A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine

NCT ID: NCT04396236

Last Updated: 2025-10-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

1633 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-06-15

Study Completion Date

2026-11-30

Brief Summary

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The reason for this study is to see if lasmiditan is safe and effective in children aged 6 to 17 with migraine. The study will last up to 20 weeks and may include up to 4 visits.

Detailed Description

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Conditions

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Migraine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Lasmiditan High Dose

Lasmiditan administered orally with matching placebo to maintain the blind.

Group Type EXPERIMENTAL

Lasmiditan

Intervention Type DRUG

Administered orally

Placebo

Intervention Type DRUG

Administered orally

Lasmiditan Mid Dose

Lasmiditan administered orally with matching placebo to maintain the blind.

Group Type EXPERIMENTAL

Lasmiditan

Intervention Type DRUG

Administered orally

Placebo

Intervention Type DRUG

Administered orally

Lasmiditan Low Dose

Lasmiditan administered orally with matching placebo to maintain the blind.

Group Type EXPERIMENTAL

Lasmiditan

Intervention Type DRUG

Administered orally

Placebo

Intervention Type DRUG

Administered orally

Placebo

Placebo administered orally.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Administered orally

Interventions

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Lasmiditan

Administered orally

Intervention Type DRUG

Placebo

Administered orally

Intervention Type DRUG

Other Intervention Names

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LY573144

Eligibility Criteria

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Inclusion Criteria

* Participants must have a history of migraine with or without aura as defined by International Headache Society International Classification of Headache Disorders, 3rd edition (ICHD-3) (ICHD-3 2018) diagnostic criteria 1.1 or 1.2.1 and meets the following criteria:

* History of migraine attacks for more than 6 months
* Reports at least 2 and no more than 8 moderate-to-severe migraine attacks per month in the 2 months prior to screening visit
* Duration of a typical untreated migraine attack (excluding sleep) is greater than or equal to 3 hours
* Participant has not, by history, experienced satisfactory response with a previous migraine therapy, in the opinion of the investigator
* Participant must be able to swallow a tablet
* For participants taking migraine preventive medication, treatment regimen is stable and has been taken for at least 3 months prior to screening
* Participants must weigh at least 15 kilograms (kg)

Exclusion Criteria

* Participants must not be pregnant or nursing
* Participants must not have any acute, serious, or unstable medical condition
* Participants must not be actively suicidal or at significant risk for suicide, in the opinion of the investigator
Minimum Eligible Age

6 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Central Research Associates

Birmingham, Alabama, United States

Site Status COMPLETED

Rehabilitation & Neurological Services

Huntsville, Alabama, United States

Site Status RECRUITING

Phoenix Children's Hospital

Phoenix, Arizona, United States

Site Status NOT_YET_RECRUITING

Perseverance Research Center

Scottsdale, Arizona, United States

Site Status RECRUITING

Center for Neurosciences

Tucson, Arizona, United States

Site Status RECRUITING

Arkansas Children's

Little Rock, Arkansas, United States

Site Status COMPLETED

Core Healthcare Group

Cerritos, California, United States

Site Status COMPLETED

Pine Street Pediatrics

Exeter, California, United States

Site Status COMPLETED

Sun Valley Research Center

Imperial, California, United States

Site Status COMPLETED

Miller Children's & Women's Hospital Long Beach

Long Beach, California, United States

Site Status NOT_YET_RECRUITING

Sensa Health

Los Angeles, California, United States

Site Status RECRUITING

Orange County Research Institute - Ontario

Ontario, California, United States

Site Status RECRUITING

Children's Hospital Colorado

Aurora, Colorado, United States

Site Status COMPLETED

Colorado Springs Neurological Associates

Colorado Springs, Colorado, United States

Site Status COMPLETED

Yale University School of Medicine

New Haven, Connecticut, United States

Site Status RECRUITING

Children's National Medical Center

Washington D.C., District of Columbia, United States

Site Status COMPLETED

Wolfson Children's Hospital

Jacksonville, Florida, United States

Site Status COMPLETED

Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

Jacksonville, Florida, United States

Site Status COMPLETED

Biotech Pharmaceutical Group

Miami, Florida, United States

Site Status RECRUITING

New Horizon Research Center

Miami, Florida, United States

Site Status RECRUITING

Ezy Medical Research

Miami Lakes, Florida, United States

Site Status RECRUITING

Suncoast Clinical Research, Inc.

New Port Richey, Florida, United States

Site Status RECRUITING

Avanza Medical Research Center

Pensacola, Florida, United States

Site Status RECRUITING

Clinical Research Center of Florida

Pompano Beach, Florida, United States

Site Status COMPLETED

USF Health

Tampa, Florida, United States

Site Status RECRUITING

ForCare Clinical Research

Tampa, Florida, United States

Site Status COMPLETED

Palm Beach Neurology

West Palm Beach, Florida, United States

Site Status COMPLETED

Pediatric Neurology P.A.

Winter Park, Florida, United States

Site Status RECRUITING

Meridian Clinical Research, LLC

Savannah, Georgia, United States

Site Status NOT_YET_RECRUITING

Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, United States

Site Status RECRUITING

Hawaii Pacific Neuroscience

Honolulu, Hawaii, United States

Site Status RECRUITING

Medical Research Partners

Ammon, Idaho, United States

Site Status RECRUITING

Velocity Clinical Research, Boise

Meridian, Idaho, United States

Site Status COMPLETED

Chicago Headache Center and Research Institute

Chicago, Illinois, United States

Site Status RECRUITING

Chicago Headache Center and Research Institute - Naperville

Naperville, Illinois, United States

Site Status RECRUITING

Qualmedica Research, LLC

Evansville, Indiana, United States

Site Status RECRUITING

Fort Wayne Neurological Center - West

Fort Wayne, Indiana, United States

Site Status RECRUITING

Josephson Wallack Munshower Neurology, PC

Indianapolis, Indiana, United States

Site Status RECRUITING

Deaconess Clinic - Gateway Health Center

Newburgh, Indiana, United States

Site Status RECRUITING

Integrated Clinical Trial Services, Inc.

West Des Moines, Iowa, United States

Site Status RECRUITING

Alliance for Multispecialty Research, LLC

Wichita, Kansas, United States

Site Status ACTIVE_NOT_RECRUITING

Qualmedica Research, LLC

Bowling Green, Kentucky, United States

Site Status RECRUITING

University of Kentucky Chandler Medical Center

Lexington, Kentucky, United States

Site Status RECRUITING

Qualmedica Research, LLC

Owensboro, Kentucky, United States

Site Status RECRUITING

Children's Hospital New Orleans

New Orleans, Louisiana, United States

Site Status RECRUITING

Velocity Clinical Research - New Orleans

New Orleans, Louisiana, United States

Site Status RECRUITING

Pharmasite Research, Inc.

Baltimore, Maryland, United States

Site Status COMPLETED

ActivMed Practices and Research

Methuen, Massachusetts, United States

Site Status COMPLETED

MedVadis Research Corporation

Waltham, Massachusetts, United States

Site Status COMPLETED

New England Regional headache Center, Inc

Worcester, Massachusetts, United States

Site Status COMPLETED

Michigan State University

East Lansing, Michigan, United States

Site Status RECRUITING

Minneapolis Clinic of Neurology - Burnsville Office

Burnsville, Minnesota, United States

Site Status RECRUITING

SKY Integrative Medical Center/SKYCRNG

Ridgeland, Mississippi, United States

Site Status RECRUITING

Children's Mercy Hospital

Kansas City, Missouri, United States

Site Status COMPLETED

Clinvest Research LLC

Springfield, Missouri, United States

Site Status COMPLETED

Rochester Clinical Research, Inc.

Rochester, New York, United States

Site Status TERMINATED

Monroe Biomedical Research

Monroe, North Carolina, United States

Site Status RECRUITING

Accellacare - Piedmont

Statesville, North Carolina, United States

Site Status COMPLETED

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Site Status RECRUITING

Headache Center of Hope

Cincinnati, Ohio, United States

Site Status RECRUITING

Oregon Health and Science University

Portland, Oregon, United States

Site Status RECRUITING

Frontier Clinical Research, LLC

Scottdale, Pennsylvania, United States

Site Status RECRUITING

Frontier Clinical Research, LLC

Smithfield, Pennsylvania, United States

Site Status RECRUITING

Velocity Clinical Research, Providence

East Greenwich, Rhode Island, United States

Site Status RECRUITING

Tribe Clinical Research, LLC

Greenville, South Carolina, United States

Site Status RECRUITING

ARC Clinical Research at Wilson Parke

Austin, Texas, United States

Site Status COMPLETED

Driscoll Children's Hospital

Corpus Christi, Texas, United States

Site Status COMPLETED

Pain and Headache Centers of Texas

Houston, Texas, United States

Site Status COMPLETED

ClinPoint Trials

Waxahachie, Texas, United States

Site Status RECRUITING

Alliance for Multispecialty Research, LLC

Layton, Utah, United States

Site Status COMPLETED

Medical Research Partners - Logan

Logan, Utah, United States

Site Status RECRUITING

Northwest Clinical Research Center

Bellevue, Washington, United States

Site Status COMPLETED

Core Clinical Research

Everett, Washington, United States

Site Status COMPLETED

Seattle Children's Hospital

Seattle, Washington, United States

Site Status RECRUITING

Seattle Clinical Research Center

Seattle, Washington, United States

Site Status COMPLETED

Marshall Medical Center

Huntington, West Virginia, United States

Site Status RECRUITING

Frontier Clinical Research

Kingwood, West Virginia, United States

Site Status RECRUITING

UZ Brussel

Brussels, , Belgium

Site Status RECRUITING

UZ Gent

Ghent, , Belgium

Site Status COMPLETED

Private Practice - Dr. Sava Simona

Saint-Nicolas, , Belgium

Site Status COMPLETED

CHU d'Amiens-Picardie - Hôpital Sud

Amiens, , France

Site Status COMPLETED

Centre Hospitalier Universitaire Estaing

Clermont-Ferrand, , France

Site Status COMPLETED

Centre Hospitalier Intercommunal de Créteil

Créteil, , France

Site Status COMPLETED

Centre Hospitalier Régional Universitaire de Lille - Hôpital Roger Salengro

Lille, , France

Site Status COMPLETED

Centre Hospitalier Général de Mont de Marsan - Hôpital Layné

Mont-de-Marsan, , France

Site Status COMPLETED

Centre Hospitalier Universitaire de Toulouse - Hôpital Purpan

Toulouse, , France

Site Status COMPLETED

Private Practice - Dr. Irma Schöll

Bad Homburg, , Germany

Site Status RECRUITING

Universitaetsklinikum Freiburg

Freiburg im Breisgau, , Germany

Site Status RECRUITING

Panchshil hospital

Ahmedabad, , India

Site Status COMPLETED

Artemis hospital

Gurugram, , India

Site Status COMPLETED

Mangala Hospital & Mangala Kidney Foundation

Mangalore, , India

Site Status COMPLETED

Getwell Hospital and Research Institute

Nagpur, , India

Site Status COMPLETED

G.B. Pant Institute of Postgraduate Medical Education & Research

New Delhi, , India

Site Status COMPLETED

All India Institute of Medical Sciences

New Delhi, , India

Site Status COMPLETED

Sir Ganga Ram Hospital

New Delhi, , India

Site Status COMPLETED

Bhakti Vedanta Hospital and Research Institute

Thāne, , India

Site Status COMPLETED

Ospedale San Paolo Bari

Bari, , Italy

Site Status RECRUITING

IRCCS Istituto Neurologico Carlo Besta

Milan, , Italy

Site Status NOT_YET_RECRUITING

Universita degli Studi della Campania Luigi Vanvitelli

Napoli, , Italy

Site Status COMPLETED

Fondazione Istituto Neurologico C. Mondino

Pavia, , Italy

Site Status RECRUITING

Ospedale Pediatrico Bambino Gesù

Roma, , Italy

Site Status RECRUITING

Ospedale Filippo del Ponte Varese

Varese, , Italy

Site Status COMPLETED

Hiroshima City Hospital

Hiroshima, , Japan

Site Status RECRUITING

Tanaka Neurosurgery&Headache Clinic

Kagoshima, , Japan

Site Status RECRUITING

Nagaseki Headache Clinic

Kai, , Japan

Site Status RECRUITING

Hikita Pediatric clinic

Kiryū, , Japan

Site Status RECRUITING

Konan Hospital

Kobe, , Japan

Site Status RECRUITING

Umenotsuji Clinic

Kochi, , Japan

Site Status RECRUITING

Tatsuoka Neurology Clinic

Kyoto, , Japan

Site Status RECRUITING

Japanese Red Cross Kyoto Daiichi Hospital

Kyoto, , Japan

Site Status RECRUITING

Shinagawa Strings Clinic

Minato, , Japan

Site Status RECRUITING

Nishinomiya Municipal Central Hospital

Nishinomiya, , Japan

Site Status RECRUITING

Yamaguchi Clinic

Nishinomiya, , Japan

Site Status RECRUITING

Hyogo College of Medicine

Nishinomiya, , Japan

Site Status RECRUITING

Tominaga Hospital

Osaka, , Japan

Site Status RECRUITING

Sendai Headache and Neurology Clinic

Sendai, , Japan

Site Status RECRUITING

Tokyo Medical University Hospital

Shinjuku-ku, , Japan

Site Status RECRUITING

Tokyo Headache Clinic

Tokyo, , Japan

Site Status RECRUITING

Centro de Investigacion Medica Aguascalientes

Aguascalientes, , Mexico

Site Status RECRUITING

Unidad de Investigación en Salud

Chihuahua City, , Mexico

Site Status RECRUITING

AGNI Research and Assessment S.C.

Cuernavaca, , Mexico

Site Status COMPLETED

PanAmerican Clinical Research - Guadalajara

Guadalajara, , Mexico

Site Status RECRUITING

Hospital Infantil de Mexico Federico Gomez

Mexico City, , Mexico

Site Status COMPLETED

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

Monterrey, , Mexico

Site Status RECRUITING

Canisius-Wilhelmina Ziekenhuis

Nijmegen, , Netherlands

Site Status RECRUITING

Isala, locatie Zwolle

Zwolle, , Netherlands

Site Status RECRUITING

Dr. Samuel Sanchez PSC

Caguas, , Puerto Rico

Site Status RECRUITING

Puerto Rico Health Institute

Dorado, , Puerto Rico

Site Status RECRUITING

Ponce Medical School Foundation Inc.

Ponce, , Puerto Rico

Site Status RECRUITING

Wellness clinical Research Vega Baja

Vega Baja, , Puerto Rico

Site Status RECRUITING

Prof. Dr. Alexandru Obregia Psychiatry Hospital

Bucharest, , Romania

Site Status RECRUITING

Constanta County Emergency Clinical Hospital Sf.Ap.Andrei

Constanța, , Romania

Site Status COMPLETED

Spitalul clinic de urgenta pentru copii Sf. Maria

Iași, , Romania

Site Status RECRUITING

Limited Liability Company University Clinic of headaches

Moscow, , Russia

Site Status TERMINATED

Sibneyromed Urban Neurological Center

Novosibirsk, , Russia

Site Status TERMINATED

Saint-Petersburg State Pediatric Medical University

Saint Petersburg, , Russia

Site Status TERMINATED

Hospital Universitari Vall d'Hebron

Barcelona, , Spain

Site Status RECRUITING

Hospital de la Santa Creu i Sant Pau

Barcelona, , Spain

Site Status COMPLETED

Hospital Sant Joan de Déu

Esplugues de Llobregat, , Spain

Site Status RECRUITING

Hospital Universitario 12 de Octubre

Madrid, , Spain

Site Status RECRUITING

Hospital Universitario Quironsalud Madrid

Pozuelo de Alarcón, , Spain

Site Status COMPLETED

Hospital Universitari Parc Tauli

Sabadell, , Spain

Site Status RECRUITING

Hospital Universitario Virgen Del Rocio

Seville, , Spain

Site Status RECRUITING

Hospital Clínico Universitario de Valladolid

Valladolid, , Spain

Site Status RECRUITING

Royal Hospital for Sick Children

Glagow, , United Kingdom

Site Status COMPLETED

James Paget University Hospital

Great Yarmouth, , United Kingdom

Site Status COMPLETED

Re:Cognition Health - London

London, , United Kingdom

Site Status COMPLETED

Great Ormond Street Hospital For Children NHS Foundation Trust

London, , United Kingdom

Site Status COMPLETED

Queen's Medical Centre, Nottingham University Hospitals

Nottingham, , United Kingdom

Site Status COMPLETED

Stepping Hill Hospital

Stockport, , United Kingdom

Site Status COMPLETED

Countries

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United States Belgium France Germany India Italy Japan Mexico Netherlands Puerto Rico Romania Russia Spain United Kingdom

Central Contacts

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Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Role: CONTACT

1-317-615-4559

Physicians interested in becoming principal investigators please contact

Role: CONTACT

Facility Contacts

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Role: primary

256-885-9708

Role: primary

480-471-6132

Role: primary

520-320-2157

Role: primary

562-490-3580

Role: primary

909-395-9788

Role: primary

305-226-3933

Role: primary

305-793-1853

Role: primary

727-781-3655

Role: primary

850-477-7900

Role: primary

912-790-4837

Role: primary

470-317-3604

Role: primary

808-564-6141

Role: primary

208-681-9070

Role: primary

812-205-2475

Role: primary

260-436-2416x2179

Role: primary

812-492-5011

Role: primary

515-223-2300

Role: primary

270-685-4589

Role: primary

270-685-4589

Role: primary

985-273-0855

Role: primary

517-884-8922

Role: primary

601-617-7717

Role: primary

704-283-7359

Role: primary

513-898-9400

Role: primary

724-220-5281

Role: primary

724-569-8036

Role: primary

864-334-0141

Role: primary

972-937-1640

Role: primary

208-681-9070

Role: primary

206-987-2078

Role: primary

304-441-2006

Role: primary

003224749575

Role: primary

49 (0)761 27043150

Role: primary

390805843280

Role: primary

+390382380289

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

81120023812

Role: primary

52 614 437 2837

Role: primary

3332705374

Role: primary

31243658210

Role: primary

787-746-3136

Role: primary

7877961049

Role: primary

787-840-2505

Role: primary

787-654-9444

Role: primary

0040742626432

Role: primary

983420000

Related Links

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https://trials.lillytrialguide.com/en-US/trial/7KMzdVunyLy89yfITjyNO2

A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine (PIONEER-PEDS1)

Other Identifiers

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H8H-MC-LAHV

Identifier Type: OTHER

Identifier Source: secondary_id

2019-004378-24

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

16927

Identifier Type: -

Identifier Source: org_study_id

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