BRIDGE Percutaneous Nerve Stimulation for Cesarean Delivery Pain Control

NCT ID: NCT04365465

Last Updated: 2023-01-18

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-17

Study Completion Date

2021-06-30

Brief Summary

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This is a randomized, placebo controlled and natural-history controlled trial to investigate the effectiveness of NSS-2 BRIDGE® for postpartum women with AND without opioid use disorder (OUD). The purpose of this pilot investigation is to establish feasibility/acceptability of the trial design.

Detailed Description

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This study is a randomized control trial with the following arms: 1) active device; 2) placebo device; 3) non-intervention (active control). The devices will be placed while women are still feeling pain relief from labor epidural analgesia (after delivering vaginally) or from spinal or epidural anesthesia (after delivering by cesarean). By applying the devices while women are still relatively pain-free, a preventative/pre-emptive approach to pain management in women at risk for severe postpartum pain is taken. The study will enroll women with and without OUD and follow them for five days postpartum.

Conditions

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Opioid-use Disorder Pain, Postoperative

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This study is a randomized control trial with the following arms: 1) active device; 2) placebo device; 3) non-intervention (active control).
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Among participants who receive a device, both the participant and care providers/investigators will be blinded to whether the device is active or placebo. There is no blinding among participants who do not receive a device.

Study Groups

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Active device

Participants in this arm will receive an active NSS-Bridge device placed immediately following their cesarean section.

Group Type EXPERIMENTAL

NSS-2 Bridge

Intervention Type DEVICE

The NSS-2 BRIDGE (Appendix 1) is a battery operated and disposable percutaneous auricular nerve field stimulator (Innovative Health Solutions, Versailles, IN, USA), that was recently cleared by the FDA and assigned a Class II Risk Designation; a class which includes surgical drapes, pumps and power wheelchairs.

Placebo device

Participants in this arm will receive an inactive (sham) NSS-Bridge device placed immediately following their cesarean section.

Group Type SHAM_COMPARATOR

Inactive NSS-2 Bridge

Intervention Type DEVICE

This is a sham device which is identical to the active NSS-2 Bridge, but will not provide percutaneous auricular nerve field stimulation when applied.

Active Control

Participants in this arm will receive no device, only the standard postpartum pain control.

Group Type ACTIVE_COMPARATOR

Active control

Intervention Type OTHER

Active control will include standard of care pain management during the postoperative period. Participants in this intervention arm will not receive or wear a device.

Interventions

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NSS-2 Bridge

The NSS-2 BRIDGE (Appendix 1) is a battery operated and disposable percutaneous auricular nerve field stimulator (Innovative Health Solutions, Versailles, IN, USA), that was recently cleared by the FDA and assigned a Class II Risk Designation; a class which includes surgical drapes, pumps and power wheelchairs.

Intervention Type DEVICE

Inactive NSS-2 Bridge

This is a sham device which is identical to the active NSS-2 Bridge, but will not provide percutaneous auricular nerve field stimulation when applied.

Intervention Type DEVICE

Active control

Active control will include standard of care pain management during the postoperative period. Participants in this intervention arm will not receive or wear a device.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Pregnant
* Third trimester
* Cesarean delivery under neuraxial anesthesia
* Healthy, clean skin
* 18 years or older

Exclusion Criteria

* Not fluent in English (surveys are validated in English language), unable to participate in informed consent discussions, or unable to give informed consent for any reason
* Unable to participate fully in all study procedures for any reason
* Cesarean delivery under general anesthesia
* History of hemophilia
* Pacemakers or implantable electronic devices
* History of psoriasis
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Pittsburgh

OTHER

Sponsor Role collaborator

Grace Lim, MD, MS

OTHER

Sponsor Role lead

Responsible Party

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Grace Lim, MD, MS

Assistant Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Grace Lim, MD, MS

Role: PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Locations

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UPMC Magee Womens Hospital

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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UL1TR001857

Identifier Type: NIH

Identifier Source: secondary_id

View Link

STUDY19110257

Identifier Type: -

Identifier Source: org_study_id

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