Bone Morphogenetic Protein-2 In Grade II Furcation Defects.
NCT ID: NCT04372420
Last Updated: 2020-05-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
44 participants
INTERVENTIONAL
2017-12-05
2019-10-10
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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RhBMP-2
RhBMP-2 belongs to TGF-β super family with osteoinductive property which is capable of promoting bone formation
RhBMP-2 absorbable sponge in grade II furcation
The collagen sponge is impregnated with rhBMP-2 at a concentration of 0.5 μg/ml/1cm3 and were stored at 4°C. This rhBMP-2 impregnated collagen sponge was then dispensed at grade II furcation site
PLATELET RICH FIBRIN
Platelet rich fibrin(PRF) is a healing biomaterial with a great potential for bone and soft tissue regeneration, without any inflammatory reactions
PLATELET RICH FIBRIN in grade II furcation
For preparation of PRF, patient's venous blood is collected into 10ml glass tube or glass-coated plastic tube and centrifuged at 2700 rpm for 12min which leads to two different layers in the test tube, the upper platelet rich fibrin and the lower RBC portion. The formed PRF clot could then be removed from the glass tube and used in grade II furcation
Interventions
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RhBMP-2 absorbable sponge in grade II furcation
The collagen sponge is impregnated with rhBMP-2 at a concentration of 0.5 μg/ml/1cm3 and were stored at 4°C. This rhBMP-2 impregnated collagen sponge was then dispensed at grade II furcation site
PLATELET RICH FIBRIN in grade II furcation
For preparation of PRF, patient's venous blood is collected into 10ml glass tube or glass-coated plastic tube and centrifuged at 2700 rpm for 12min which leads to two different layers in the test tube, the upper platelet rich fibrin and the lower RBC portion. The formed PRF clot could then be removed from the glass tube and used in grade II furcation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* grade II furcation involvement and probing pocket depth of ≥5mm
Exclusion Criteria
* subjects who underwent radiotherapy or chemotherapy in the past 12 months
* patients having uncontrolled periodontal disease and
* subjects smoking ≥10 cigarettes per day were excluded
20 Years
55 Years
ALL
Yes
Sponsors
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SVS Institute of Dental Sciences
OTHER
Responsible Party
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Dr R Viswa Chandra
Principal Investigator
Locations
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RV Chandra
Hyderabad, Telangana, India
Countries
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Other Identifiers
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SVSIDS/PERIO/3/2017
Identifier Type: -
Identifier Source: org_study_id
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