Electroconvulsive Therapy and Neuroradiology

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-09-01

Study Completion Date

2018-10-10

Brief Summary

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The study will apply state of the art radiology through advanced magnetic resonance imaging (MRI) techniques to investigate structural and functional brain effects of ECT.

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Detailed Description

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As a multi-disciplinary collaboration, imaging findings will be correlated to psychiatric response parameters, neuropsychological functioning as well as neurochemical and genetic biomarkers that can elucidate the underlying mechanisms. The aim is to document both treatment effects and potential harmful effects of ECT.

Sample: n = 40 patients in a major depressive episode (bipolar and major depressive disorder). Two control groups with n = 15 in each group: age and gender matched healthy volunteers not receiving ECT and patients undergoing electrical cardioversion (ECV) for atrial fibrillation (AF). Observation time: six months.

Conditions

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Depression Electroconvulsive Therapy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients, depression

Patients who receive ECT as part of clinical care

Electroconvulsive therapy

Intervention Type DEVICE

Healthy

Healthy controls who do not receive ECT but otherwise the same assessments.

No interventions assigned to this group

Patients, atrial fibrilation

Patients who receive Electro Cardio Version (ECV) due to Atrial Fibrilation

No interventions assigned to this group

Interventions

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Electroconvulsive therapy

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients (age \> 18) referred to the ECT-unit and accepted for treatment because of moderate and severe depression,
* fulfilling the criteria for the following ICD-10 diagnoses: F31.3 and F31.4; F32.1 and F32.2 and F32.3; F33.1 and F33.2 and F33.3.
* symptom intensity must be verified by a score ≥ 25 on the Montgomery and Åsberg Depression Rating Scale (MADRS).

Exclusion Criteria

* ECT treatment within the last 12 months.
* Pregnancy.
* Patients unable to give written informed consent (according to the responsible clinician or ECT responsible).
* Patients who cannot participate in the MRI scanning because of contraindications to MRI.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No