Complete Local Response to Neoadjuvant Chemotherapy in Patients With Muscle Invasive Bladder Cancer Evaluated by 15O-H2O PET/MR

NCT ID: NCT04321707

Last Updated: 2021-07-28

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 54 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-05-27
• Study Completion Date: 2023-03-31

Brief Summary

Treatment of localized muscle invasive bladder cancer (MIBC) is radical cystectomy. Neoadjuvant chemotherapy (NAC) improves survival.

Approximately 50-60% of all MIBC patients undergoing NAC before cystectomy are histopathological without remnant tumor in the cystectomy specimen (T0). However, there is currently no optimal method to evaluate whether the patient is true T0 or has remnant tumor in need for consolidating radical treatment. The study aim is to investigate if 15O-H2O PET/MR can predict complete local response to neoadjuvant chemotherapy in patients with MIBC and thereby identify potential candidates for organ preservation.

Detailed Description

For patients with MIBC treated with NAC and radical cystectomy there is currently no good way of evaluating whether the patient is true T0 or has remnant tumor in need for consolidating radical treatment. Methods for better selection of patients that potentially can avoid cystectomy is therefore needed.

15O-labeled water (H2O) is the gold standard for PET quantification of regional tissue perfusion. 15O-H2O has been validated as a freely diffusible tracer for measuring perfusion in the myocardium and cerebral blood flow and 15O-H2O PET is the golden standard for noninvasive imaging to quantify tumor blood flow (TBF).

Method: Patients scheduled for NAC followed by radical cystectomy due to histologically documented MIBC stage cT2-4a in the urinary bladder will be included. A 15O-H2O PET/MR scan will be performed at time of inclusion (baseline) and again after NAC prior to cystectomy.

Hypothesis: We hypothesize that changes in tumor architecture and perfusion estimated with 15O-H2O PET/MR measurements and clinical evaluation during NAC can identify patients with complete local response to chemotherapy and therefore select patients to avoid radical cystectomy.

Perspectives: This study will be the first to use 15O-H2O as tracer in bladder cancer. If proven efficient, evaluation of patients undergoing NAC with 15O-H2O PET/MR could potentially safely select patients for a true bladder sparring approach and potentially give some patients the choice of chemotherapy monotherapy, or in combination with other systemic oncological treatments like immunotherapy. If successful, this should be followed by randomized studies to document the clinical benefit and potentially reduce cost and increase quality of life by safely selecting patients for bladder sparring treatment of bladder cancer.

Conditions

Bladder Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

15O-H2O PET/MR

All included patients will have two 15O-H2O PET/MR scan performed.

Group Type: EXPERIMENTAL

15O-H2O PET/MR

Intervention Type: RADIATION

All included patients will have a 15O-H2O PET/MR scan performed at baseline and a scan performed after NAC, prior to cystectomy.

Interventions

15O-H2O PET/MR

All included patients will have a 15O-H2O PET/MR scan performed at baseline and a scan performed after NAC, prior to cystectomy.

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• Diagnosis of MIBC stage cT2-4a.
• Preoperative PET/CT of thorax, abdomen, and pelvis with no suspicion of organ metastases or lymph node metastasis outside the surgical field.
• ≥18 years of age at the time of signing the Informed Consent Form. Renal function of eGFR > 60 ml/min/1,73 m2.
• Physically fit for NAC.
• Clinical decision with patient accept of NAC before cystectomy.
• Mentally healthy. Signed Informed Consent Form.

Exclusion Criteria

• Unfit for MRI:

• Claustrophobia.
• Problems with seating arrangements (e.g. pain or involuntary movement).
• Maximal shoulder width larger than 55 cm.
• Circumference larger than 160 cm.
• Weight above 250 kg.
• Metallic implants or other metallic foreign bodies.
• Pacemaker, ICD, or pace electrodes.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jørgen Bjerggaard Jensen

OTHER

Sponsor Role: lead

Responsible Party

Jørgen Bjerggaard Jensen

Professor, Consultant, MD, DMSc

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Department of Urology, Aarhus University Hopsital

Aarhus, , Denmark

Site Status: RECRUITING

Countries

Denmark

Central Contacts

Jørgen Bjerggaard Jensen, Professor, consultant, MD

Role: CONTACT

bjergaard@skejby.rm.dk

004578452617

Stefanie Korsgaard Körner, MD

Role: CONTACT

stkoer@rm.dk

004530915431

Facility Contacts

Jørgen Bjerggaard Jensen, Professor, consultant, MD

Role: primary

bjerggaard@skejby.rm.dk

004578452617

Stefanie Kosgaard Körner, MD

Role: backup

stkoer@rm.dk

004530915431

Other Identifiers

MAINTAIN

Identifier Type: -

Identifier Source: org_study_id