Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
3240 participants
OBSERVATIONAL
2017-04-01
2025-01-01
Brief Summary
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Detailed Description
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Gut microbiota plays an important roles in the chronic liver disease. It can suppress the progression of the liver disease by moulation gut microbiota.
The investigators are still evaluating the effect of gut microbiota on the liver disease.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Fecal DNA
Extraction fecal DNA and compare disease group to normal group
DNA extraction
Extraction fecal DNA and compare disease group to normal group
Interventions
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DNA extraction
Extraction fecal DNA and compare disease group to normal group
Eligibility Criteria
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Inclusion Criteria
* Normal : AST or ALT level \< 50IU/L, BMI \< 25
* Liver disease : AST or ATL level ≥ 50IU/L, BMI ≥ 25
* Patients hospitalized with chronic liver disease (viral hepatitis, alcoholic liver disease, non-alcoholic liver disease, cirrhosis, liver cancer)
Exclusion Criteria
* Liver disease : AST or ALT level \< 50IU/L, BMI \< 25
* If the patient refuses
31 Years
82 Years
ALL
Yes
Sponsors
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Chuncheon Sacred Heart Hospital
OTHER
Responsible Party
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Ki Tae Suk
Proffesor
Locations
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Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital
Chuncheon, , South Korea
Countries
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References
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Park IG, Yoon SJ, Won SM, Oh KK, Hyun JY, Suk KT, Lee U. Gut microbiota-based machine-learning signature for the diagnosis of alcohol-associated and metabolic dysfunction-associated steatotic liver disease. Sci Rep. 2024 Jul 12;14(1):16122. doi: 10.1038/s41598-024-60768-2.
Ganesan R, Gupta H, Jeong JJ, Sharma SP, Won SM, Oh KK, Yoon SJ, Han SH, Yang YJ, Baik GH, Bang CS, Kim DJ, Suk KT. Characteristics of microbiome-derived metabolomics according to the progression of alcoholic liver disease. Hepatol Int. 2024 Apr;18(2):486-499. doi: 10.1007/s12072-023-10518-9. Epub 2023 Mar 31.
Other Identifiers
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STOOL
Identifier Type: -
Identifier Source: org_study_id
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