Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
210 participants
OBSERVATIONAL
2020-03-09
2024-01-12
Brief Summary
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We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using ultra-high-field 7 Tesla MRI. We will optimise 7T Time-of-Flight MR angiography, blood suppressed MR sequence and phase-contrast (PC) MR angiography for visualization of perforating lenticulostriate arteries. This optimised sequences will be used to determine the range of arterial pathologies seen in individuals presenting with lacunar strokes. The pathologies of the perforating lenticulostriate arteries will be correlated with conventional clinical risk factors, cognition and radiological markers of SVD.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients with lacunar stroke due to SVD
7 Tesla Magnetic Resonance Imaging
Diagnostic Imaging
Brief Memory and Executive Test
Cognitive Assessment
Healthy stroke free volunteers
7 Tesla Magnetic Resonance Imaging
Diagnostic Imaging
Interventions
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7 Tesla Magnetic Resonance Imaging
Diagnostic Imaging
Brief Memory and Executive Test
Cognitive Assessment
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. Age\<18;
3. Stroke aetiology due to cardio-embolism or large vessel disease;
4. Lacunar infarcts \>1.5cm;
5. Severe stroke (NIHSS score ≥16);
6. Evidence of cortical infarct of any size;
7. Other major neurological diseases;
8. Severe systemic diseases such as heart failure, liver failure and kidney failure or any illness in the judgement of the investigator that could affect participation in the study;
9. MRI contraindications e.g. metal objects in or on the body, claustrophobia, pregnancy, known allergy to gadolinium containing contrast agent, impaired renal function with estimated glomerular filtration rate (eGFR) \<59ml/min/1.73m2.
18 Years
99 Years
ALL
Yes
Sponsors
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Cambridge University Hospitals NHS Foundation Trust
OTHER
Wolfson Brain Imaging Centre
UNKNOWN
University of Cambridge
OTHER
Responsible Party
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Christopher Osuafor
Study Co-ordinator and Co-investigator
Principal Investigators
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Hugh Markus, FMedSci
Role: PRINCIPAL_INVESTIGATOR
University of Cambridge Department of Clinical Neurosciences
Locations
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University of Cambridge
Cambridge, Cambridgeshire, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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A095132
Identifier Type: -
Identifier Source: org_study_id
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