Central Catheters Used for Chemotherapy in Women With Breast Cancer

NCT ID: NCT04324346

Last Updated: 2021-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-04-01

Study Completion Date

2021-02-01

Brief Summary

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The overall aim of this study is to evaluate two different central venous lines, PICC-lines (PICC) and subcutaneous venous access ports (SVAP) used for chemotherapy in women with breast cancer. The study will compare complications, material wear of the catheters used, patients'- and health care professionals' experiences, and costs. The study will give knowledge about which central venous access that is the most advantageous regarding adjuvant chemotherapy for women with breast cancer in the aspects of safety, quality of care, and quality of life.

Detailed Description

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N=250 women between 18 and 70 years of age with invasive breast cancer who are allocated to adjuvant or neo adjuvant chemotherapy during 18 weeks at the Department of Oncology at Karolinska University Hospital , Stockholm Sweden are eligible to participate in the present study. Exclusion criteria are cognitive dysfunction and/or inability to understand Swedish. Before participation an informed consent will be collected. The patients will be randomized to receive a PICC or a SVAP. Complications will be registered as well as the treatments.

Bacterial cultures will be taken at removal of PICC/SVAP. The used PICC/SVAP will be transported to the Royal Institute of Technology (KTH) and subjected to material analyses. Comparison with reference materials from the in-vitro study and with new reference catheters will be performed. Patient assessments with questionnaire concerning HRQL, illness perception, body imaging, life style and sleep disturbance will be collected at baseline and at the last chemotherapy session. Interviews with the patients about life situations will be conducted half through the chemotherapy treatment period.In- and out-patients costs, i.e. medication, materials, costs related to the care of the PICC/SVAP, costs for complications, additional costs for the patients regarding the treatment, etc., will be monitored and registered. In- and out-patient costs will also be monitored. Data from medical records concerning treatments for complications will also be taken into consideration.

Conditions

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Catheter Related Complications

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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PICC-Line

Women allocated to PICC-line when receiving chemotherapy

Group Type EXPERIMENTAL

FEC75 (or EC90) x 6

Intervention Type DRUG

Type of Chemotherapy

FEC100 + Taxotere (EC90 + Taxotere) 3+3

Intervention Type DRUG

Type of Chemotherapy

Paclitaxel

Intervention Type DRUG

Type of Chemotherapy

Subcutaneous Venous Access Port (SVAP)

Women allocated to SVAP when receiving chemotherapy

Group Type EXPERIMENTAL

FEC75 (or EC90) x 6

Intervention Type DRUG

Type of Chemotherapy

FEC100 + Taxotere (EC90 + Taxotere) 3+3

Intervention Type DRUG

Type of Chemotherapy

Paclitaxel

Intervention Type DRUG

Type of Chemotherapy

Interventions

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FEC75 (or EC90) x 6

Type of Chemotherapy

Intervention Type DRUG

FEC100 + Taxotere (EC90 + Taxotere) 3+3

Type of Chemotherapy

Intervention Type DRUG

Paclitaxel

Type of Chemotherapy

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adjuvant or neo adjuvant chemotherapy,
* speak Swedish

Exclusion Criteria

* cognitive dysfunction
* and/or inability to understand Swedish,
* recurrent breast cancer
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Karolinska Institutet

OTHER

Sponsor Role collaborator

KTH Royal Institute of Technology

OTHER

Sponsor Role collaborator

Karolinska University Hospital

OTHER

Sponsor Role collaborator

Stockholm South General Hospital

OTHER

Sponsor Role collaborator

Norwegian University of Science and Technology

OTHER

Sponsor Role collaborator

Swedish Red Cross University College

OTHER

Sponsor Role lead

Responsible Party

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Gunilla Bjorling

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gunilla Björling, PhD

Role: STUDY_CHAIR

The Swedish Red Cross University College

Locations

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Onkologiska kliniken, Karolinska University Hospital, Danderyd Hospital

Stockholm, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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RKH2014.1

Identifier Type: -

Identifier Source: org_study_id

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