Neurobiological Changes When Treating Depression With Electroconvulsive Therapy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-12-31

Brief Summary

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The purpose of this study is to determine functional and structural changes in brain following treatment of severe depression with electroconvulsive therapy with correlation to clinical outcome. Our hypothesis is that there are state-dependent changes in functional connectivity within specific neurocircuits systems, as well as structural plasticity changes in hippocampus, when recovering from depression.

Detailed Description

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The study is a prospective, within-subject, observational follow-up study in individuals with depression who receive electroconvulsive therapy (ECT)at a psychiatric clinic. We will use a consecutive sampling method and patient referred for ECT by their psychiatrist will be screened for inclusion and asked for participation. Both in - and outpatients can be included. At three occasions (before treatment, after four week and after three months) patients will be assessed with clinical ratings, cognitive tests, functional and structural magnetic resonance imaging and biomarkers for cell proliferation.

Conditions

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Depression

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Depression, ECT

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* major depressive disorder
* depressive episode in bipolar disorder
* age 18 - 65 years

Exclusion Criteria

* alcohol- and/or drug dependence or abuse in the past 3 months
* severe/life-threatening medical disease
* pregnancy
* type I diabetes
* neurodegenerative disorder
* inability to give written informed consent to participation in the study
* contradiction to MRI scanning.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Pia Nordanskog

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Linkoeping University, Linkoeping University Hospital

Linköping, Östergötland County, Sweden

Site Status RECRUITING

Countries

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Sweden

Facility Contacts

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Pia Nordanskog, MD

Role: primary

Other Identifiers

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LinkoepingUniversity

Identifier Type: OTHER

Identifier Source: secondary_id

LIU2012/310-31

Identifier Type: -

Identifier Source: org_study_id

Neurobiological Changes When Treating Depression With Electroconvulsive Therapy - a Longitudinal Observational Study