro Cuore Don Calabria

Verona, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Francesco Perrone, MD, PhD

Role: CONTACT

+390815903571 ext. +390815903571

Facility Contacts

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Domenico Galetta, MD

Role: primary

Saverio Cinieri, MD

Role: primary

Alberto Sobrero, MD

Role: primary

Lucia Del Mastro, MD

Role: primary

Emiliano Tamburini, MD

Role: primary

Silvana Leo, MD

Role: primary

Ugo De Giorgi, MD, PhD

Role: primary

Vincenzo Adamo, MD

Role: primary

Carla Ida Ripamonti, MD

Role: primary

Alice Bergamini, MD

Role: primary

Silvia Della Torre, MD

Role: primary

Sara Di Bella, MD

Role: primary

Sandro Pignata, MD, PhD

Role: primary

Alessandro Morabito, MD

Role: primary

Michele Orditura, MD

Role: primary

Antonio Pizzolorusso, MD

Role: primary

Vincenzo Montesarchio, MD

Role: primary

+390817065268

Vittorina Zagonel, MD

Role: primary

Marcello Tiseo, MD

Role: primary

Camillo Porta, MD

Role: primary

Luigi Cavanna, MD

Role: primary

Patrizia Vici, MD

Role: primary

Antonella Savarese, MD

Role: primary

Salvatore Pisconti, MD

Role: primary

Stefania Gori, MD

Role: primary

References

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Caminiti C, Maglietta G, Arenare L, Di Liello R, Migliaccio G, Barberio D, De Laurentiis M, Di Rella F, Nuzzo F, Pacilio C, Iodice G, Orditura M, Ciardiello F, Di Bella S, Cavanna L, Porta C, Giovanardi F, Ripamonti CI, Bilancia D, Aprile G, Ruelle T, Diodati F, Piccirillo MC, Iannelli E, Pinto C, Perrone F. Psychometric properties of patient-reported outcomes Common Terminology Criteria for adverse events (PRO-CTCAE(R)) in breast cancer patients: The prospective observational multicenter VIP study. Breast. 2024 Oct;77:103781. doi: 10.1016/j.breast.2024.103781. Epub 2024 Jul 20.

Reference Type DERIVED
PMID: 39059033 (View on PubMed)

Other Identifiers

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VIP

Identifier Type: -

Identifier Source: org_study_id

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