Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
EARLY_PHASE1
15 participants
INTERVENTIONAL
2021-05-07
2025-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
TRIPLE
Study Groups
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CBD
[11C]PBR28
The radiotracer, \[11C\]PBR28, will be administered at the beginning of each PET scan
Low-dose lipopolysaccharide
Subjects will receive intravenous lipopolysaccharide.
Intradermal Capsaicin
A small dose of capsaicin will be administered by intradermal injection.
Placebo
[11C]PBR28
The radiotracer, \[11C\]PBR28, will be administered at the beginning of each PET scan
Low-dose lipopolysaccharide
Subjects will receive intravenous lipopolysaccharide.
Intradermal Capsaicin
A small dose of capsaicin will be administered by intradermal injection.
Interventions
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[11C]PBR28
The radiotracer, \[11C\]PBR28, will be administered at the beginning of each PET scan
Low-dose lipopolysaccharide
Subjects will receive intravenous lipopolysaccharide.
Intradermal Capsaicin
A small dose of capsaicin will be administered by intradermal injection.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. No significant medical or neurological illness
3. No implanted metal devices that may pose a risk during MRI scanning
4. Within the annual permissible radiation exposure
5. Able to provide written informed consent.
Exclusion Criteria
2. Presence of metal in the body
3. Pregnancy or lactation
18 Years
55 Years
ALL
Yes
Sponsors
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National Center for Complementary and Integrative Health (NCCIH)
NIH
Yale University
OTHER
Responsible Party
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Mohini Ranganathan
Associate Professor of Psychiatry
Principal Investigators
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Mohini Ranganathan, MD
Role: PRINCIPAL_INVESTIGATOR
Yale University
Locations
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Connecticut Mental Health Center
New Haven, Connecticut, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2000026320
Identifier Type: -
Identifier Source: org_study_id
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