Facial Demodicosis and Ocular Demodicosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-13

Study Completion Date

2020-12-14

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To understand the association between facial demodicosis and ocular demodicosis, we plan to enroll patients with facial demodicosis, ocular demodicosis, or both, in order to analyze their clinical presentations, the density of Demodex infestation over facial skin and eyelashes, and possible risk factors of the two diagnoses.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Treatment of Ocular Demodex Infestation With Topical Ivermectin Cream 1%

NCT05213585

The Focus of the Study is to Assess the Effectiveness of Topical Ivermectin on Eliminating Eyelash Sleeves

UNKNOWN PHASE1

Topical 0.5% Ivermectin Cream for Treatment of Demodicidosis

NCT02036229

Demodicidosis Rosacea

UNKNOWN PHASE3

Could Wearing Face Mask Have Affected Demodex Parasite

NCT06185699

Pandemic, COVID-19 Demodex Infestation

COMPLETED NA

Combining Topical Imiquimod With Local Radiotherapy for Treatment of Mycosis Fungoides

NCT05838599

Mycosis Fungoides

RECRUITING EARLY_PHASE1

A Trial of Epilation Verses Surgery for Minor Trichiasis

NCT00522912

Trachomatous Trichiasis

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Although facial demodicosis and ocular demodicosis are described in a variety of clinical presentations, the association between the two diagnoses is not clearly identified.

Clinically, we plan to enroll 120 patients with facial demodicosis, ocular demodicosis. We will obtain their basic information, medical history, medication, and lifestyle. We will evaluate their clinical features. We will also perform quantitative tests including direct microscopic examination and cilia epilation test:

1. Direct microscopic examination: On glabella and bilateral cheeks, follicular contents in the 1-cm × 1-cm area will be squeezed out. The contents are transferred onto a glass slide, covered with mineral oil and a cover slide, and examined under the microscope.
2. Epilation: Four (4) non-adjacent cilia will be pulled from each upper eyelid and examined under the microscope. The total Demodex counts are recorded.

We will analyze the clinical presentations, the density of Demodex infestation, and possible risk factors of the two diagnoses.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Demodex Infestation Rosacea Blepharitis Meibomian Gland Dysfunction Pityriasis Folliculorum

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Facial Demodicosis

1. Clinical presentation of facial skin matches any of the followings:

1. Pityriasis folliculorum.
2. Papulopustular lesion.
3. Rosacea.
2. Demodex infestation detected by direct microscopic examination ≥ 5 mites/cm2.

No interventions assigned to this group

Ocular Demodicosis

1. Clinical presentation of ocular region matches any of the followings:

1. Chronic blepharitis.
2. Eyelash abnormalities: trichiasis, distichiasis, madarosis.
3. Meibomian gland dysfunction.
4. Recurrent chalazion.
5. Ocular rosacea.
2. Demodex infestation detected by cilia epilation test ≥ 1 mite/eyelid.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Patient with a diagnosis of facial demodicosis or ocular demodicosis.

A. Facial demodicosis defined as both 1 and 2:

1. Clinical presentation of facial skin matches any of the followings:

1. Pityriasis folliculorum.
2. Papulopustular lesion.
3. Rosacea.
2. Demodex infestation detected by direct microscopic examination ≥ 5 mites/cm2.

B. Ocular demodicosis defined as both 3 and 4:
3. Clinical presentation of ocular region matches any of the followings:

1. Chronic blepharitis.
2. Eyelash abnormalities: trichiasis, distichiasis, madarosis.
3. Meibomian gland dysfunction.
4. Recurrent chalazion.
5. Ocular rosacea.
4. Demodex infestation detected by cilia epilation test ≥ 1 mite/eyelid.

Exclusion Criteria

1. Usage of oral Ivermectin, topical Ivermectin or topical tea tree oil in the past 1 month.
2. Patient who cannot tolerate direct microscopic examination or cilia epilation test.

Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No