Evaluation of the Immediate Effect and Safety of DMA™ Novel Muscle Stimulation Technology

NCT ID: NCT04296201

Last Updated: 2021-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-01

Study Completion Date

2021-02-15

Brief Summary

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A total of at least 15 and up to 17 healthy subjects at a single site, aged 25-45 years old, who wish to receive a lifting effect and improved muscle definition, will be included in the study.

The procedure will include treatments with the Legend Pro™ DMA™ technology. Photos will be obtained at pre-defined time points throughout the study.

Detailed Description

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Single center, prospective, open Label with Before \& After Study Design. This study is designed to evaluate the immediate efficacy and safety of Legend Pro™'s DMA™ muscle stimulation technology. Treatment areas will include the face, buttocks, or abdominal region. Each subject will receive 1 treatment with no follow-up visits required. Interim assessment will be held after half of the study population has received treatment.

The study population will be divided into three arms as follows:

* 5 female subjects will receive treatment in the face area
* 5 female subjects will receive treatment in the buttocks area
* 5 male subjects will receive treatment in the abdominal region

Conditions

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Skin Laxity Muscle Contracture

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment in the face area

5 female subjects will receive treatment in the face area

Group Type EXPERIMENTAL

DMA treatment

Intervention Type DEVICE

Each arm will receive the DMA treatment in a specific area on the body to observe immediate effect.

Treatment in the buttocks area

5 female subjects will receive treatment in the buttocks area

Group Type EXPERIMENTAL

DMA treatment

Intervention Type DEVICE

Each arm will receive the DMA treatment in a specific area on the body to observe immediate effect.

Treatment in the abdominal region

5 male subjects will receive treatment in the abdominal region

Group Type EXPERIMENTAL

DMA treatment

Intervention Type DEVICE

Each arm will receive the DMA treatment in a specific area on the body to observe immediate effect.

Interventions

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DMA treatment

Each arm will receive the DMA treatment in a specific area on the body to observe immediate effect.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Subject read, understood and signed the Consent Form
2. Healthy male or female aged 25-45 years,
3. Fitzpatrick skin type 1-6
4. Subject is capable of reading, understanding and following instructions of the procedure to be applied.
5. Subject is able and willing to comply with the treatment.
6. Women of child-bearing potential are required to use two forms of reliable methods of birth control (such as an intrauterine device, birth control pills, condom with spermicidal, NuvaRing, partner with vasectomy, Implanon or other FDA-approved devices, or abstinence) during the course of the study.

Exclusion Criteria

General

1. Subject is female who is pregnant, lactating, or plans to become pregnant during the study period or had given birth less than 6 months ago.
2. Concurrent participation in any other study.

Specific to the treatment and treatment area
3. Subject has a pacemaker or internal defibrillator, implanted neurostimulators or any other internal electric device or patient who had an implant in the past.
4. Subject has metal or other implants in the treatment area (Not including dental fillings, implants and crowns).
5. Subject has significant concurrent skin conditions affecting areas to be treated such as sores, bleeding, skin fragility, eczema or psoriasis.
6. Subject has burned, blistered, irritated, or sensitive skin due to excessive fresh tanning in areas to be treated or is unlikely to refrain from excessive tanning during the study.

Other treatments
7. Subject has used oral isotretinoin (Accutane or Roaccutan®) within 6 months prior to study enrollment or plans use during the course of the study.
8. Subject has used topical retinoids in past 1 month

Medical conditions/ use of medication
9. Subject has current or history of systemic cancer; premalignant skin lesion or skin concern treatment area.
10. Subject has severe concurrent conditions such as epilepsy, autoimmune, pulmonary or cardiac disorders.
11. Subject has poorly controlled endocrine disorders such as diabetes.
12. Subject has an impaired immune system due to immunosuppressive diseases such as HIV or AIDS, or use of immunosuppressive medications.
13. Subject has history of collagen disorders, keloid formation or abnormal wound healing.
14. Subject takes or has taken medications, herbal preparations, food supplements or vitamins that might cause fragile skin or impaired skin healing
15. Subject has used oral steroids in past 6 months
16. Subject has used topical steroids in past 3 months
17. Subject has history of bleeding coagulopathies or use of anticoagulants.
18. Use of non-steroidal anti-inflammatory drugs (NSAIDS, e.g. ibuprofen containing agents) one week before and after each treatment session prior to treatment
19. Subject has mental disorders that in the opinion of the Investigator would be interfere with ability to comply with the study requirements.
20. Subject has any other medical condition that in the opinion of the Investigator warrants exclusion from this study
Minimum Eligible Age

25 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Lumenis Be Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Dermatology, Laser, and Vein Specialists of the Carolinas, PLLC

Charlotte, North Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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LUM-ABU-DMA-20-01

Identifier Type: -

Identifier Source: org_study_id

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